Association of red cell distribution width with clinical outcomes in myelodysplastic syndrome

Baba, Yuta; Saito, Bungo; Shimada, Shotaro; Sasaki, Yohei; Murai, So; Abe, Maasa; Fujiwara, Shun; Arai, Nana; Kawaguchi, Yukiko; Kabasawa, Nobuyuki; Tsukamoto, Hiroyuki; Uto, Yui; Ariizumi, Hirotsugu; Yanagisawa, Kouji; Hattori, Norimichi; Harada, Hiroshi; Nakamaki, Tsuyoshi

doi:10.1016/j.leukres.2018.02.004

Cited by 21 publications

(22 citation statements)

References 16 publications

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“…In addition, haemoglobin disorders [35] , myelodysplastic syndromes [36] and red blood cell (RBC) transfusion increased RDW values [37] ; however, we are aware no patients in our series suffered of those disorders or received RBC transfusion before RDW determination.…”

Section: Discussionmentioning

confidence: 91%

Association between red blood cell distribution width and mortality of COVID-19 patients

Lorente

Martı́n

Argüeso

et al. 2021

Anaesthesia Critical Care & Pain Medicine

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Section: Discussionmentioning

confidence: 91%

Association between red blood cell distribution width and mortality of COVID-19 patients

Lorente

Martı́n

Argüeso

et al. 2021

Anaesthesia Critical Care & Pain Medicine

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“…RDW, in combination with MPV, may also be interpreted as monitors of bone marrow health. This is demonstrated by increased RDW with age as well as increased rates of hematologic malignancies with higher MPV and RDW which are considered negative independent prognostic factors of survival in myelofibrosis and myelodysplasia [45,51]. In fact Sousa et al, advocated RDW as a novel marker of stress erythropoiesis, which may be induced by systemic inflammatory conditions such as psoriasis [52].…”

Section: Discussionmentioning

confidence: 99%

Psoriasis and Psoriatic Arthritis Cardiovascular Disease Endotypes Identified by Red Blood Cell Distribution Width and Mean Platelet Volume

Conic

Damiani

Schrom

et al. 2020

JCM

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In a subset of psoriasis (PsO) and psoriatic arthritis (PsA) patients, the skin and/or joint lesions appear to generate biologically significant systemic inflammation. Red cell distribution width (RDW) and mean platelet volume (MPV) are readily available clinical tests that reflect responses of the bone marrow and/or plasma thrombogenicity (e.g., inflammation), and can be markers for major adverse cardiac events (MACE). We aimed to evaluate if RDW and MPV may be employed as inexpensive, routinely obtained biomarkers in predicting myocardial infarction (MI), atrial fibrillation (AF), and chronic heart failure (CHF) in psoriatic and psoriatic arthritis patients. The study was divided into two parts: (a) case control study employing big data (Explorys) to assess MPV and RDW in psoriasis, psoriatic arthritis and control cohorts; (b) a clinical observational study to validate the predictive value of RDW and to evaluate RDW response to anti-psoriatic therapies. We used Explorys, an aggregate electronic database, to identify psoriatic patients with available MPV and RDW data and compared them to gender and age matched controls. The incidence of myocardial infarction (MI), atrial fibrillation (AF), and chronic heart failure (CHF) was highest among patients with both elevated RDW and MPV, followed by patients with high RDW and normal MPV. RDW elevation among PsA patients was associated with an increased risk of MI, AF, and CHF. In a local clinical cohort, high RDWs were concentrated in a subset of patients who also had elevated circulating resistin levels. Among a small subset of participants who were treated with various systemic and biologic therapies, and observed over a year, and in whom RDW was elevated at baseline, a sustained response to therapy was associated with a decrease in RDW. RDW and MPV, tests commonly contained within routine complete blood count (CBC), may be a cost-effective manner to identify PsO and PsA patients at increased risk of MACE.

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“…Nevertheless, regression analysis revealed an almost significant correlation coefficient for RET%; thus, it was decided to be included in the final SS with a significant point‐system value. Regarding RDW‐CV%, it has been suggested that increased RDW in MDS might reflect dyserythropoiesis, associated with deregulated hemoglobin synthesis and iron metabolism . Besides that, RDW (in peripheral blood) has been also proposed as an independent predictor of an MDS diagnosis .…”

Section: Discussionmentioning

confidence: 99%

“…Regarding RDW-CV%, it has been suggested that increased RDW in MDS might reflect dyserythropoiesis, associated with deregulated hemoglobin synthesis and iron metabolism. 22 Besides that, RDW (in peripheral blood) has been also proposed as an independent predictor of an MDS diagnosis. 23 The significant value of RDW-CV% as a discriminant hematological parameter was confirmed in our data.…”

Section: Discussionmentioning

confidence: 99%

“Bone marrow aspirate automated counts on hematology analyzers: formulating a scoring system based on hematology parameters, to discriminate reactive versus myelodysplastic syndrome‐related bone marrows”

Tsagarakis¹,

Paterakis²,

Papadhimitriou³

et al. 2019

Int J Lab Hematology

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Introduction Diagnosis of myelodysplastic syndromes (MDS) is usually challenging. In this context, we have attempted to employ data derived from automated analysis of bone marrow (BM) samples as an ancillary tool for the discrimination between reactive marrow and MDS. Methods A total of 101 BM anticoagulated samples referred for flow cytometry (FCM) analysis on the clinical suspicion of MDS had been previously counted in a Mindray BC‐6800 hematology analyzer (testing set). Among them, 22/101 randomly selected BM samples (comparison set) had been also simultaneously counted by an Advia 2120 and a CELL‐DYN Sapphire hematology analyzer. Selected parameters obtained by Mindray BC‐6800 were retrospectively evaluated with ROC and regression analysis in an attempt to formulate a discriminative scoring system (SS) for MDS. This system was further evaluated in the comparison set. Results The diagnosis of MDS was established in 37/101 patients assessed (“MDS” group). Three patients were diagnosed with myelodysplastic/myeloproliferative neoplasm (MDS/MPN), while 61 revealed a “reactive” bone marrow (“RBM” group). Statistical analysis revealed significant differences in Hb, RDW‐CV%, NRBC%, and RET% values between the “MDS” and the “RBM” group. Specific cutoff values were then indicated and employed for the formulation of a SS of high sensitivity (86.84%) and specificity (86.89%). The encouraging performance characteristics of the proposed SS were also confirmed in the BM comparison set. Conclusion Automated BM counts on hematology analyzers contributed to the formulation of a SS for the screening discrimination between reactive and MDS BM fluids, which seems to be applicable and informative, regardless of the analyzer used.

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Association of red cell distribution width with clinical outcomes in myelodysplastic syndrome

Cited by 21 publications

References 16 publications

Association between red blood cell distribution width and mortality of COVID-19 patients

Association between red blood cell distribution width and mortality of COVID-19 patients

Psoriasis and Psoriatic Arthritis Cardiovascular Disease Endotypes Identified by Red Blood Cell Distribution Width and Mean Platelet Volume

“Bone marrow aspirate automated counts on hematology analyzers: formulating a scoring system based on hematology parameters, to discriminate reactive versus myelodysplastic syndrome‐related bone marrows”

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