Association of retinal microvascular caliber with blood pressure levels

Gepstein, Raz; Rosman, Yossi; Rechtman, Ehud; Koren‐Morag, Nira; Segev, Shlomo; Assia, Ehud I.; Grossman, Ehud

doi:10.3109/08037051.2012.645336

Cited by 23 publications

(19 citation statements)

References 22 publications

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“…The lack of association between CRAE and DR also has been reported in previous studies,6–8 In contrast to CRVE, CRAE has been inconsistently reported to be associated with DR in the previous studies. In accordance with what has been shown in other studies, a strong and consistent association between retinal arteriolar narrowing and hypertension has been found in the present study 21 22…”

Section: Discussionsupporting

confidence: 94%

Relationship of retinal vascular calibre and diabetic retinopathy in Chinese patients with type 2 diabetes mellitus: the Desheng Diabetic Eye Study

Yang

Deng

et al. 2016

Br J Ophthalmol

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Section: Discussionsupporting

confidence: 94%

Relationship of retinal vascular calibre and diabetic retinopathy in Chinese patients with type 2 diabetes mellitus: the Desheng Diabetic Eye Study

Yang

Deng

et al. 2016

Br J Ophthalmol

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“…Hypertensive retinopathy is the most common ophthalmologic manifestation of hypertension [37]. Our study results indicated that CRAE was highly correlated with MAP, consistent with numerous studies in different populations including Singaporeans [23], Japanese [38], Caucasians [2], [3], [33], [39], African-Americans [4], and multiethnic populations [5].…”

Section: Discussionsupporting

confidence: 90%

“…A number of studies [23], [24], [35], [37], [43] have shown that CRVE is not associated with hypertension. The current study also demonstrated no significant association between CRVE and hypertension, but found that a narrow CRVE was not related to an increased PP difference, which is inconsistent with the Rotterdam Study [34].…”

Section: Discussionmentioning

confidence: 99%

The Relationship of Retinal Vessel Diameters and Fractal Dimensions with Blood Pressure and Cardiovascular Risk Factors

et al. 2014

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BackgroundThis study aimed to investigate the correlation between quantitative retinal vascular parameters such as central retinal arteriolar equivalent (CRAE) and retinal vascular fractal dimension (D(f)), and cardiovascular risk factors in the Chinese Han population residing in the in islands of southeast China.Methodology/Principle FindingsIn this cross-sectional study, fundus photographs were collected and semi-automated analysis software was used to analyze retinal vessel diameters and fractal dimensions. Cardiovascular risk factors such as relevant medical history, blood pressure (BP), lipids, and blood glucose data were collected. Subjects had a mean age of 51.9±12.0 years and included 812 (37.4%) males and 1,357 (62.6%) females. Of the subjects, 726 (33.5%) were overweight, 226 (10.4%) were obese, 272 (12.5%) had diabetes, 738 (34.0%) had hypertension, and 1,156 (53.3%) had metabolic syndrome. After controlling for the effects of potential confounders, multivariate analyses found that age (β = 0.06, P = 0.008), sex (β = 1.33, P = 0.015), mean arterial blood pressure (β = −0.12, P<0.001), high-sensitivity C-reactive protein (β = −0.22, P = 0.008), and CRVE (β = 0.23, P<0.001) were significantly associated with CRAE. Age (β = −0.0012, P<0.001), BP classification (prehypertension: β = −0.0075, P = 0.014; hypertension: β = −0.0131, P = 0.002), and hypertension history (β = −0.0007, P = 0.009) were significantly associated with D(f).Conclusions/SignificanceD(f) exhibits a stronger association with BP than CRAE. Thus, D(f) may become a useful indicator of cardiovascular risk.

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“…Retinal arteriolar narrowing has long been recognized as one of the earliest sign of hypertension secondary to chronic exposure to increased blood pressure and is inversely related to higher blood pressure levels. This finding was subsequently confirmed in multiple population-based studies [12,22,23,24,25]. A recent meta-analysis of five cross-sectional studies (including 19,633 subjects) showed that arteriolar caliber decreased by 3.07 µm [95% confidence interval (CI): 2.40-3.73 µm] for every 10-mm Hg increase in arterial blood pressure [26].…”

Section: Determinants Of Retinal Vascular Calibersmentioning

confidence: 82%

“…Of the different systemic diseases, the strongest relationship has been reported between retinal vascular calibers and hypertension [12,22,23,24,25]. Retinal arteriolar narrowing has long been recognized as one of the earliest sign of hypertension secondary to chronic exposure to increased blood pressure and is inversely related to higher blood pressure levels.…”

Section: Determinants Of Retinal Vascular Calibersmentioning

confidence: 99%

Retinal Vascular Caliber Measurements: Clinical Significance, Current Knowledge and Future Perspectives

Ikram¹,

Ong

Cheung³

et al. 2012

Ophthalmologica

191

187

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The retinal vasculature provides a unique window to assess vascular health noninvasively and directly in vivo. Advances in fundus photography and retinal image analysis techniques have enabled the objective and accurate assessment of quantitative retinal vascular caliber measurement. Over the last decade, large population-based studies have shown that retinal vascular calibers are associated with a wide range of subclinical (e.g. atherosclerosis, inflammation and endothelial dysfunction) and clinical cardiovascular diseases (hypertension, diabetes mellitus, stroke, kidney and heart diseases). However, while retinal image analysis provided exciting possibilities to study the pathogenesis of these diseases, its direct applicability in a clinical setting as a ‘test' to predict cardiovascular diseases is yet to be established, particularly within the context of being used as a population screening tool. Nevertheless, with continual development of retinal imaging techniques and newer understanding of the clinical significance of these retinal changes, there remains scope for the development of retinal vascular caliber measurements as a biomarker for vascular disease risk assessment in targeted areas and patient subgroups (e.g. patients with diabetes, suspected hypertension and stroke).

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Association of retinal microvascular caliber with blood pressure levels

Abstract: The association between different cardiovascular risk factors and hypertensive retinopathy is complex. Effective blood pressure control has a beneficial effect on the vascular changes in the retina.

Cited by 23 publications

References 22 publications

Relationship of retinal vascular calibre and diabetic retinopathy in Chinese patients with type 2 diabetes mellitus: the Desheng Diabetic Eye Study

Relationship of retinal vascular calibre and diabetic retinopathy in Chinese patients with type 2 diabetes mellitus: the Desheng Diabetic Eye Study

The Relationship of Retinal Vessel Diameters and Fractal Dimensions with Blood Pressure and Cardiovascular Risk Factors

Retinal Vascular Caliber Measurements: Clinical Significance, Current Knowledge and Future Perspectives

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