Association of rs6822844 within the <scp>KIAA1109</scp>/<scp>TENR</scp>/<scp>IL2</scp>/<scp>IL21</scp> locus with rheumatoid arthritis in the Algerian population

Louahchi, S.; Allam, Ines; Raaf, N.; Berkani, Lilya Meriem; Boucharef, A.; Abdessemed, A.; Khaldoun, N.; Bahaz, N.; Ladjouze-Rezig, A.; Nebbab, Abdelkader; Ghaffor, M; Djidjik, Réda

doi:10.1111/tan.12757

Cited by 6 publications

(9 citation statements)

References 22 publications

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“…Zhernakova et al [26] detected a decrease in frequency of the rs6822844 T-allele in RA (14.1%), and demonstrated significant association between this polymorphism and RA susceptibility (OR = 0.72, 95% CI = 0.61-0.86, P < 0.001). Moreover, Louahchi et al [22] showed a protective effect of the minor T-allele (OR = 0.39, 95% CI = 0.26-0.57), whereas the major G-allele appeared to be a risk susceptibility (OR = 2.57, 95% CI = 1.74-3.83, P < 0.001). Nevertheless, Malinowski et al [24] examined 422 RA cases and 338 controls, and found that IL-21 rs6822844 was not risk loci for RA susceptibility.…”

Section: Discussionmentioning

confidence: 96%

“…Among those, 11 articles were excluded for the following reasons: four articles were unrelated; five articles were excluded because they investigated diseases other than RA; one examined the IL-23R rs11209026 polymorphism, and one did not have complete genotype's information, three articles were classified to meta-analysis. Following the above screening, the remaining nine articles, comprising a total of 9998 cases and 10,742 controls, were selected for the meta-analysis ( Table 1 and Figure 1) [9,[19][20][21][22][23][24][25][26]. Seven studies evaluated Caucasian subjects and the remaining two investigated Asian subjects.…”

Section: Characteristics Of Selected Studiesmentioning

confidence: 99%

“…Seven studies evaluated Caucasian subjects and the remaining two investigated Asian subjects. In addition, two of the studies included information about RF and ACPA status [20,22]. All of the patients studied here were diagnosed according to the American College of Rheumatology's revised criteria [34].…”

Section: Characteristics Of Selected Studiesmentioning

confidence: 99%

“…The rs6822844 polymorphism locates in the flanking 3 -untranslated region of IL-21 [18], and may regulate the transcription and expression of the IL-21 gene, which may influence the occurrence and progress of RA. Although numbers of studies have evaluated the association between rs6822844 and RA susceptibility, reported results remain inconsistent [9,[19][20][21][22][23][24][25][26]. At the same time, considering the importance of rs6822844 G/T polymorphism in pathogenesis of RA, it is necessary and urgent to perform a comprehensive meta-analysis of all case-control studies that included both each genotype and eligible factors such as rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) status and levels.…”

Section: Introductionmentioning

confidence: 99%

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IL-21 gene rs6822844 polymorphism and rheumatoid arthritis susceptibility

Hou

Zheng

et al. 2020

Bioscience Reports

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Interleukin-21 (IL-21) is a cytokine that plays a crucial role in pathogenesis and activity of the rheumatoid arthritis (RA). Meanwhile, genetic polymorphisms in the IL-21 gene may alter its expression. Previous studies have reported conflicting results assessing the association between the IL-21 rs6822844 G/T polymorphism and RA risk. Thus, it’s necessary to perform a meta-analysis to definite above relationship. PubMed database was searched for all papers published until October 20, 2019. Nine case–control studies with 9998 cases and 10742 controls were retrieved based on the search criteria at last. Odds ratio (95% confidence interval) was used to calculate the strength of this association. Publication bias was detected using both Begg’s and Egger’s tests. Overall, the IL-21 rs6822844 G/T polymorphism was found to be significantly associated with decreased RA risk (e.g. T-allele versus G-allele: OR = 0.81, 95% CI = 0.72–0.91, P < 0.001). In addition, decreased RA risk was also detected both in Asians (eg: TT+TG versus GG: OR = 0.42, 95% CI = 0.31–0.56, P < 0.001) and Caucasians (eg: TT+TG versus GG: OR = 0.85, 95% CI = 0.80–0.91, P < 0.001). A similar trend in association was found in the source of the control and genotype method subgroups. Furthermore, subgroup analysis of rheumatoid factor status revealed a protective relationship between the IL-21 rs6822844 G/T polymorphism and RF+/RF- RA risk. A similar relationship was noted in the anti-citrullinated protein antibody status subgroup. The results of the present study suggest that the IL-21 rs6822844 G/T polymorphism was significantly associated with decreased RA susceptibility.

