Association of rosacea with depression and anxiety: A systematic review and meta-analysis

Chang, Ho‐Myung; Huang, Yu‐Chen; Lien, Yueh-Ju; Chang, Yin-Shuo

doi:10.1016/j.jad.2021.12.008

Cited by 30 publications

(30 citation statements)

References 24 publications

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“… 11 , 28–30 Also, the burden of psychiatric comorbidity was highlighted in rosacea patients, such as anxiety, depression, Parkinson’s and Alzheimer’s disease, and dementia. 14 , 31–33 The psychosocial impact in patients with rosacea can result in severe and debilitating, but it is underestimated in clinical practice. 34 The results from a systematic review and meta-analysis which included a total of 14 studies involving 14,134,021 patients with rosacea were revealed and indicated that patients with rosacea are at a higher risk of experiencing depression and anxiety, the pooled prevalence of depression was 19.6% (95% confidence interval [CI] 15.0–24.3%) and that of anxiety was 15.6% (95% CI 11.8–19.3%).…”

Section: Discussionmentioning

confidence: 99%

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Serum Level of Brain-Derived Neurotrophic Factor (BDNF) Associated with Depression in Patients with Rosacea: A Candidate Predictive Biomarker

Wang¹,

Liu²,

Jia³

et al. 2022

CCID

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Background The biomarker to predict the depression in patients with rosacea was absent. Objective We aimed to explore the potential association between BDNF and depression in patients with rosacea, and also to determine whether serum BDNF level is a potential biomarker for identifying depression in patients with rosacea. Methods The patients with rosacea, rosacea with depression and healthy control were included, clinical evaluation (DLQI, RSSs, BDI-II) and serum BDNF levels detection were performed on subjects, the comparisons and correlation analysis of the obtained data were performed. Results In clinical evaluation, whether DLQI or RSSs, rosacea with depression group was significantly higher compared to rosacea group. Besides, we found the serum BDNF levels were lower in patients with rosacea and rosacea with depression compared to healthy controls, also in the rosacea with depression group, serum BDNF levels were lower than in rosacea patients. Whatever in rosacea or rosacea with depression group, the statistical significance of serum BDNF levels between the different subtypes like the ETR and PPR was not found. In further correlation analysis, we found no correlation between serum BDNF and RSSs in patients with rosacea whatever the subtype of ETR or PPR. Interestingly, we found a negative correlation between serum BDNF levels and BDI-II in rosacea with depression group, the decreased serum BDNF levels were associated with the increased BDI-II, also the ROC confirmed it can evaluate the depression in patients with rosacea. Conclusion Serum BDNF level is a potential biomarker for identifying depression in patients with rosacea.

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Section: Discussionmentioning

confidence: 99%

“… 12 , 13 The relationship between the rosacea and its comorbidity with psychiatric disorders remains controversial. 14 …”

Section: Introductionmentioning

confidence: 99%

Serum Level of Brain-Derived Neurotrophic Factor (BDNF) Associated with Depression in Patients with Rosacea: A Candidate Predictive Biomarker

Wang¹,

Liu²,

Jia³

et al. 2022

CCID

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“… 6 A recent systematic reviews showed that rosacea may predispose patients to develop depression and anxiety. 7 In this case, the patient’s facial redness has consulted to the dermatology department, and we invited dermatology, rehabilitation, hematology and other departments for consultation and multidisciplinary cooperation. Considering the patient’s extreme anxiety and the good treatment effect of venlafaxine, as well as the follow-up situation, we believed that facial flushing caused by anxiety, but do not rule out rosacea.…”

Section: Discussionmentioning

confidence: 99%

Facial Flushing Associated with Anxiety and Improved by Venlafaxine: A Case Report

Qiu¹,

Liu²,

Tang³

2022

CCID

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Facial flushing affects the work and life of patients. The specific pathogenesis and conditions of facial flushing may be complicated. A 47-year-old perimenopausal woman was presented to the Pain Management with a 4-month history of facial flushing. The patient didn’t have any history of special illness or history of allergies. Treatments with methylprednisolone, thalidomide, hydroxychloroquine drugs or sympathetic blockages (stellate ganglion block) were unable to effectively improve the symptoms. We believed that the facial flushing might be associated with the anxiety. After two weeks of venlafaxine medication, the symptoms were 90% relieved. We found that venlafaxine effectively improved flushing that may be related to anxiety.

