Association of saliva 3‐methoxy‐4‐hydroxyphenylglycol levels and a later depressive state in older subjects living in a rural community: 3‐year follow‐up study

Abstract

These data indicate that high sMHPG levels at time A could be associated with a later depressive state in older men living in a community.

The Role of Norepinephrine and Its α-Adrenergic Receptors in the Pathophysiology and Treatment of Major Depressive Disorder and Schizophrenia: A Systematic Review

“…Several metabolic studies have attempted to identify potential biomarkers for MDD and schizophrenia by assessing changes in enzymatic activity in plasma and saliva. Baseline levels of MHPG in saliva were shown to positively correlate with a high Beck Depression Inventory score in men (19), which provides support to the findings that MHPG concentrations in CSF were correlated with a lifetime burden of mood swings (18). In addition, plasma MHPG has been shown to correlate with negative symptoms and cognitive impairment during early-stage schizophrenia (91).…”

“…Concentrations of 3-methoxy-4-hydroxyphenylglycol (MHPG), the major NE metabolite, in the cerebrospinal fluid (CSF) have been shown to positively correlate with lifetime mood burden, a composite measure reflecting the number, duration, and intensity of depressive episodes (18). Moreover, salivary MHPG levels in men were recently shown to correlate with depressive symptom scores (19). …”

Association of inflammatory biomarkers with depressive symptoms and cognitive decline in a community-dwelling healthy older sample: A 3-year follow-up study

“…This study was conducted as a part of the Kurogawa Study, a population-based, prospective cohort study (Li et al, 2008;Nabeta et al, 2014;Watanabe et al, 2012aWatanabe et al, , 2012b. Four hundred non-demented older people aged 65 years or over living in Kurogawa (an agrarian community belonging to Imari City, Saga Prefecture, Japan) were recruited to this study.…”

“…We have recently demonstrated that high levels of salivary 3-methoxy-4-hydroxphenylglycol (sMHPG), a metabolite of noradrenaline, were associated with a later depressive state in older men living in a community, and that high sMHPG might be associated with subsequent cognitive decline in non-demented older men (Watanabe et al, 2012a(Watanabe et al, , 2012b. We have also recently demonstrated that salivary cortisol levels at baseline had a significant positive relationship with a later depressive state in healthy older women (Nabeta et al, 2014).…”

Saliva levels of 3‐methoxy‐4‐hydroxyphenylglycol and clinical efficacy of mirtazapine or selective serotonin reuptake inhibitors in patients with major depression

“…We reported that sMHPG might be a useful marker for detecting changes in central and peripheral catecholamine metabolism associated with anxiety disorder, high scores on the General Health Questionnaire–28 (GHQ‐28), or later depressive state in elderly subjects living in a community (Yamada et al ., ; Li et al ., ; Watanabe et al ., ). However, there is no report that assesses sMHPG levels as a predictive marker for response to antidepressant therapy in patients with MDD.…”