Association of Reduced Zinc Status With Angiographically Severe Coronary Atherosclerosis: A Pilot Study

Giannoglou, George D.; Konstantinou, Dimitrios; Kovatsi, Leda; Chatzizisis, Yiannis S.; Mikhailidis, Dimitri P.

doi:10.1177/0003319710366702

Cited by 29 publications

(14 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with AMI showed significant decrease in serum zinc level than patients with UA and those who received reperfusion therapy (p= 0.033 and 0.002, respectively). These results were in agreement with the study of Giannoglou et al 2010 andCebi et al 2011 showed that serum Zn was not significantly associated with CHD risk and severity (P = 0.320). [45][46] In contrast, a study of Islamoglu et al 2011 found that serum Zn was significantly lower in patients than in healthy control (P < 0.010).…”

Section: Discussionsupporting

confidence: 92%

“…These results were in agreement with the study of Giannoglou et al 2010 andCebi et al 2011 showed that serum Zn was not significantly associated with CHD risk and severity (P = 0.320). [45][46] In contrast, a study of Islamoglu et al 2011 found that serum Zn was significantly lower in patients than in healthy control (P < 0.010). 47 Moreover, in the study of Bayir et al 2013, serum Zn concentration was significantly less in the CHD group compared to the control group (p< 0.010).…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Linkage of Some Trace Elements and Cardiac Markers in Assessment of Acute Coronary Syndromes

El-Adawy¹,

Mohamad²,

Rizk³

et al. 2018

JCDR

View full text Add to dashboard Cite

Background: Acute coronary syndrome (ACS) is accounting for any condition causing sudden reduced blood flow to the heart. Some trace elements play role in the development of ACS. Aim: This study aimed to evaluate the linkage between serum zinc, copper, iron level and cardiac markers in acute coronary syndromes. Methods: Eighty patients were divided into four groups. Group I (patients with unstable angina), Group II (acute myocardial infarction early 6 h), group III (acute myocardial infarction late 6 h) and group IV (patients with reperfusion therapy). Fifteen apparently healthy individuals served as a control group. Different risk factors as age, sex, diabetes and dyslipideamia were addressed in different groups. The correlation between Fe, Zn and Cu versus cardiac enzymes were demonstrated. The receiver operating characteristic (ROC) analysis was conducted. Results: Male and diabetic patients were significantly higher. The CK and Tn were significantly increased in groups I, II and III. The CK-MB levels were significantly increased in group II and group III. The AST levels were significantly increased in group III. The serum iron level was significantly lower in group I, II and III. Serum zinc show slight decrease in groups II and III. No significant correlation was obtained concerning serum Cu. In group II, there were significant positive correlation between Fe versus Tn, CK-MB and CK. The (ROC) analysis was identified the optimal Fe, Zn and Cu plasma level for potential prediction of development of ACS. Conclusion: Fe and Zn values were lower in ACS patients. Cu values did not show difference.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Linkage of Some Trace Elements and Cardiac Markers in Assessment of Acute Coronary Syndromes

El-Adawy¹,

Mohamad²,

Rizk³

et al. 2018

JCDR

View full text Add to dashboard Cite

show abstract

“…Such lack of association between zinc intake/plasma concentration and cardiovascular disease was similarly reported in younger adults [17] , [18] and in the prospective Physicians' Health Study II [19] . In this latter study, the same incidence of cardiovascular events was found in individuals aged 50 years or older that were randomized to nutritional supplementation with the daily-recommended dose of zinc (11 mg/day) or placebo during 11.2 years.…”

Section: Discussionsupporting

confidence: 58%

Low zinc levels is associated with increased inflammatory activity but not with atherosclerosis, arteriosclerosis or endothelial dysfunction among the very elderly

