Association of RSV-A ON1 genotype with Increased Pediatric Acute Lower Respiratory Tract Infection in Vietnam

Yoshihara, K.; Le, Minh; Okamoto, Michiko; Wadagni, Anita Carolle; Nguyen, Hien Anh; Toizumi, Michiko; Pham, Enga; Suzuki, Motoi; Nguyen, Ai T.; Oshitani, Hitoshi; Ariyoshi, Koya; Moriuchi, Hiroyuki; Hashizume, Masahiro; Dang, Duc Anh; Yoshida, Lay‐Myint

doi:10.1038/srep27856

Cited by 50 publications

(58 citation statements)

References 48 publications

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“…In our hospitalized patients, no association was found between the circulating genotypes (GA2, ON, BA) with the severity of the lower respiratory tract disease. In contrast to recent reports [24,25,26], the recently described ON genotype did not show a higher severity score. As with the influenza virus, continuous surveillance may be needed to detect new emergent genotypes and to assess their immediate effect in susceptible populations.…”

Section: Discussioncontrasting

confidence: 99%

“…Many studies have reported the molecular epidemiology and genetic variability of RSV worldwide [10,11,12,13,14,15,16,17,18,19,20], revealing the emergence and spread of new genotypes with duplication of ~60 to 70 nucleotides in this G hypervariable region for RSV-A (RSV Ontario) and RSV-B (RSV Buenos Aires) [15,19,21,22]. Although none of the variants or genotypes has been consistently associated with greater virulence or pathogenicity [13,18,22,23], some recent reports describing clinical aspects of contemporary genotypes (NA1 and ON1) have shown higher frequencies of LRTI and hospitalizations rates [24,25,26]. …”

Section: Introductionmentioning

confidence: 99%

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Genomic Loads and Genotypes of Respiratory Syncytial Virus: Viral Factors during Lower Respiratory Tract Infection in Chilean Hospitalized Infants

Espinosa

Martín

Torres

et al. 2017

IJMS

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Abstract:The clinical impact of viral factors (types and viral loads) during respiratory syncytial virus (RSV) infection is still controversial, especially regarding newly described genotypes. In this study, infants with RSV bronchiolitis were recruited to describe the association of these viral factors with severity of infection. RSV antigenic types, genotypes, and viral loads were determined from hospitalized patients at Hospital Roberto del Río, Santiago, Chile. Cases were characterized by demographic and clinical information, including days of lower respiratory symptoms and severity. A total of 86 patients were included: 49 moderate and 37 severe cases. During 2013, RSV-A was dominant (86%). RSV-B predominated in 2014 (92%). Phylogenetic analyses revealed circulation of GA2, Buenos Aires (BA), and Ontario (ON) genotypes. No association was observed between severity of infection and RSV group (p = 0.69) or genotype (p = 0.87). After a clinical categorization of duration of illness, higher RSV genomic loads were detected in infants evaluated earlier in their disease (p < 0.001) and also in infants evaluated later, but coursing a more severe infection (p = 0.04). Although types and genotypes did not associate with severity in our children, higher RSV genomic loads and delayed viral clearance in severe patients define a group that might benefit from new antiviral therapies.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genomic Loads and Genotypes of Respiratory Syncytial Virus: Viral Factors during Lower Respiratory Tract Infection in Chilean Hospitalized Infants

Espinosa

Martín

Torres

et al. 2017

IJMS

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“…Based on the pattern of disease epidemics, we surmise that the NA1 genotype (ancestor of ON1) was replaced with the ON1 genotype during 2011 to 2012. Such substitutions were observed in studies conducted in other countries [23,25].…”

Section: Discussionsupporting

confidence: 65%

“…E. Park and others RSV-positive infections has been investigated continuously through various studies [16,23,25,28,36]. We performed two analyses with respect to the clinical relevance of RSV-positive infections.…”

Section: Clinical Symptomsmentioning

confidence: 99%

Molecular and clinical characterization of human respiratory syncytial virus in South Korea between 2009 and 2014

Park

Huh

et al. 2017

Epidemiol. Infect.

