Association of regional white matter hyperintensities with hypertension and cognition in the population‐based <scp>1000BRAINS</scp> study

Gronewold, Janine; Jokisch, Martha; Schramm, Sara; Himpfen, Heiko; Ginster, Theresa; Tenhagen, Isabell; Doeppner, Thorsten R.; Jockwitz, Christiane; Miller, Tatiana; Lehmann, Nils; Moebus, Susanne; Jöckel, Karl‐Heinz; Erbel, Raimund; Caspers, Svenja; Hermann, Dirk M.

doi:10.1111/ene.15716

Cited by 9 publications

(7 citation statements)

References 23 publications

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“…Given the documented occurrence of parietal leukoaraiosis in hypertension, 59 our neural findings, which indicate reduced recruitment of the inferior parietal region in both hypertension groups are not surprising and likely reflect parietal dysfunction. Moreover, our parietal neurobehavioral finding strengthens the link between weaker neural responses and poor performance on the task.…”

Section: Discussionsupporting

confidence: 51%

Hypertension Impacts the Oscillatory Dynamics Serving the Encoding Phase of Verbal Working Memory

Arif,

Killanin,

Zhu

et al. 2024

Hypertension

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BACKGROUND: Chronic hypertension is known to be a major contributor to cognitive decline, with executive function and working memory being among the domains most commonly affected. Despite the growing literature on such dysfunction in patients with hypertension, the underlying neural processes are poorly understood. METHODS: In this cross-sectional study, we examine these neural processes by having participants with controlled hypertension, uncontrolled hypertension, and healthy controls perform a verbal working memory task during magnetoencephalography. Neural oscillations associated with the encoding and maintenance components of the working memory task were imaged and statistically evaluated among the 3 groups. RESULTS: Differences related to hypertension emerged during the encoding phase, where the hypertension groups exhibited weaker α-β oscillatory responses compared with controls in the left parietal cortices, whereas such oscillatory activity differed between the 2 hypertension groups in the right prefrontal regions. Importantly, these neural responses in the prefrontal and parietal cortices during encoding were also significantly associated with behavioral performance across all participants. CONCLUSIONS: Overall, our data suggest that hypertension is associated with neurophysiological abnormalities during working memory encoding, whereas the neural processes serving maintenance seem to be preserved. The right hemispheric neural responses likely reflected compensatory processing, which patients with controlled hypertension may use to achieve verbal working memory function at the level of controls, as opposed to the uncontrolled hypertension group where diminished resources may have limited such additional recruitment.

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Section: Discussionsupporting

confidence: 51%

Hypertension Impacts the Oscillatory Dynamics Serving the Encoding Phase of Verbal Working Memory

Arif,

Killanin,

Zhu

et al. 2024

Hypertension

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“…WMH observed in anterior regions of the brain (frontal and parietal lobes) have been associated with vascular factors in recent epidemiological studies. 22 – 25 Accordingly, the frequency of hypertension, a main predictor of WMH, was significantly different between frontal and parietal WMH terciles in our population. However, while our hypothesis was on the vascular effects of air pollution, we found no significant associations between air pollution exposure and WMH in these two lobes, except for an isolated but significant negative association between

exposure and frontal WMH volume.…”

Section: Discussionmentioning

confidence: 61%

“…Recent epidemiological studies suggest that anterior regions of the brain might be more susceptible to vascular damage. 22 – 25 In the ALFA study, frontal and parietal WMH were more consistently associated with hypertension than temporal or occipital WMH, even after taking age into account. 22 In the Northern Manhattan Study (NOMAS), participants with low levels of diastolic blood pressure (

) had decreased WMH volume in the frontal and parietal lobes compared to participants with high diastolic blood pressure (

).…”

Section: Introductionmentioning

confidence: 98%

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Ambient Air Pollution Exposure and Cerebral White Matter Hyperintensities in Older Adults: A Cross-Sectional Analysis in the Three-City Montpellier Study