et al. 2014

View full text Add to dashboard Cite

BackgroundReduced zinc intake has been related to atherogenesis and arteriosclerosis. We verified this assumption in very old individuals, which are particularly prone to both zinc deficiency and structural and functional changes in the arterial wall.MethodsSubjects (n = 201, 80–102 years) with uneventful cardiovascular history and who were not in use of anti-inflammatory treatments in the last 30-days were enrolled. Daily intake of zinc, lipid profile, plasma C-reactive protein (CRP), plasma zinc, flow-mediated dilation (FMD), carotid ultrasonography and cardiac computed tomography were obtained. Young's Elastic Modulus, Stiffness Index and Artery Compliance were calculated.ResultsThere was no significant difference in clinical or laboratorial data between subjects grouped according to plasma zinc tertile, except for CRP (p = 0.01) and blood leukocytes (p = 0.002), of which levels were higher in the upper tertiles. The average daily intake of zinc was not significantly correlated with zinc or CRP plasma levels.The plasma zinc/zinc intake ratio was inversely correlated with plasma CRP levels (− 0.18; p = 0.01). There was no significant difference between the plasma zinc tertiles and FMD, carotid intima–media thickness, coronary calcium score, carotid plaque presence, remodeled noncalcified coronary plaques, or low-attenuation noncalcified coronary plaques.ConclusionAlthough plasma zinc level is inversely related to systemic inflammatory activity, its plasma levels of daily intake are not associated to alterations in structure or function of the arterial wall.General significanceIn the very elderly plasma concentrations or daily intake of zinc is not related to endothelial dysfunction, arteriosclerosis or atherosclerotic burden at coronary or carotid arteries.

show abstract

“…Low serum zinc/24-hour urine zinc ratio is associated with angiographically severe atherosclerosis. It was observed that low zinc levels were associated with patients with cardiovascular diseases (1,6).…”

Section: Discussionmentioning

confidence: 99%

Iron concentrations in atherosclerotic plaque and serum in patients with carotid atherosclerosis

Tasić¹,

Tasić²,

Veselinović³

et al. 2015

Acta Physiologica Hungarica

View full text Add to dashboard Cite

The aim of this study was to investigate the iron concentrations in serum and carotid plaque in patients with different morphology of carotid atherosclerotic plaque and compared with other metal ions. Carotid endarterectomy due to the significant atherosclerotic stenosis was performed in 91 patients. Control group consisted of 27 patients, without carotid atherosclerosis. Atherosclerotic plaques were divided into four morphological groups, according to ultrasonic and intraoperative characteristics. Iron, copper and zinc concentration in plaque, carotid artery and serum were measured by spectrophotometry. Serum iron concentrations were higher in patients with hemorrhagic plaques in comparison to the control group (4.7 μmol/l ± 1.2 vs. 2.1 μmol/l ± 0.8, p < 0.05). Iron concentrations were higher in patients with hemorrhagic plaques in comparison to fibrolipid plaques (72.1 ± 14.3 μg/g vs. 39.3 ± 22.9 μg/g; p < 0.05). Negative significant correlation was found for zinc in serum and plaque iron concentration in patients (p < 0.05). We also demonstrated positive significant correlation for copper and iron in serum (p < 0.05). The data obtained in the current study are consistent with the hypothesis that high iron levels may contribute to atherosclerosis and its complications as factors in a multifactorial disease.Keywords: carotid plaque, atherosclerosis, iron, zinc, copperOver the last 30 years, several studies in animals and humans assessed the effect of increased body iron levels on atherosclerosis, yielding conflicting results.Iron is a key element in many biochemical processes and shortage of iron causes damage to cells and organs. On the other hand, excess iron could be harmful because it is able to catalyse the formation of highly reactive oxygen and hydrogen radicals when present in the unbound state. Transition metal ions, established catalysts of protein, lipid and DNA oxidation, are present at elevated levels in human atherosclerotic plaques, and in some animal models, consistent with the hypothesis that metal ions contribute to both plaque formation and its destabilization (19,21,23), though the role of metal ions remains controversial (16,29).Epidemiological studies have reported an increased incidence of cardiovascular disease (CVD) in subjects with overt iron overload (7,8,19). Recent studies on cardiovascular evaluation and outcome in high-versus low-frequency blood donors have demonstrated improvements in surrogate markers of vascular health such as decreased oxidative stress, and

show abstract

Association of Reduced Zinc Status With Angiographically Severe Coronary Atherosclerosis: A Pilot Study

Cited by 29 publications

References 42 publications

Linkage of Some Trace Elements and Cardiac Markers in Assessment of Acute Coronary Syndromes

Linkage of Some Trace Elements and Cardiac Markers in Assessment of Acute Coronary Syndromes

Low zinc levels is associated with increased inflammatory activity but not with atherosclerosis, arteriosclerosis or endothelial dysfunction among the very elderly

Iron concentrations in atherosclerotic plaque and serum in patients with carotid atherosclerosis

Contact Info

Product

Resources

About