Association of red blood cell distribution width, inflammation markers and morphological as well as rheological erythrocyte parameters with target organ damage in hypertension

Fornal, Maria; Wizner, Barbara; Cwynar, Marcin; Królczyk, Jarosław; Kwater, Aleksander; Korbut, R; Grodzicki, Tomasz

doi:10.3233/ch-131745

Cited by 42 publications

(36 citation statements)

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“…Besides invasive hemodynamic monitoring, altered erythrocyte parameters can be measured as surrogate markers for target organ damage in hypertension. In line with clinical observations [ 28 , 29 ], we found higher red blood cell counts and an increased RDW in SHR, corroborating the assumption that similar biophysical conditions determine microvascular damage in SHR and hypertensive patients.…”

Section: Discussionsupporting

confidence: 91%

Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel disease

Kaiser

Weise

Möller

et al. 2014

acta neuropathol commun

149

130

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IntroductionCerebral small vessel disease (cSVD) is one of the most prevalent neurological disorders. The progressive remodeling of brain microvessels due to arterial hypertension or other vascular risk factors causes subtle, but constant cognitive decline through to manifest dementia and substantially increases the risk for stroke. Preliminary evidence suggests the contribution of the immune system to disease initiation and progression, but a more detailed understanding is impaired by the unavailability of appropriate animal models. Here, we introduce the spontaneously hypertensive rat (SHR) as a model for early onset cSVD and unveiled substantial immune changes in conjunction with brain abnormalities that resemble clinical findings.ResultsIn contrast to age-matched normotensive Wistar Kyoto (WKY) rats, male SHR exhibited non-spatial memory deficits. Magnetic resonance imaging showed brain atrophy and a reduction of white matter volumes in SHR. Histological analyses confirmed white matter demyelination and unveiled a circumscribed blood brain barrier dysfunction in conjunction with micro- and macrogliosis in deep cortical regions. Flow cytometry and histological analyses further revealed substantial disparities in cerebral CD45high leukocyte counts and distribution patterns between SHR and WKY. SHR showed lower counts of T cells in the choroid plexus and meningeal spaces as well as decreased interleukin-10 levels in the cerebrospinal fluid. On the other hand, both T and NK cells were significantly augmented in the SHR brain microvasculature.ConclusionsOur results indicate that SHR share behavioral and neuropathological characteristics with human cSVD patients and further undergird the relevance of immune responses for the initiation and progression of cSVD.Electronic supplementary materialThe online version of this article (doi:10.1186/s40478-014-0169-8) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 91%

Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel disease

Kaiser

Weise

Möller

et al. 2014

acta neuropathol commun

149

130

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“…We observed that there were no significant differences between the platelet count of hypertensive subjects and controls. Our finding agrees with findings in a previous study [47]. During hypertension, there is endothelial dysfunction and this leads to platelet activation and clot formation.…”

Section: Discussionsupporting

confidence: 93%

Some Full Blood Count Parameters among Hypertensive Patients Attending Specialist Hospital, Sokoto, Nigeria

Erhabor¹,

Shehu²,

Erhabor³

et al. 2019

OJBD

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Hypertension (HTN) is a major health problem worldwide. It can lead to cardiovascular disease and functional disturbances including haematological parameters. Full blood count (FBC) parameters of a total of 60 consecutively-recruited hypertensive subjects and 30 age-matched non-hypertensive controls were studied between June and September, 2018. Ethylene Diamine Tetra Acetic Acid (EDTA) anticoagulated blood and serum from subjects and control participants were analyzed for FBC. The total white cell count (WBC), packed cell volume (PCV) haemoglobin (Hb), neutrophils and eosinophils were significantly lower among hypertensive subjects compared to non-hypertensive controls (p < 0.01, p = 0.02, p < 0.01, p < 0.01, p < 0.01) respectively. The red cell count, monocyte and lymphocyte count were significantly higher among the hypertensive subjects compared to controls (p = 0.00). There was a statistically significant variation in the haemoglobin, platelet count and red cell distribution width among the hypertensive subjects based on the stage of the hypertensive disease (p < 0.01, p = 0.01 and p < 0.01) respectively. The haematological parameters were compared among the hypertensive subjects based on age, gender and ethnicity. The PCV and platelet count were significantly higher among hypertensives >40-year-old compared to those <40 years of age (p = 0.02 and 0.01) respectively. The RBC count was significantly higher among female compared to male hypertensives (p = 0.05). The haemoglobin and monocyte count were significantly higher among male compared to female hypertensives (p = 0.02 and 0.04) respectively. The monocyte count was significantly higher among hypertensive subjects of Hausa ethnic group compared to Fulani (t = 2.79, p < 0.

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“…Inflammation induces ineffective erythropoiesis and enables immature RBCs to enter the circulation, which leads to anisocytosis [ 16 ]. It is well-established that RDW is positively correlated with various inflammatory markers [ 23 ]. Enhanced inflammation is strongly associated with the presence or severity of leukoaraiosis, and those with inflammation are at increased risk for further progression of leukoaraiosis in the follow-up studies [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

Red Blood Cell Distribution Width Is Associated with Severity of Leukoaraiosis

Lee

Kim

et al. 2016

PLoS ONE

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Red blood cell distribution width (RDW) is one of the routine hematologic parameters reported in the complete blood count test, which has been recognized as strong prognostic marker for various medical conditions, especially cardiovascular disease. We evaluated that RDW was also associated with the leukoaraiosis; common radiological finding of brain and that has been strongly associated with risk of stroke and dementia. In the present study, we included 1006 non-stroke individuals who underwent brain MRI and routine complete blood count test including RDW. Fazekas scale was used to measure the severity of leukoaraiosis based on fluid-attenuated inversion recovery image, and the severity was dichotomized to mild-degree (Fazekas scale: 0–1) and severe-degree leukoaraiosis (Fazekas scale: 2–3). Univariate and multivariate logistic regression models were constructed to evaluate independent risk factor for severe-degree of leukoaraiosis. Mean age of 1006 subjects was 64.34 ± 9.11 year, and mean of RDW was 12.97 ± 0.86%. The severe-degree of leukoaraiosis (Fazekas scale ≥ 2) was found in 28.83%. In the multivariate logistic regression, 4th quartile of RDW (> 13.3%) were significantly associated with the presence of severe-degree of leukoaraiosis (adjusted odds ratio, 1.87; 95% confidence interval, 1.20–2.92) compared to the 1st quartile of RDW (< 12.5%). The significance was not changed after adjustments for hemoglobin and other hematologic indices. These findings suggest that RDW is independently associated with severity of leukoaraiosis.

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Association of red blood cell distribution width, inflammation markers and morphological as well as rheological erythrocyte parameters with target organ damage in hypertension

Cited by 42 publications

References 0 publications

Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel disease

Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel disease

Some Full Blood Count Parameters among Hypertensive Patients Attending Specialist Hospital, Sokoto, Nigeria

Red Blood Cell Distribution Width Is Associated with Severity of Leukoaraiosis

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