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“…Badania kliniczne wskazują również na możliwość współwystępowania trądziku różowatego z objawami lęku i depresji. W piśmiennictwie opisywano także związek trądziku różowatego z chorobą Parkinsona, demencją (w szczególności z chorobą Alzheimera), stwardnieniem rozsianym oraz glejakami mózgu [70]. Współwystępowanie migreny stwierdzano częściej u kobiet z postacią oczną choroby [71].…”

Section: Rosacea and Coexisting Conditionsunclassified

“…Clinical trials also indicate a possible coexistence of rosacea with symptoms of anxiety and depression. The literature also describes a relationship between rosacea and Parkinson's disease, dementia (in particular with Alzheimer's disease), multiple sclerosis and brain gliomas [70]. Coexistence of migraine has been reported more frequently in women with the ocular form of the disease [71].…”

Section: Rosacea and Coexisting Conditionsmentioning

confidence: 99%

Rosacea. Diagnostic and therapeutic recommendations of the Polish Dermatological Society. Part 1. Epidemiology, classification and clinical presentation

Woźniacka¹,

Czuwara²,

Krasowska³

et al. 2022

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EPIDEMIOLOGyRosacea is diagnosed on the basis of morphological criteria, hence there is a view that the reported incidence of the disease is lower than the actual one, especially in the case of its mild course or in people with a high skin phototype. However, it is not a rare disease, as it affects about 5% of the world's population. There is controversy in the literature regarding the prevalence of rosacea among men and women. Some authors indicate that the incidence of the disease is similar, while others emphasize that it affects women more often. Rosacea is usually diagnosed in adults between 30 and 50 years of age. Most often the disease occurs in people with fair skin, living in the northwestern part of Europe, mainly Irish, Scots and Celts with I or II skin phototype, or their relatives. It should be emphasized, however, that in about 10% of EPIDEMIOLOGIA Trądzik różowaty rozpoznawany jest na podstawie kryteriów morfologicznych, dlatego też istnieje pogląd, że raportowana częstość występowania choroby jest niższa od rzeczywistej, zwłaszcza w przypadku jej łagodnego przebiegu lub u osób z wysokim fototypem skóry. Nie jest to jednak choroba rzadka, ponieważ dotyczy około 5% osób na świecie. W piśmiennictwie istnieją kontrowersje dotyczące częstości występowania rosacea wśród mężczyzn i kobiet. Część autorów wskazuje, że częstość występowania choroby jest podobna, inni podkreślają, że częściej dotyczy kobiet. Trądzik różowaty rozpoznawany jest zwykle u osób dorosłych, pomiędzy 30. a 50. rokiem życia. W większości występuje u ludzi z niskim fototypem, zamieszkujących północno-zachodnie krańce Europy, głównie Irlandczyków, Szkotów i Celtów

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Association of rosacea with depression and anxiety: A systematic review and meta-analysis

Cited by 30 publications

References 24 publications

Serum Level of Brain-Derived Neurotrophic Factor (BDNF) Associated with Depression in Patients with Rosacea: A Candidate Predictive Biomarker

Serum Level of Brain-Derived Neurotrophic Factor (BDNF) Associated with Depression in Patients with Rosacea: A Candidate Predictive Biomarker

Facial Flushing Associated with Anxiety and Improved by Venlafaxine: A Case Report

Rosacea. Diagnostic and therapeutic recommendations of the Polish Dermatological Society. Part 1. Epidemiology, classification and clinical presentation

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