Association of rheumatoid arthritis treatment response and disease duration with declines in serum levels of IgM rheumatoid factor and anti–cyclic citrullinated peptide antibody

Abstract

Objective. To examine the association of treatment response and disease duration with changes in rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibody levels among patients with rheumatoid arthritis (RA).Methods. The study sample included 66 RA patients who completed double-blind, randomized clinical protocols and for whom baseline and followup serum samples were available. Anti-CCP and RF levels were measured using commercially available assay kits. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to describe the association of response and disease duration with declines in antibody levels.Results. Patients had a mean ؎ SD age of 49.9 ؎ 12.0 years and were predominantly female (n ‫؍‬ 51; 77%). The mean ؎ SD duration between the times at which the baseline and followup serum samples were obtained was 13.7 ؎ 8.6 months. Among the 64 subjects with positive antibody at baseline, 33 (52%) experienced a >25% reduction in the anti-CCP antibody level during the course of treatment, and 35 patients (55%) had a >25% reduction in RF. After adjustment for the baseline anti-CCP antibody level, only a shorter disease duration (<12 months) was significantly associated with a decline in the level of anti-CCP antibody (OR 3.0, 95% CI 1.0-8.8), and no association with treatment response was observed. Conversely, treatment response was the only significant determinant of a decrease in RF levels (OR 3.6, 95% CI 1.2-10.4).Conclusion. Shorter disease duration predicts greater declines in anti-CCP antibody levels with treatment in RA. Although treatment response is a robust determinant of a decrease in RF, it does not appear to be associated with declines in the anti-CCP antibody level.

Diagnostic Value of Antibodies against a Modified Citrullinated Vimentin in Rheumatoid Arthritis

“…In our study, we have shown that, the levels of anti-CP2 were significantly increased in the serum of the C patients with RA in comparison with the controls (p < 0.001). This results in agreement with other studies [22,23].…”

Age-related diagnostic utility of rheumatoid factor, anticyclic citrullinated peptide and antikeratin antibodies in Chinese patients with rheumatoid arthritis

“…RF levels are elevated in 75% of patients with RA and this analysis is widely used for diagnosis. 25 ACPA positivity is frequently observed in patients with RA, especially in early disease, 26,27 and has a specificity approaching 100% for RA diagnosis. 28 The sensitivities of RF, ACPA and AKA in patients aged >16 years in the present study were 80.1%, 78.2% and 29.1%, respectively, and there Data presented as n (%).…”

Vitamin D Receptor Gene Polymorphisms in Rheumatoid Arthritis

“…Anti-CCP can be a better prognostic factor as shown in various studies. [19][20] However, we have only the RF results as a part of our previous study.…”