Association of rs662799 variant and <i>APOA5</i> gene haplotypes with metabolic syndrome and its components: a meta-analysis in North Africa

Hechmi, Meriem; Dallali, Hamza; Gharbi, Meriem; Jmel, Haifa; Fassatoui, Meriem; Halima, Yossra Ben; Bahri, Sonia; Bahlous, Afaf; Abid, A.; Jamoussi, H.; Barakat, Abdelhamid; Kéfi, Rym

doi:10.1042/bsr20200706

Cited by 15 publications

(12 citation statements)

References 48 publications

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“…The power analysis demonstrated that our study sample size (299 controls/295 cases) does not affect the detection of significant association. Indeed, we have previously identified significant associations of APOA5 polymorphisms with the MetS in two studies performed on the same cohort of the present work [ 26 , 27 ].…”

Section: Discussionmentioning

confidence: 63%

“…This study is conducted in the frame of MEDIGENE project, that was approved by the Ethical committee of Institut Pasteur in Tunis (Reference IPT/LR11-05/Etude 04/2013) [ 25 ]. A total of 594 participants (299 controls and 295 MetS patients), aged between 35 and 75 years, were recruited and clinically characterized as previously described [ 26 , 27 ].…”

Section: Methodsmentioning

confidence: 99%

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Association of HNF1A gene variants and haplotypes with metabolic syndrome: a case–control study in the Tunisian population and a meta-analysis

Dallali

Hechmi

Morjane

et al. 2022

Diabetol Metab Syndr

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Background Variants in the Hepatocyte Nuclear Factor 1 Alpha gene (HNF1A) are associated with lipoproteins levels and type 2 diabetes. In this study, we aimed to assess the association of HNF1A gene and haplotypes with the metabolic syndrome (MetS) and its components through an association study in the Tunisian population as well as by a meta-analysis. Methods A total of 594 Tunisian individuals were genotyped for three variants (rs1169288, rs2464196 and rs735396) located in HNF1A gene using KASPar technology. Statistical analyses were performed with R software. The association was furthermore evaluated through a meta-analysis of our results with those obtained in a Moroccan population. Results Our results showed no association between HNF1A variants and MetS in the Tunisian population. However, a significant association was observed between the variant rs735396 and a higher waist circumference. The stratified analysis according to the sex highlighted a significant association between the variant rs1169288 and high cholesterol levels only in women. Similarly, Haplotype analysis showed an association between the HNF1A minor haplotype and high total cholesterol mainly in women. Finally, our meta-analysis showed no association between HNF1A variants and MetS. Conclusions Our findings exclude the involvement of the three HNF1A variants rs1169288, rs2464196 and rs735396 in the susceptibility to MetS in our studied Tunisian population but emphasize the role of these variants in the cholesterol homeostasis with sex-specific differences, which may serve to rise clinical consideration to early statin therapy in women carrying these genetic variants.

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Section: Discussionmentioning

confidence: 63%

Section: Methodsmentioning

confidence: 99%

Association of HNF1A gene variants and haplotypes with metabolic syndrome: a case–control study in the Tunisian population and a meta-analysis

Dallali

Hechmi

Morjane

et al. 2022

Diabetol Metab Syndr

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“…Our search strategy ( Figure 1 and Methods section) identified 36 studies that met our inclusion criteria ( Bayoumi et al, 2007 ; Bayoumy et al, 2012 ; Boumaiza et al, 2012a ; Boumaiza et al, 2012b ; Ghattas et al, 2013 ; Mohamed Youssef et al, 2013 ; Zadjali et al, 2013 ; Ajjemami et al, 2014 ; Al-Daghri et al, 2014 ; Mackawy and Badawi, 2014 ; Youssef et al, 2014 ; Ajjemami et al, 2015 ; Mehanna et al, 2015 ; Alnory et al, 2016 ; Mehanna et al, 2016 ; Elouej et al, 2016a ; RaafatAbdRaboh et al, 2016 ; Elouej et al, 2016b ; Elouej et al, 2016c ; Khella et al, 2017 ; Hasan et al, 2017 ; Lakbakbi El Yaagoubi et al, 2017 ; Mackawy, 2017 ; Morjane et al, 2017 ; Ismail et al, 2019 ; Ibrahim and Bastawy, 2020 ; Salami and El Shamieh, 2019 ; ElGhareeb et al, 2019 ; Nizam et al, 2019 ; Boulenouar et al, 2019 ; Aljaibeji et al, 2020 ; Osman et al, 2020 ; Alenad et al, 2020 ; Hechmi et al, 2020 ; Kefi, 2021 ). In most cases, studies were excluded because they lacked detailed results, such as odds ratios, confidence intervals, and p -values.…”

