Association of retinol binding protein 4 with risk of gestational diabetes

Abstract

Aim We investigated association of maternal retinol binding protein 4 (RBP4) with risk of gestational diabetes (GDM). Methods GDM cases (N=173) and controls (N=187) were selected from among participants of a cohort study of risk factors of pregnancy complications. Early pregnancy (16 weeks on average) serum RBP4 concentration was measured using an ELISA-based immunoassay. Logistic regression was used to estimate unadjusted and adjusted odds ratios (ORs/aORs) and 95% confidence intervals (95%CI). Results Mean serum RBP4 was significantly higher among GDM cases compared with controls (47.1 vs. 41.1 μg/ml, respectively; p-value<0.05). Participants in the highest quartile for serum RBP4 had a 1.89-fold higher risk of GDM compared with participants in the lowest quartile (95%CI: 1.05-3.43). However, this relationship did not reach statistical significance after adjustment for confounders (aOR: 1.54; 95%CI: 0.82-2.90). Women who were ≥35 years old and who had high RBP4 (≥38.3 μg/ml, the median) had a 2.31-fold higher risk of GDM compared with women who were < 35 years old and had low RBP4 (<38.3 μg/ml) (aOR: 2.31; 95%CI: 1.26-4.23; p-value for interaction=0.021). Conclusion Overall, there is modest evidence of a positive association of early pregnancy elevated RBP4 concentration with increased GDM risk, particularly among women with advanced age.

A Prospective Study of Maternal Plasma Concentrations of Retinol-Binding Protein 4 and Risk of Gestational Diabetes Mellitus

“…Similarly, Su et al [12] also reported that serum RBP4 levels are significantly increased in pregnancy. Furthermore, consistent with our findings, previous studies confirmed that patients with GDM had higher median plasma concentration of RBP4 than normal pregnant women [1,12,22,[34][35][36]. However, other studies found that there were no significant differences in serum RBP4 between the controls and those that developed GDM group [14,37,38].…”

“…Gestational diabetes mellitus (GDM), a common complication of pregnancy occurring in 5-10% of all pregnancies, is characterized by glucose intolerance that first appears during pregnancy [1]. One out of every 5 pregnant women in Beijing either had GDM and this constitutes a huge health burden for health services [2].…”

First trimester concentrations of the TTR-RBP4-retinol complex components as early markers of insulin-treated gestational diabetes mellitus

“…Conversely, the correlation between RBP4 and the Brought to you by | University of Windsor Authenticated Download Date | 10/8/15 1:11 PM pathogenesis of GDM has been already debated in the past, showing conflicting results. In some studies a positive correlation between RBP4 and GDM was shown [23,24], while in some other reports it was not [25,26]. The only study conducted in first trimester maternal serum, already previously cited, showed no statistically significant correlation between RBP4 and GDM [14].…”

Circulating retinol-binding protein 4 levels in gestational diabetes mellitus: a meta-analysis of observational studies

“…Although the association between RBP4 and metabolic dysfunction is well established, studies on the relationship between circulating RBP4 levels and the risk of GDM have yielded inconclusive results [16][17][18][19][20][21][22][23][24][25][26][27][28][29]. For instance, several studies suggested significantly enhanced serum levels of RBP4 in GDM [16,17,19,20,23,[25][26][27][28][29], while some reports showed decreased or no different RBP4 concentrations between GDM serum specimen compared with those of controls [18,21,22,24,29].…”