Association of Red Cell Distribution Width-to-Platelet Ratio and Mortality in Patients with Sepsis

Liu, Jie; Huang, Xueying; Yue, Suru; Wang, Jia; Ye, Enlin; Huang, Jiasheng; Zhao, Yumei; Niu, Dongdong; Hou, Xuefei; Zhou, Haihong

doi:10.1155/2022/4915887

Cited by 12 publications

(6 citation statements)

References 35 publications

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“…5 (9), a017863. doi:10.1101/cshperspect.a017863 Shang, W. J., Jing, W. Z., Wang, Y. P., Kang, L. Y., Du, M., Liu, J., et al (2022). Epidemic situation of multidrug-resistant tuberculosis and change trend in Belt and Road countries.…”

Section: Discussionmentioning

confidence: 99%

Application of Data Mining in Pharmaceutical Research

Pan,

Zhao,

Jia

et al. 2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Discussionmentioning

confidence: 99%

Application of Data Mining in Pharmaceutical Research

Pan,

Zhao,

Jia

et al. 2024

Frontiers Research Topics

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“…Low ALB concentration is correlated with the higher risk of mortality in patients with diabetic ketoacidosis [ 35 ]. Existing evidence has shown the more accuracy of combined inflammation-related indexes to predict the mortality [ 36 , 37 ]. Previous studies have shown that RAR was positively associated with the all-cause mortality of patients with diabetic complications [ 7 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Association between red blood cell distribution width/albumin ratio and all-cause mortality or cardiovascular diseases mortality in patients with diabetic retinopathy: A cohort study

Fu,

Hu,

2023

PLoS ONE

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Background Red blood cell distribution width/albumin ratio (RAR) has been reported as an independent risk factor for diabetic retinopathy (DR), while its association and predictive value in the prognosis of DR patients has not been reported. This study aims to explore the association and predictive value of RAR in the prognosis of DR patients. Methods This was a retrospective cohort study based on the National Health and Nutrition Examination Survey (NHANES). The independent variable was RAR, and dependent variables were all-cause mortality and cardiovascular diseases (CVD) mortality. The association between RAR and the risk of all-cause mortality and CVD mortality was assessed using univariate and multivariate cox regression models. The results were shown as HR (hazard ratio) with 95% confidence intervals (CIs). Subgroup analysis based on age or hyperlipidemia was performed. The discrimination of the prediction model was assessed using concordance index (C-index). Results A total of 725 eligible patients were finally included in this study. The increase of RAR was associated with increased risk of all-cause mortality (HR: 1.15, 95%CI: 1.01–1.31) and CVD mortality (HR: 1.35, 95%CI: 1.12–1.63) after adjusting the covariates. We also found the significant association between higher RAR and higher risk of CVD mortality in DR patients with age < 65 years (HR: 1.35, 95%CI: 1.09–1.67) and with hyperlipidemia (HR: 1.34, 95%CI: 1.10–1.64). C-index of RAR for all-cause mortality and CVD mortality was 0.63 (95%CI: 0.59–0.67) and 0.65 (95%CI: 0.59–0.71), respectively. Conclusions Higher RAR was associated with the higher risk of all-cause mortality and CVD mortality in DR patients, and RAR may be a useful predictor for the prognosis of DR patients.

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“…The Kaplan-Meier (KM) method was applied to draw survival curves for in-hospital mortality and a log-rank test was conducted to determine the difference between the two groups. Cox proportional hazard models with hazard ratios (HRs) and 95% confidence intervals (CIs) were used to assess the effect of thiamine use on prognosis by adjusting various confounders, including demographic features, comorbidities, scoring systems, vital signs, laboratory tests, and clinical therapy ( Liu et al, 2022 ). Potential multicollinearity among variables was tested using the variance inflation factor (VIF), with a VIF ≥5, indicating the presence of multicollinearity.…”

Section: Methodsmentioning

confidence: 99%

Association of thiamine administration and prognosis in critically ill patients with heart failure

et al. 2023

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Background: Thiamine deficiency is common in patients with heart failure, and thiamine supplement can benefit these patients. However, the association between thiamine administration and prognosis among critically ill patients with heart failure remains unclear. Thus, this study aims to prove the survival benefit of thiamine use in critically ill patients with heart failure.Methods: A retrospective cohort analysis was performed on the basis of the Medical Information Mart of Intensive Care-Ⅳ database. Critically ill patients with heart failure were divided into the thiamine and non-thiamine groups depending on whether they had received thiamine therapy or not during hospitalization. The association between thiamine supplement and in-hospital mortality was assessed by using the Kaplan−Meier (KM) method and Cox proportional hazard models. A 1:1 nearest propensity-score matching (PSM) and propensity score-based inverse probability of treatment weighting (IPW) were also performed to ensure the robustness of the findings.Results: A total of 7,021 patients were included in this study, with 685 and 6,336 in the thiamine and non-thiamine groups, respectively. The kaplan−meier survival curves indicated that the thiamine group had a lower in-hospital mortality than the none-thiamine group. After adjusting for various confounders, the Cox regression models showed significant beneficial effects of thiamine administration on in-hospital mortality among critically ill patients with heart failure with a hazard ratio of 0.78 (95% confidence interval: 0.67–0.89) in the fully adjusted model. propensity-score matching and probability of treatment weighting analyses also achieved consistent results.Conclusion: Thiamine supplement is associated with a decreased risk of in-hospital mortality in critically ill patients with heart failure who are admitted to the ICU. Further multicenter and well-designed randomized controlled trials with large sample sizes are necessary to validate this finding.

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Association of Red Cell Distribution Width-to-Platelet Ratio and Mortality in Patients with Sepsis

Cited by 12 publications

References 35 publications

Application of Data Mining in Pharmaceutical Research

Application of Data Mining in Pharmaceutical Research

Association between red blood cell distribution width/albumin ratio and all-cause mortality or cardiovascular diseases mortality in patients with diabetic retinopathy: A cohort study

Association of thiamine administration and prognosis in critically ill patients with heart failure

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