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Respiratory syncytial virus (RSV) can cause serious respiratory infections, second only to influenza virus. In order to know RSV's genetic changes we examined 4028 respiratory specimens from local hospital outpatients in Gyeonggi Province, South Korea over six consecutive years by real-time one-step RT-PCR; 183 patients were positive for RSV infection. To investigate the specific distribution of RSV genotypes, we performed partial sequencing of the glycoprotein gene. Of the 131 RSV-A specimens sequenced, 61 (43·3%) belonged to the ON1 genotype, 66 (46·8%) were NA1 genotype, 3 (2·1%) were GA5 genotype, and 1 (0·7%) belonged to the GA1 genotype. Of the 31 RSV-B specimens sequenced, 29 were BA9 genotype (87·9%) and 2 were BA10 genotype (6·1%). The most common clinical symptoms were fever, cough, nasal discharge, and phlegm; multiple logistic regression analysis showed that RSV-positive infection on pediatric patients was strongly associated with cough (OR = 2·8, 95% CI 1·6-5·1) and wheezing (OR = 2·8, 95% CI 1·7-4·4). The ON1 genotype was significantly associated with phlegm (OR = 11·8, 95% CI 3·8-46·7), while the NA1 genotype was associated with the pediatric patients' gender (males, OR = 2·4, 95% CI 1·1-5·4) and presence of chills (OR = 5·1, 95% CI 1·1-27·2). RSV subgroup B was showed association with nasal obstruction (OR = 4·6, 95% CI 1·2-20·0). The majority of respiratory virus coinfections with RSV were human rhinovirus (47·2%). This study contributes to our understanding of the molecular epidemiological characteristics of RSV, which promotes the potential for improving RSV vaccines.

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“…We concluded that the A/H1N1pdm09 outbreak occurred around mid‐2009 in our study site and assumed that a large population in the community might have been infected with this new A/H1N1pdm09 strain. This may have led to the development of non‐specific antiviral immunity in the target community, which may have disrupted the circulation trend of other respiratory viruses, including influenza B. Interestingly, we also observed unusual split of RSV seasonal peak in 2010 as we previously described . Further studies would be necessary to understand the effect of A/H1N1pdm09 on respiratory virus circulation trend.…”

Section: Discussionmentioning

confidence: 54%

Influenza B associated paediatric acute respiratory infection hospitalization in central vietnam

Yoshihara

Toizumi

et al. 2019

Influenza Resp Viruses

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Background Influenza B is one of the major etiologies for acute respiratory infections ( ARI ) among children worldwide; however, its clinical‐epidemiological information is limited. We aimed to investigate the hospitalization incidence and clinical‐epidemiological characteristics of influenza B‐associated paediatric ARI s in central Vietnam. Methods We collected clinical‐epidemiological information and nasopharyngeal swabs from ARI children hospitalized at Khanh Hoa General Hospital, Nha Trang, Vietnam from February 2007 through June 2013. Nasopharyngeal samples were screened for 13 respiratory viruses using Multiplex‐ PCR s. Influenza B‐confirmed cases were genotyped by Haemagglutinin gene sequencing. We analyzed the clinical‐epidemiological characteristics of influenza B Lineages (Victoria/Yamagata) and WHO Groups. Results In the pre‐A/H1N1pdm09 period, influenza B‐associated ARI hospitalization incidence among children under five was low, ranging between 14.7 and 80.7 per 100 000 population. The incidence increased to between 51.4 and 330 in the post‐A/H1N1pdm09. Influenza B ARI cases were slightly older with milder symptoms. Both Victoria and Yamagata lineages were detected before the A/H1N1pdm09 outbreak; however, Victoria lineage became predominant in 2010‐2013 (84% Victoria vs 16% Yamagata). Victoria and Yamagata lineages did not differ in demographic and clinical characteristics. In Victoria lineage, Group1 ARI cases were clinically more severe compared to Group5, presenting a greater proportion of wheeze, tachypnea, and lower respiratory tract infection. Conclusions The current results highlight the increased incidence of influenza B‐related ARI hospitalization among children in central Vietnam in the post‐A/H1N1pdm09 era. Furthermore, the difference in clinical severity between Victoria lineage Group1 and 5 implies the importance of influenza B genetic variation on clinical presentation.

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Association of RSV-A ON1 genotype with Increased Pediatric Acute Lower Respiratory Tract Infection in Vietnam

Cited by 50 publications

References 48 publications

Genomic Loads and Genotypes of Respiratory Syncytial Virus: Viral Factors during Lower Respiratory Tract Infection in Chilean Hospitalized Infants

Genomic Loads and Genotypes of Respiratory Syncytial Virus: Viral Factors during Lower Respiratory Tract Infection in Chilean Hospitalized Infants

Molecular and clinical characterization of human respiratory syncytial virus in South Korea between 2009 and 2014

Influenza B associated paediatric acute respiratory infection hospitalization in central vietnam

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