Association of rs6259 polymorphism with SHBG levels and Poly Cystic Ovary Syndrome in Indian population: a case control study

Association between human SHBG gene polymorphisms and risk of PCOS: a meta-analysis

“…Several studies have examined the associations of this SNP with serum SHBG concentrations and PCOS risk (Abu-Hijleh et al, 2016;Bendlova et al, 2007;Bhatnager et al, 2019;Cousin et al, 2004;Dai et al, 2015;Ferk et al, 2007;Liu et al, 2019;Martinez-Garcia et al, 2012). However, these studies have yielded inconsistent results.…”

“…After assessment, 31 articles were excluded because there was absence of genotypic data (n = 1), they were not related to SHBG gene variants (n = 23), they involved the same study cohort (n = 4) or they were not case-control studies (n = 3). Finally, 12 studies with detailed genotypic data were included in the systemic review (Abu-Hijleh et al, 2016, Baldani et al, 2015, Bendlova et al, 2007, Bhatnager et al, 2019, Cousin et al, 2004, Dai et al, 2015, Ferk et al, 2007, Liu et al, 2008, Liu et al, 2019, Martinez-Garcia et al, 2012, Xita et al, 2008, Zhao et al, 2005. These 12…”

“…Given the significant effects of gene polymorphisms on the production and function of SHBG, several studies have examined the association between different SHBG gene polymorphisms and risk of PCOS (Abu-Hijleh et al, 2016;Baldani et al, 2015;Bendlova et al, 2007;Bhatnager et al, 2019;Cousin et al, 2004;Dai et al, 2015;Ferk et al, 2007;Liu et al, 2008;Liu et al, 2019;Martinez-Garcia et al, 2012;Xita et al, 2008;Zhao et al, 2005). However, the results have been contradictory and the contribution of these gene polymorphisms to the risk of PCOS remains unclear.…”

The Association of CYP17A1, CYP19A1, and SHBG Gene Polymorphisms in Polycystic Ovary Syndrome Susceptibility: A Systematic Review and Meta-Analysis

“…The initial search strategy retrieved a total of 464 studies from all electronic databases. After reading the titles, abstracts, and full texts, we selected 26 studies ( Diamanti-Kandarakis et al, 1999 ; Marszalek et al, 2001 ; Cousin et al, 2004 ; Kahsarmiller et al, 2004 ; Tan et al, 2005 ; Bendlová et al, 2007 ; Ferk et al, 2007 ; Echiburú et al, 2008 ; Park et al, 2008 ; Jin et al, 2009 ; Unsal et al, 2009 ; Martinez-Garcia et al, 2012 ; Dasgupta et al, 2014 ; Dai et al, 2015 ; Li et al, 2015 ; Abu-Hijleh et al, 2016 ; Banerjee et al, 2016 ; Mehdizadeh et al, 2017 ; Wu et al, 2017 ; Jiao et al, 2018 ; Kaur et al, 2018 ; Bhatnager et al, 2019 ; Liu et al, 2019 ; Rahimi and Mohammadi, 2019 ; Munawar Lone et al, 2020 ; Ashraf et al, 2021 ), which included a total of 8,903 women, for inclusion in the analysis. The remaining studies were excluded: 84 were duplicates, 315 were of apparent irrelevance based on a review of abstracts and titles, four were not case-control studies, 19 lacked sufficient genotyping data, 12 included other SNPs without gene locus, two were combined with other diseases, and two had SNPs reported in less than 5 case-control study.…”

Steroid hormone-related polymorphisms associate with the development of bone erosions in rheumatoid arthritis and help to predict disease progression: Results from the REPAIR consortium

“…Whereas little is known about the role of the SHBG locus (17p13) in determining RA progression, a number of experimental studies have shown that the Fc γ R3A locus (1q23) is involved in the recognition of IgG1 and IgG3 by NK cells and macrophages and that the activation of this receptor by IgG and IgG-RF immunocomplexes might lead to the initiation of a range of sustained and harmful inflammation events that, if chronified, may cause joint and bone destruction and promote the onset of RA 72–74 . In this context and considering the number of studies reporting association of the FcγR3A rs396991 SNP with autoimmune diseases 75–82 , the response to a wide range of biologic drugs 83–89 and an exacerbated production of TNFα after stimulation of macrophages with LPS for 24 h but also the reported association of the SHBG rs6259 with serum SHBG levels 90 , we hypothesize that these SNPs might also play a relevant role in determining bone erosions and disease progression.…”