Association of Relative Telomere Length and Risk of High Human Papillomavirus Load in Cervical Epithelial Cells

Albosale, Abbas Hadi; Машкина, Е. В.

doi:10.2478/bjmg-2021-0026

Cited by 2 publications

(2 citation statements)

References 35 publications

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“…Studies with telomerase-deficient mutant mice further supports the significance of telomerase in immune cell proliferation and function, as well as organ regeneration following injury [63]. Decreased telomere length has been implicated in viral infections including HIV [67], Hepatitis [62], and HPV [61].…”

Section: Telomeres and Telomerase Implication In Health And Diseasementioning

confidence: 84%

“…As such, the implication infectious diseases exert on telomere/telomerase dynamics is increasingly recognized as a critical aspect of host-pathogen interactions and disease progression [60]. Evidence from human observational studies indicates that chronic viral infections and inflammatory liver diseases correlate with telomere attrition [61,62] in specific cells potentially compromising immunocompetence and longevity. Moreover, individuals with telomerase deficiency due to rare genetic disorders exhibit heightened vulnerability to infectious diseases, and other complications [63,64].…”

Section: Telomeres and Telomerase Implication In Health And Diseasementioning

confidence: 99%

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Telomeres and Telomerase as Promising Targets for Malaria Therapy: A Comprehensive Review

Wakai,

Anzaku,

Afolabi

2024

Preprint

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Infection with the malaria parasite Plasmodium, remains a major cause of illness and death world-wide. The development of evasion strategies by the parasite from host immunity and its adaptability to antimalarial drugs has raised the urgency for developing new strategies to combat this disease. One promising avenue is targeting telomeres – sequences found at chromosome termini– and telomerase – the enzyme that catalysis synthesis of telomeres using an intrinsic RNA template. As telomeres shorten critically, cells undergo replicative senescence or apoptosis. Plasmodium, lacking telomerase activity in its human stages, exploits alternative mechanisms, accelerating telomere shortening, aging, and immune evasion. Chemical telomerase inhibitors show promise as antimalarials. In this review, we examine the potential of targeting this system in malaria therapy, with telomerase inhibitors offering a novel approach. A systematic search on PubMed using Boolean techniques identified 246 relevant articles from 1985 to March 31, 2024. After filtering, 43 articles met inclusion criteria, supplemented by snowball sampling. The telomerase inhibitor drug strategy is widely applicable against cancer. However, given the drugability of telomerase and the absolute requirement for active telomere maintenance in the vast majority of parasites including plasmodium, telomerase and telomere maintenance could well represent the Achilles heel of the parasite

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Section: Telomeres and Telomerase Implication In Health And Diseasementioning

confidence: 84%

Section: Telomeres and Telomerase Implication In Health And Diseasementioning

confidence: 99%

Telomeres and Telomerase as Promising Targets for Malaria Therapy: A Comprehensive Review

Wakai,

Anzaku,

Afolabi

2024

Preprint

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Effect of obesity and NAFLD on leukocyte telomere length and hTERT gene MNS16A VNTR variant

Kandemir,

Sahin,

Oyaci

et al. 2024

Sci Rep

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It is known that telomere length (TL) (evaluated with T/S ratio) is shortened in the presence of obesity. In this study, we aimed to investigate how obesity in adolescents and non-alcoholic liver disease (NAFLD) within the obese group affect TL and the clinical significance of the human telomerase reverse transcriptase (hTERT) gene MNS16A VNTR variant in terms of NAFLD. Adolescents with exogenous obesity and healthy controls (aged 10–19 years) who applied to our adolescent outpatient clinic between May-October 2023 were included in this study. We performed upper abdominal ultrasonography to investigate the presence of NAFLD in adolescents with obesity and divided into two groups: those without hepatosteatosis (obese NAFLD (-)) and those with hepatosteatosis (obese NAFLD (+)). We recorded body weight, height, waist circumference, and blood pressure measurements and measured the T/S ratio (telomere sequence copy number/gene single copy number) by the Quantitative Polymerase Chain Reaction method. The groups were compared using frequentist and Bayesian methods. Eighty-three obese adolescents [63 NAFLD(+) 20 NAFLD(-)] and 69 lean controls were included in the study. Pairwise comparisons revealed that T/S ratio was significantly lower in the obese NAFLD (-) group than the obese NAFLD (+) and the control group ( p = 0.025, p = 0.007, respectively). T/S ratio was lower in the LL allele group than in the other alleles ( p = 0.022) and slightly higher in the obese group with metabolic syndrome compared to the obese group without metabolic syndrome ( p = 0.072). hTERT-MNS16A-VNTR gene variant LL allele had a negative correlation with T/S ratio among the obese adolescent group. Patients with LL alleles had higher ALT, GGT, HOMA-IR, and ALT/AST. Diastolic blood pressure had a significant correlation with the T/S ratio. The T/S ratio was shorter in the obese adolescent group compared to healthy ones but was higher in the NAFLD (+) obese compared to the NAFLD (-) obese. ALT level and ALT/AST ratio were higher, T/S ratio was lower in the hTERT MNS16A VNTR variant LL allele group among obese adolescents. In addition, there was a significant correlation between the T/S ratio and diastolic blood pressure in obese adolescents.

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Association of Relative Telomere Length and Risk of High Human Papillomavirus Load in Cervical Epithelial Cells

Cited by 2 publications

References 35 publications

Telomeres and Telomerase as Promising Targets for Malaria Therapy: A Comprehensive Review

Telomeres and Telomerase as Promising Targets for Malaria Therapy: A Comprehensive Review

Effect of obesity and NAFLD on leukocyte telomere length and hTERT gene MNS16A VNTR variant

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