Section: Resultsmentioning

confidence: 99%

Genetic Studies of Metabolic Syndrome in Arab Populations: A Systematic Review and Meta-Analysis

et al. 2021

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Background: The metabolic syndrome (MetS) is prevalent in Arabian populations. Several small-scale studies have been performed to investigate the genetic basis of MetS. This systematic review and meta-analysis aimed to examine whether candidate gene polymorphisms are associated with MetS susceptibility among ethnic groups of the Arabian world and to suggest possible directions for future research regarding genetic markers and MetS.Methods: A search was conducted for peer-reviewed articles that examined the genetic association of MetS in Arabian populations in the following databases: Medline, Embase, Scopus, Direct Science, Web of Science, ProQuest, and Google Scholar until March 31, 2021. Articles were eligible if they were case-control studies, which investigated MetS as a dichotomous outcome (MetS vs no MetS). To assess the quality of the studies, the Q-Genie tool (Quality of Genetic Association Studies) was used. A non-central chi2 (random-effect) distribution was used to determine the heterogeneity (H) of Q and I (Galassi et al., The American journal of medicine, 2006, 119, 812–819) statistics.Results: Our search strategy identified 36 studies that met our inclusion criteria. In most cases, studies were excluded due to a lack of statistical information such as odds ratios, confidence intervals, and p-values. According to the Q-Genie tool, 12 studies scored poorly (a score of≤35), 13 studies scored moderately ( >35 and≤45), and 12 studies had good quality ( >45 or higher). The most frequently studied genes were FTO and VDR (both included in four studies). Three SNPs indicated increased risk for MetS after calculating the pooled odds ratios: FTO-rs9939609 (odds ratio 1.49, 95% CI: 0.96–2.32); LEP-rs7799039 (odds ratio 1.85, 95% CI: 1.37–2.5); and SERPINA12-rs2236242 (odds ratio 1.65, 95% CI: 1.21–2.24). Meta-analysis studies showed no significant heterogeneity.Conclusion: There were many sources of heterogeneity in the study settings. Most of the studies had low to moderate quality because of sample size and power issues, not considering all potential sources of bias, and not providing details about genotyping methods and results. As most studies were small-scale, aimed to replicate findings from other populations, we did not find any unique genetic association between MetS and Arabian populations.

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“…In conclusion, this long-term study demonstrated that the minor C allele of the APOA5 gene (rs662799) is negatively related to the effect on triglycerides, insulin levels and HOMA-IR after consumption of a low-calorie diet with a Mediterranean pattern. Further studies are necessary to evaluate the importance of this SNV in the lipid profile and metabolic syndrome in different populations [39]. In the future, clinical guidelines will incorporate this knowledge to improve the design of nutritional interventions for obese patients, using panels of SNVs and other omic technologies [40].…”

Section: Discussionmentioning

confidence: 99%

Association of the APOA-5 Genetic Variant rs662799 with Metabolic Changes after an Intervention for 9 Months with a Low-Calorie Diet with a Mediterranean Profile

et al. 2022

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In cross-sectional studies, the genetic variant rs662799 of the APOA5 gene is associated with high serum triglyceride concentrations, and in some studies, the effect of short-term dietary interventions has been evaluated. The aim of the present investigation was to evaluate the role of this genetic variant in metabolic changes after the consumption of a low-calorie diet with a Mediterranean pattern for 9 months. A population of 269 Caucasian obese patients was recruited. Adiposity and biochemical parameters were measured at the beginning (basal level) and after 3 and 9 months of the dietary intervention. The rs662799 genotype was assessed with a dominant analysis (TT vs. CT + CC). The APOA5 variant distribution was: 88.1% (n = 237) (TT), 11.5% (n = 31) (TC) and 0.4% (n = 1) (CC). There were significant differences only in triglyceride levels at all times of the study between the genotype groups. After 3 and 9 months of dietary intervention, the following parameters improved in both genotype groups: adiposity parameters, systolic pressure, total cholesterol, LDL cholesterol, leptin, adiponectin and the leptin/adiponectin ratio. The intervention significantly decreased insulin levels, HOMA-IR and triglyceride levels in non-C allele carriers (Delta 9 months TT vs. TC + CC). i.e., insulin levels (delta: −3.8 + 0.3 UI/L vs. −1.2 + 0.2 UI/L; p = 0.02), HOMA-IR levels (delta: −1.2 + 0.2 units vs. −0.3 + 0.1 units; p = 0.02), triglyceride levels (delta: −19.3 + 4.2 mg/dL vs. −4.2 + 3.0 mg/dL; p = 0.02). In conclusion, non-C allele carriers of rs662799 of the APOA5 gene showed a decrease of triglyceride, insulin and HOMA-IR levels after consuming a low-calorie diet with a Mediterranean pattern; we did not observe this effect in C allele carriers, despite a significant weight loss.

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Association of rs662799 variant and APOA5 gene haplotypes with metabolic syndrome and its components: a meta-analysis in North Africa

Cited by 15 publications

References 48 publications

Association of HNF1A gene variants and haplotypes with metabolic syndrome: a case–control study in the Tunisian population and a meta-analysis

Association of HNF1A gene variants and haplotypes with metabolic syndrome: a case–control study in the Tunisian population and a meta-analysis

Genetic Studies of Metabolic Syndrome in Arab Populations: A Systematic Review and Meta-Analysis

Association of the APOA-5 Genetic Variant rs662799 with Metabolic Changes after an Intervention for 9 Months with a Low-Calorie Diet with a Mediterranean Profile

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