“…In the selected studies on TL, PA was the most studied lifestyle factor, followed by smoking and sleep. In general, being physical active, not smoking and having good sleep quality are associated with a reduced risk of morbimortality for the main chronic diseases [ 8 , 9 , 10 , 11 , 144 , 145 , 146 , 147 ]. There is a challenge in searching for the best biomarker of aging and despite these limitations and the advantage of measuring a combination of biomarkers instead of only one [ 148 , 149 ], TL is the most extensively studied biomarker of age-related diseases [ 7 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ].…”