Association of Resistin Gene Polymorphisms with Oral Squamous Cell Carcinoma Progression and Development

Yang, Wei-Hung; Wang, Shoou-Jyi; Chang, Ya-Wen; Su, Chen-Ming; Yang, Shun‐Fa; Tang, Chih‐Hsin

doi:10.1155/2018/9531315

Cited by 18 publications

(12 citation statements)

References 36 publications

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“…Adipocyte-derived expression and secretion of resistin, a small cysteine-rich adipokine, is linked to inflammation and insulin resistance [68,74]. Some researchers have documented positive correlations between serum resistin levels and inflammatory status (erythrocyte sedimentation rate [ESR], CRP) as well as clinical disease activity (28-joint count Disease Activity Score [DAS28]) in patients with RA [22,75].…”

Section: Resistin In Arthritismentioning

confidence: 99%

“…Indeed, resistin has been found to specifically enhance the concentrations of chemokines CXCL8 and CCL2, as well as IL-6, in RA FLSs; transfecting the FLSs with adenylate cyclase-associated protein 1 (CAP1, a receptor for resistin) significantly reduced CXCL8 expression, which implicates the involvement of the resistin-CAP1 pathway in chemokine production in RA synovial tissue [67]. Plasma resistin levels also correlate with coronary artery calcification, a marker of coronary atherosclerosis [74].…”

Section: Resistin In Arthritismentioning

confidence: 99%

“…In addition, RA patients carrying the AG allele of the RETN SNP rs3219175 had higher serum CRP levels compared with controls, and had a high likelihood of being prescribed TNF inhibitors. Besides the risk for RA, genetic variation in RETN is linked to a higher likelihood of other diseases, such as MetS and colon cancer, while the RETN SNP rs186513 is implicated in a higher risk of type 2 diabetes [74]. Moreover, RETN SNPs correlated with lung cancer progression in patients with Chinese Han ethnicity [74].…”

Section: Resistin In Arthritismentioning

confidence: 99%

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Associations between Adipokines in Arthritic Disease and Implications for Obesity

MacDonald

Liu

Huang

et al. 2019

IJMS

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Secretion from adipose tissue of adipokines or adipocytokines, comprising of bioactive peptides or proteins, immune molecules and inflammatory mediators, exert critical roles in inflammatory arthritis and obesity. This review considers the evidence generated over the last decade regarding the effects of several adipokines including leptin, adiponectin, visfatin, resistin, chemerin and apelin, in cartilage and bone homeostasis in the pathogenesis of rheumatoid arthritis and osteoarthritis, which has important implications for obesity.

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Section: Resistin In Arthritismentioning

confidence: 99%

Section: Resistin In Arthritismentioning

confidence: 99%

Section: Resistin In Arthritismentioning

confidence: 99%

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Associations between Adipokines in Arthritic Disease and Implications for Obesity

MacDonald

Liu

Huang

et al. 2019

IJMS

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“…Ang2 acts as an autocrine factor in supporting endothelial cell homeostasis and counteracts Ang1 to sensitize endothelium 6. Genetic factors and single nucleotide polymorphisms (SNPs) genotyping are both pivotal to explore the risk and prognosis of tumorigenesis 7-9. SNPs in the Ang2 intron are known to be associated with breast cancer, lung injury, or acute respiratory distress syndrome 10-12.…”

Section: Introductionmentioning

confidence: 99%

Correlations between angiopoietin-2 gene polymorphisms and lung cancer progression in a Chinese Han population

Tang¹,

Chen²,

Jin³

et al. 2019

J. Cancer

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Lung cancer is the most common malignancy in China and is associated with a poor survival rate amongst Han Chinese. The high mortality is largely attributed to late-stage diagnosis, when treatment is largely ineffective. Identification of genetic variants could potentially assist with earlier diagnosis and thus more effective treatment. The development and progression of lung cancer is stimulated by angiopoietin-2 (Ang2), a ligand for Tie2, an endothelial tyrosine kinase. Patients with lung cancer with higher serum Ang2 levels have significantly poorer survival than patients with lower serum Ang2 levels. We explored the effects of Ang2 single nucleotide polymorphisms (SNPs) on lung cancer susceptibility. We used lung cancer tissue and serum samples to measure Ang2 expression in a Chinese Han population. Five Ang2 SNPs (rs2442598, rs734701, rs1823375, 11137037, and rs12674822) were analyzed using TaqMan SNP genotyping in 695 patients with lung cancer and 900 cancer-free controls. Carriers of the variant GT allele of rs12674822 had a higher risk of lung cancer than wild-type (GG) carriers, while the presence of the CC genotype at rs11137037 was associated with higher clinical stage disease compared with having the AA genotype. Our study is the first to document a correlation between Ang2 polymorphisms and lung cancer development and progression in people of Chinese Han ethnicity.

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“…A single nucleotide polymorphism (SNP) is a variation in a single nucleotide occurring at a specific site in the genome [11][12][13][14]. Comparisons of SNP distribution frequencies among patient populations (e.g., patients and controls) are commonly applied to predict disease risk and prognosis, including RA [15,16].…”

Section: Ivyspringmentioning

confidence: 99%

VEGF-C Gene Polymorphisms Increase Susceptibility to Rheumatoid Arthritis

Dai

Kuo

et al. 2019

Int. J. Med. Sci.

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Vascular endothelial growth factor C (VEGF-C) promotes angiogenesis, a prominent feature in rheumatoid synovitis, contributing to the perpetuation of the global burden of rheumatoid arthritis (RA). VEGF-C gene polymorphisms predict the risk of developing various human diseases, such as urothelial cell carcinoma, oral cancer and coronary artery disease. We sought to determine whether single nucleotide polymorphisms (SNPs) of the VEGF-C gene can predict the risk of RA. Our study recruited 210 patients with RA and 373 healthy controls between 2007 and 2015, and performed comparative genotyping for SNPs rs7664413, rs11947611, rs1485766, rs2046463 and rs3775194. In analyses adjusted for potential covariates, we found that compared with subjects with the A/A genotype of SNP rs11947611, those with the A/G genotype were 40% more likely to develop RA (adjusted odds ratio [AOR] 0.61; 95% confidence interval [CI] 0.40 to 0.92; p = 0.02). In addition, subjects lacking the A/A genotype (A/G, G/G) of SNP rs2046463 were more than twice as likely as those with the A/A genotype to require methotrexate (AOR 2.23, 95% CI 1.25 to 3.98; p = 0.01), while those who lacked the G/G genotype (G/C, C/C) in the SNP rs3775194 had a significantly lower risk of requiring prednisolone as compared with those with the G/G genotype (AOR 0.39, 95% CI 0.19 to 0.79; p = 0.01). Our findings suggest that VEGF-C gene polymorphisms might serve as a diagnostic marker and therapeutic target for RA therapy. Pharmacotherapies that modulate the activity of the VEGF-C gene may be promising for RA treatment.

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Association of Resistin Gene Polymorphisms with Oral Squamous Cell Carcinoma Progression and Development

Cited by 18 publications

References 36 publications

Associations between Adipokines in Arthritic Disease and Implications for Obesity

Associations between Adipokines in Arthritic Disease and Implications for Obesity

Correlations between angiopoietin-2 gene polymorphisms and lung cancer progression in a Chinese Han population

VEGF-C Gene Polymorphisms Increase Susceptibility to Rheumatoid Arthritis

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