Duchesne,

Carrière,

Artero

et al. 2023

Environ Health Perspect

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Background: Growing epidemiological evidence suggests an adverse relationship between exposure to air pollutants and cognitive health, and this could be related to the effect of air pollution on vascular health. Objective: We aim to evaluate the association between air pollution exposure and a magnetic resonance imaging (MRI) marker of cerebral vascular burden, white matter hyperintensities (WMH). Methods: This cross-sectional analysis used data from the French Three-City Montpellier study. Randomly selected participants 65–80 years of age underwent an MRI examination to estimate their total and regional cerebral WMH volumes. Exposure to fine particulate matter ( ), nitrogen dioxide ( ), and black carbon (BC) at the participants’ residential address during the 5 years before the MRI examination was estimated with land use regression models. Multinomial and binomial logistic regression assessed the associations between exposure to each of the three pollutants and categories of total and lobar WMH volumes. Results: Participants’ ( ) median age at MRI was 70.7 years [interquartile range (IQR): 6.1], and 52% ( ) were women. Median exposure to air pollution over the 5 years before MRI acquisition was 24.3 (IQR: 1.7) for , 48.9 (14.6) for , and 2.66 (0.60) for BC. We found no significant association between exposure to the three air pollutants and total WMH volume. We found that exposure was significantly associated with higher risk of temporal lobe WMH burden [odds ratio (OR) for an (95% confidence interval: 1.41, 2.36) for the second volume tercile, 2.04 (1.59, 2.61) for the third volume tercile, reference: first volume tercile]. Associations for other regional WMH volumes were inconsistent. Conclusion: In this population-based study in older adults, exposure was associated with increased risk of high WMH volume in the temporal lobe, strengthening the evidence on adverse effect on the brain. Further studies looking at different markers of cerebrovascular damage are still needed to document the potential vascular effects of air pollution. https://doi.org/10.1289/EHP12231

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“…disease or hypertension [2]. WMH has primarily been reported in FTD patients who carried GRN mutations without vascular factors [3].…”

mentioning

confidence: 99%

Vascular dysfunction in sporadic bvFTD: white matter hyperintensity and peripheral vascular biomarkers

Chu,

Jiang,

Nan

et al. 2024

Alz Res Therapy

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Background Vascular dysfunction was recently reported to be involved in the pathophysiological process of neurodegenerative diseases, but its role in sporadic behavioral variant frontotemporal dementia (bvFTD) remains unclear. The aim of this study was to systematically explore vascular dysfunction, including changes in white matter hyperintensities (WMHs) and peripheral vascular markers in bvFTD. Methods Thirty-two patients with bvFTD who with no vascular risk factors were enrolled in this cross-sectional study and assessed using positron emission tomography/magnetic resonance (PET/MRI) imaging, peripheral plasma vascular/inflammation markers, and neuropsychological examinations. Group differences were tested using Student’s t-tests and Mann–Whitney U tests. A partial correlation analysis was implemented to explore the association between peripheral vascular markers, neuroimaging, and clinical measures. Results WMH was mainly distributed in anterior brain regions. All peripheral vascular factors including matrix metalloproteinases-1 (MMP-1), MMP-3, osteopontin, and pentraxin-3 were increased in the bvFTD group. WMH was associated with the peripheral vascular factor pentraxin-3. The plasma level of MMP-1 was negatively correlated with the gray matter metabolism of the frontal, temporal, insula, and basal ganglia brain regions. The WMHs in the frontal and limbic lobes were associated with plasma inflammation markers, disease severity, executive function, and behavior abnormality. Peripheral vascular markers were associated with the plasma inflammation markers. Conclusions WMHs and abnormalities in peripheral vascular markers were found in patients with bvFTD. These were found to be associated with the disease-specific pattern of neurodegeneration, indicating that vascular dysfunction may be involved in the pathogenesis of bvFTD. This warrants further confirmation by postmortem autopsy. Targeting the vascular pathway might be a promising approach for potential therapy.

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Association of regional white matter hyperintensities with hypertension and cognition in the population‐based 1000BRAINS study

Cited by 9 publications

References 23 publications

Hypertension Impacts the Oscillatory Dynamics Serving the Encoding Phase of Verbal Working Memory

Hypertension Impacts the Oscillatory Dynamics Serving the Encoding Phase of Verbal Working Memory

Ambient Air Pollution Exposure and Cerebral White Matter Hyperintensities in Older Adults: A Cross-Sectional Analysis in the Three-City Montpellier Study

Vascular dysfunction in sporadic bvFTD: white matter hyperintensity and peripheral vascular biomarkers

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