“…It is noteworthy that among all miRNAs characterized in the fourteen studies described in Table 2, only six miRNAs were identified in more than one study. In the context of VTE, miR-532 [44,55], miR-320a [51,54], miR-320b [51,54], and miR-424-5p [45,54] were found to be upregulated, miR-103a-3p [52,54,55] was downregulated, and miR-27b yielded conflicting results, as it was up-and downregulated [50,55]. Several factors may account for the poor reproducibility among studies such as differences in clinical characteristics of participants, time from the occurrence of the thrombotic event to blood sampling, conditions of sample collection, sample processing (e.g., centrifugation speed and time) and storage, protocol used for RNA isolation, and methods for miRNA quantification and data normalization [20,58].…”