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Section: Discussionmentioning

confidence: 96%

Section: Characteristics Of Selected Studiesmentioning

confidence: 99%

Section: Characteristics Of Selected Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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IL-21 gene rs6822844 polymorphism and rheumatoid arthritis susceptibility

Hou

Zheng

et al. 2020

Bioscience Reports

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“…locusId=59067) and association of individual SNPs with autoimmune disorders such as systemic lupus erythematosus [17], graves disease [18]and in ammatory bowel disease [19,20] have been demonstrated. Various reports have shown a signi cant association of IL-21 polymorphisms and RA in different populations such as Netherlanders [21], Algerian [22], Columbian [19]. Further, a recent meta-analysis with including nine various studies [23] demonstrated decreased susceptibility of IL-21 rs6822844 polymorphism against the development of RA.…”

Section: Introductionmentioning

confidence: 98%

Plasma Interleukin-21 Levels and Genetic Variants Are Associated With Susceptibility to Rheumatoid Arthritis

Hao

Xie

Xia

et al. 2020

Preprint

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Background Rheumatoid Arthritis (RA ) is a chronic inflammatory condition characterised by the development of autoantibodies and an elevated spectrum of proinflammatory cytokines. Previous reports highlighted a relationship between IL-21and pathogenesis of RA. Although elevated IL-21 levels have been reported in RA patients, the association of common IL-21 genetic variants with a predisposition to RA development in the Chinese population is lacking. Materials and methods Five hundred and fourteen Chinese subjects (healthy controls: 303 and rheumatoid arthritis patients: 211) were enrolled in the study. Clinical data of patients were collected from medical records, and patients were treated as per the guidelines. IL-21 level in plasma of RA patients and healthy subjects was measured by ELISA. Results The plasma level of IL-21 was significantly higher in subjects with rheumatoid arthritis relative to healthy controls. A positive correlation was observed between IL-21 level and DAS28 score, indicating the association of the cytokine with the worsening of the disease. The prevalence of AA genotype (rs2055979) was significantly higher in RA subects compared to controls. Furthermore, elevated plasma IL-21 was observed in the rs2055979-AA genotype compared to CC type. Conclusion IL-21 plays a key function in rheumatoid arthritis pathogenesis. IL-21 rs2055979 polymorphism is associated with IL-21 plasma levels and is predisposed to RA development in Chinese population.

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Association between interleukin-21 gene rs6822844 polymorphism and rheumatoid arthritis susceptibility

et al. 2019

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Controversial results concerning the association between a polymorphism rs6822844 in the interleukin (IL) 21 (IL-21) gene and rheumatoid arthritis (RA) have existed. A meta-analysis to confirm above relationships is necessary to be performed immediately. We conducted a search in the PubMed database, covering all papers published up to 20 October 2018. Overall, six case–control studies with 3244 cases and 3431 healthy controls were included. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of this association. Publication bias was assessed with both Egger’s and Begg’s tests. After calculation, we found that IL-21 rs6822844 polymorphism could decrease RA risk in overall genetic models (allelic contrast: OR = 0.77, 95% CI = 0.62–0.97, P=0.024; TG versus GG: OR = 0.68, 95% CI = 0.50–0.92, P=0.013, and dominant genetic model: OR = 0.72, 95% CI = 0.55–0.94, P=0.016). Similarly, stratified analysis by race, source of control, significantly decreased association was found in Asians, Caucasians and hospital-based (HB) control source. Finally, in the subgroup analysis of rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) status, poorly decreased relationship was detected between IL-21 rs6822844 polymorphism and RF negative and ACPA positive RA risk, respectively. No obvious evidence of publication bias was detected in overall analysis. In summary, our study indicated that IL-21 rs6822844 polymorphism was significantly associated with decreased RA susceptibility.

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Association of rs6822844 within the KIAA1109/TENR/IL2/IL21 locus with rheumatoid arthritis in the Algerian population

Cited by 6 publications

References 22 publications

IL-21 gene rs6822844 polymorphism and rheumatoid arthritis susceptibility

IL-21 gene rs6822844 polymorphism and rheumatoid arthritis susceptibility

Plasma Interleukin-21 Levels and Genetic Variants Are Associated With Susceptibility to Rheumatoid Arthritis

Association between interleukin-21 gene rs6822844 polymorphism and rheumatoid arthritis susceptibility

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