Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia

Schwab, Sibylle G.; Kusumawardhani, Agung; Dai, Nan; Qin, WenWen; Wildenauer, Mutiara D.B.; Agiananda, Feranindhya; Amir, Nurmiati; Antoni, Ronald; Arsianti, Tiana; Asmarahadi, Asmarahadi; Diatri, Hervita; Djatmiko, Prianto; Irmansyah, Irmansyah; Khalimah, Siti; Kusumadewi, Irmia; Kusumaningrum, Profitasari; Lukman, Petrin Redayani; Mustar, Lukman; Nasrun, Martina Wiwie Setiawan; Naswati, Safyuni; Prasetiyawan, Prasetiyawan; Semen, Gerald M.; Siste, Kristiana; Tobing, Heriani; Raharjanti, Natalia Widiasih; Wiguna, Tjhin; Wulandari, Widayanti Dewi; Benyamin, Beben; Wildenauer, Dieter B.

doi:10.1016/j.schres.2013.03.022

Cited by 31 publications

(18 citation statements)

References 38 publications

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“…It should be noted that, as the sample size increased, this association between rs1344706 and BD was strengthened as indicated by sharply reduced P -value (seen in the meta-analysis), suggesting that rs1344706 may serve as an authentic risk SNP for BD in Chinese populations. Moreover, stratified analysis by gender showed that rs1344706 was associated with male BD ( P = 0.034) but not with female BD ( P = 0.218) in our samples, which was consistent with previous studies32. However, this association observed for rs1344706 with BD should be treated scrupulously, since the sample size used in the present study was underpowered which might inflate potential false positive associations and even drew an opposite conclusion.…”

Section: Discussionsupporting

confidence: 89%

Genetic association of rs1344706 in ZNF804A with bipolar disorder and schizophrenia susceptibility in Chinese populations

Rao

Yao

Ryan

et al. 2017

Sci Rep

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Rs1344706 in the the zinc finger protein 804A (ZNF804A) gene has been identified to be associated with schizophrenia and bipolar disorder (BD) in Europeans. However, whether rs1344706 is associated with schizophrenia in Chinese populations remains inconclusive; furthermore, the association between rs1344706 and BD in Chinese populations has been rarely explored. To explore the association between rs1344706 and schizophrenia/BD in Chinese populations, we genotyped rs1344706 among 1128 Chinese subjects (537 patients with BD and 591 controls) and found that rs1344706 showed marginal allelic association with BD (P = 0.028) with T-allele being more prevalent in cases than that in controls (OR = 1.19, 95% CI 1.03–1.37). Meta-analysis of rs1344706 by pooling all available data showed that rs1344706 was significantly associated with BD (P = 0.001). Besides, positive association of rs1344706 with schizophrenia was observed in Northern Chinese (P = 0.005). Furthermore, ZNF804A is highly expressed in human and mouse brains, especially in prenatal stage.

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Section: Discussionsupporting

confidence: 89%

Genetic association of rs1344706 in ZNF804A with bipolar disorder and schizophrenia susceptibility in Chinese populations

Rao

Yao

Ryan

et al. 2017

Sci Rep

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“…Some have provided strong support for susceptibility variants in ZNF804A in schizophrenia or bipolar disorder Riley et al, 2010;Sazci et al, 2012;Schwab et al, 2013;Williams et al, 2011;Xiao et al, 2011;Yang et al, 2013;Zhang et al, 2011a), whereas others have shown a negative association (Landaas et al, 2011;Li et al, 2011;Liou et al, 2012;Thurin et al, 2013;Zaharie et al, 2012). These differences may be caused by the type of disease, ethnicity, or sample size.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to rs1344706, the functions of other ZNF804A SNPs have been studied. The rs7597593 is located 245 bp upstream of rs1344706 (Schwab et al, 2013). The rs1602565 is located at chromosome 11q14.1 and in the intergenic region of ZNF804A (Schanze et al, 2011).…”

Section: Other Znf804a Snpsmentioning

confidence: 99%

Association between variants of zinc finger genes and psychiatric disorders: Systematic review and meta-analysis

Sun

Liang

et al. 2015

Schizophrenia Research

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“…ZNF804A was initially implicated in risk of SZ and psychosis by a GWAS, and subsequently replicated by several targeted association studies. 4, 5, 6, 7, 8, 9, 10 A report of stronger association in SZ cases with higher IQ suggests that variation in ZNF804A may confer risk of a disease subtype with relatively preserved cognition. 11 …”

Section: Introductionmentioning

confidence: 99%

Analysis of schizophrenia-related genes and electrophysiological measures reveals ZNF804A association with amplitude of P300b elicited by novel sounds

Bergen

Mesholam-Gately

et al. 2014

Transl Psychiatry

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Several genes have recently been identified as risk factors for schizophrenia (SZ) by genome-wide association studies (GWAS), including ZNF804A which is thought to function in transcriptional regulation. However, the downstream pathophysiological changes that these genes confer remain to be elucidated. In 143 subjects (68 clinical high risk, first episode or chronic cases; 75 controls), we examined the association between 21 genetic markers previously identified by SZ GWAS or associated with putative intermediate phenotypes of SZ against three event-related potential (ERP) measures: mismatch negativity (MMN), amplitude of P300 during an auditory oddball task, and P300 amplitude during an auditory novelty oddball task. Controlling for age and sex, significant genetic association surpassing Bonferroni correction was detected between ZNF804A marker rs1344706 and P300 amplitude elicited by novel sounds (beta=4.38, P=1.03 × 10−4), which is thought to index orienting of attention to unexpected, salient stimuli. Subsequent analyses revealed that the association was driven by the control subjects (beta=6.35, P=9.08 × 10−5), and that the risk allele was correlated with higher novel P300b amplitude, in contrast to the significantly lower amplitude observed in cases compared to controls. Novel P300b amplitude was significantly correlated with a neurocognitive measure of auditory attention under interference conditions, suggesting a relationship between novel P300b amplitude and higher-order attentional processes. Our results suggest pleiotropic effects of ZNF804A on risk for SZ and neural mechanisms that are indexed by the novel P300b ERP component.

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Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia

Cited by 31 publications

References 38 publications

Genetic association of rs1344706 in ZNF804A with bipolar disorder and schizophrenia susceptibility in Chinese populations

Genetic association of rs1344706 in ZNF804A with bipolar disorder and schizophrenia susceptibility in Chinese populations

Association between variants of zinc finger genes and psychiatric disorders: Systematic review and meta-analysis

Analysis of schizophrenia-related genes and electrophysiological measures reveals ZNF804A association with amplitude of P300b elicited by novel sounds

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