Association of retinal venular tortuosity with impaired renal function in the Northern Ireland Cohort for the Longitudinal Study of Ageing

O'Neill, R A; Maxwell, Alexander P.; Kee, Frank; Hogg, Ruth; McKay, Gareth J.

doi:10.1186/s12882-020-02031-0

Cited by 12 publications

(9 citation statements)

References 54 publications

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“…NICOLA is a longitudinal cohort study of 8478 community-dwelling men and women ≥50 years of age, resident in Northern Ireland (individuals in care homes or other residential institutions were excluded at baseline) [ 34 ]. The study was established in 2013 with three main components: a computer-aided personal interview (CAPI), a self-completion questionnaire and a health assessment.…”

Section: Methodsmentioning

confidence: 99%

Association of renal impairment with cognitive dysfunction in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA)

Paterson

Maxwell

Kee

et al. 2021

Nephrology Dialysis Transplantation

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Introduction Chronic kidney disease (CKD) is a recognised risk factor for cognitive impairment. Identification of those at greatest risk of cognitive impairment may facilitate earlier therapeutic intervention. This study evaluated associations between estimated glomerular filtration rate (eGFR) and cognitive function in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA). Methods Data were available for 3,412 participants ≥ 50 years old living in non-institutionalised settings who attended a health assessment between Feb 2014 and Mar 2016. Measures of serum creatinine (cr) and cystatin-C (cys) were used for eGFR. Cognitive function was measured using the Montreal Cognitive Assessment (MoCA) and the Mini Mental State Examination (MMSE). Results Following adjustment for potential confounders, a single unit decrease in eGFR was significantly associated with reduced cognitive function defined by MMSE ≤24/30 (eGFRcys: β -0.01, 95% confidence intervals [CI]: -0.001, -0.01; p = 0.01) and MoCA <26/30 (β -0.01, 95% CI: -0.002, -0.02; p = 0.02). Similarly, CKD stages 3-5 were also associated with a moderate increase in the odds of cognitive impairment (MMSE ≤ 24) following adjustment for confounders (eGFRcys: OR 2.73, 95% CI: 1.38, 5.42, p = 0.004). Conclusions Decreased eGFRcys was associated with a significantly increased risk of cognitive impairment in a population-based cohort of older adults. However, there was no evidence of association between cognitive impairment and the more commonly used eGFRcr-based calculation. eGFRcys may offer improved sensitivity over eGFRcr in the determination of renal function and associated risk of cognitive impairment.

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Section: Methodsmentioning

confidence: 99%

Association of renal impairment with cognitive dysfunction in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA)

Paterson

Maxwell

Kee

et al. 2021

Nephrology Dialysis Transplantation

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“…NICOLA is a longitudinal cohort study of 8468 participants aged 50 years and over, living in the Northern Ireland community (individuals in care homes or other residential institutions were excluded [ 32 , 33 ];). The study was established in 2012 with three main components: a computer-aided personal interview (CAPI), a self-completion questionnaire and health assessment.…”

Section: Methodsmentioning

confidence: 99%

Retinal microvascular parameters are not significantly associated with mild cognitive impairment in the Northern Ireland Cohort for the Longitudinal Study of Ageing

O'Neill¹,

Maxwell²,

Paterson³

et al. 2021

BMC Neurol

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Background The retinal and cerebral microvasculature share similar embryological origins and physiological characteristics. Improved imaging technologies provide opportunistic non-invasive assessment of retinal microvascular parameters (RMPs) against cognitive outcomes. We evaluated baseline measures for associations between RMPs and mild cognitive impairment (MCI) from participants of the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA). Methods RMPs (central retinal arteriolar / venular equivalents, arteriole to venular ratio, fractal dimension and tortuosity) were measured from optic disc centred fundus images and analysed using semi-automated software. Associations between RMPs and MCI were assessed by multivariable logistic regression with adjustment for potential confounders including age, sex, alcohol consumption, smoking status, educational attainment, physical activity, cardiovascular disease (CVD), hypertension, mean arterial blood pressure, triglycerides, diabetes, body mass index, and high density lipoprotein levels. P < 0.05 was considered statistically significant. Results Data were available for 1431 participants, of which 156 (10.9%) were classified with MCI defined by a Montreal Cognitive Assessment (MoCA) score ≤ 26, with subjective cognitive decline, in the absence of depression or problems with activities of daily living. Participants had a mean age of 62.4 ± 8.5 yrs. and 52% were female. As expected, individuals with MCI had a lower MoCA score than those without (23.5 ± 2.6 versus 26.3 ± 2.7, respectively), were more likely to be female, have a lower level of educational attainment, be less physically active, more likely to have CVD, have higher levels of triglycerides and lower levels of high density lipoprotein. No significant associations between RMPs and MCI were detected in unadjusted, minimally adjusted or fully adjusted regression models or subsequent sensitivity analyses. Conclusion Previous studies have reported both increased retinal venular calibre and reduced fractal dimension in association with mild cognitive impairment. Our study failed to detect any associations between RMPs and those individuals at an early stage of cognitive loss in an older community-based cohort.

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“…This study collected health and lifestyle data from 8452 free-living individuals in Northern Ireland, aged 50 years and over with planned 10-year follow-up assessments for consenting participants. Baseline data were collected between December 2013 and March 2016 (NCT number: NCT01938898 [ 28 ]). The study adhered to principles outlined in the Declaration of Helsinki.…”

Section: Methodsmentioning

confidence: 99%

Dietary patterns associated with renal impairment in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA)

Paterson¹,

Neville²,

Wallace³

et al. 2021

Eur J Nutr

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Background Dietary-based primary prevention guidelines for chronic kidney disease (CKD) treatment are lacking due to limited evidence. Single nutrient intake studies do not account for complex dietary interactions. We assessed associations between dietary patterns and renal function in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA). Design A cross-sectional observational study used NICOLA baseline dietary data collected between February 2014 and March 2016 via a food frequency questionnaire for 2590 participants aged ≥ 50 years. Principal component analysis identified a posteriori dietary patterns. Renal function was characterised by estimated glomerular filtration rate (eGFR) using serum creatinine and cystatin-C. Associations were assessed according to quintiles of dietary pattern adherence and multivariable regression analysis examined associations with eGFR. Results Variation in three dietary patterns was significantly associated with eGFR. After adjustment for potential confounders, participants with least adherence to the ‘healthy’ dietary pattern 1 had a mean eGFR 3.4 ml/min/1.73m2 (95% confidence interval, [CI] − 5.0, − 1.7, p < 0.001) lower than the most adherent. Those with lowest adherence to the ‘unhealthy’ dietary pattern 2 had a mean eGFR 1.9 ml/min/1.73m2 (CI 0.2, 3.5, p = 0.03) higher than those with highest adherence. Participants with lowest adherence to dietary pattern 3, characterised by a high consumption of alcohol and coffee, had a mean eGFR 1.8 ml/min/1.73m2 (− 3.5, − 0.01, p = 0.05) lower than those with greatest adherence. Conclusions Our findings identify independent associations between dietary patterns and eGFR. These findings can inform the development of diet-related primary prevention advice for CKD.

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Association of retinal venular tortuosity with impaired renal function in the Northern Ireland Cohort for the Longitudinal Study of Ageing

Cited by 12 publications

References 54 publications

Association of renal impairment with cognitive dysfunction in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA)

Association of renal impairment with cognitive dysfunction in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA)

Retinal microvascular parameters are not significantly associated with mild cognitive impairment in the Northern Ireland Cohort for the Longitudinal Study of Ageing

Dietary patterns associated with renal impairment in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA)

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