Association of Salivary Osteopontin Levels with Glycaemic Status and Microalbuminuria - in Patients with Type 2 Diabetes Mellitus

Niranjan, G; Rajagambeeram, Reeta; Venkatkumar, Shruthi; Vijayan, Mohana Valli; Murugaiyan, Sathish Babu; Gopal, Shyam Prakash; Ramsamy, Sathiya; Alwar, V. S.

doi:10.7860/jcdr/2016/20156.8257

Cited by 3 publications

(6 citation statements)

References 22 publications

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“…With an origin not elucidated (Goga et al, 2008), some authors attributed its formation to aging, injuries, orthodontic movement (Ertas et al, 2017), and genetics (VanDenBerghe et al, 1999). What is known is that there are similarities in the calcification processes (Carson, 1998;Kohri et al, 2012;Foster et al, 2018), with an exacerbation of the inflammatory process (Gopal et al, 2016). Another highlight is that the incidence of pulp stones is higher in patients with diabetes and kidney disease (Nakajima et al, 2013), including urolithiasis (Movahhedian et al, 2018;Gabardo et al, 2019), and coronary artery disease (Alsweed et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…One sample of saliva of each participant (n = 80) was collected, and three trained examiners performed this phase. Patients were instructed to perform proper oral hygiene and refrain from consumption of alcoholic beverages in the 12 h prior to the collection (Gopal et al, 2016).…”

Section: Saliva Collection and Sialometric Analysismentioning

confidence: 99%

“…Labtest Diagnóstica R (Lagoa Santa, MG, Brazil) colorimetric kits were used for sialochemical analyses of URE, GLU, TPT, alkaline phosphatase (Alpdemir et al, 2018), creatinine (CRE), salivary amylase (SAM; Gopal et al, 2016), URA, calcium (Ca), and iron (Biscaglia et al, 2016). The Quimifos kit (Ebram Produtos Laboratoriais Ltda., São Paulo, SP, Brazil) was used for phosphorus (P) measurement.…”

Section: Sialochemical Analysesmentioning

confidence: 99%

“…Interestingly, the incidence of pulp stones is higher in patients with diabetes and kidney disease (Nakajima et al, 2013), including urolithiasis (Movahhedian et al, 2018;Gabardo et al, 2019), and coronary artery disease (Alsweed et al, 2019), possibly due to the inflammatory process common to them (Gopal et al, 2016). The association between them and certain systemic conditions is also supported by the fact that the mechanism of mineralization of pulp stones is similar to calcifications in other organs in the body (Carson, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Sialometric and Sialochemical Analysis in Individuals With Pulp Stones

Gabardo

Kublitski

Sette

et al. 2020

Front. Cell Dev. Biol.

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The aim of this study was to analyze the saliva of patients with pulp stones, with sialometric and sialochemical tests. Eighty individuals, aged between18 and 65 years, of both sexes, were investigated. Patients were included in the pulp stone group when radiographic examination was suggestive of pulp stones in at least one permanent tooth, whereas those without this alteration were considered controls. Saliva was collected by stimulation, followed by salivary flowrate (SFR) and pH analysis tests. The organic components, such as urea (URE), glucose (GLU), total proteins (TPTs), alkaline phosphatase, creatinine (CRE), salivary amylase (SAM), and uric acid (URA), and the inorganic components, such as calcium, iron, and phosphorus, were evaluated by colorimetric techniques in an ultraviolet-visible (UV-vis) spectrophotometer. Differences among pulp stones and control groups were compared using Student's t-test, with a significance level of p < 0.05. In both groups prevailed the female. Statistically significant differences between groups were observed for pH (p = 0.027), SFR (p = 0.002), alkaline phosphatase (p = 0.008), and URA (p = 0.005). None of the inorganic components showed significant difference (p > 0.05). In the analyses stratified by sex, difference between groups was observed for pH (p = 0.007) and URA (p = 0.003) in women. In conclusion, sialometric and sialochemical alterations occurred in patients with pulp stones, with significantly higher levels of pH, SFR, alkaline phosphatase, and URA.

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Section: Discussionmentioning

confidence: 99%

Section: Saliva Collection and Sialometric Analysismentioning

confidence: 99%

Section: Sialochemical Analysesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sialometric and Sialochemical Analysis in Individuals With Pulp Stones

Gabardo

Kublitski

Sette

et al. 2020

Front. Cell Dev. Biol.

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“…OPN, also called secreted phosphoprotein 1 (SPP1), belongs to the small integrin-binding ligand N-link glycoprotein (SIBLINGs) family and has a high stability in the blood and saliva. 8–10 OPN exists in a negligible quantity in healthy brains, but it is quickly up-regulated in macrophages and/or activated microglia in a multitude of brain pathologies, including neonatal hypoxia-ischemia, stroke, electrolytic lesion, TBI, and the Alzheimer’s disease models. 11–17 We hypothesized that OPN may be a good blood biomarker in pediatric TBI, given the important role of neuroinflammation in TBI, generally healthy conditions in pre-TBI children (hence a low background of plasma OPN), integrin-mediated brain-to-blood transport of OPN, and high stability of OPN in biofluids (Figure 1(a)).…”

Section: Introductionmentioning

confidence: 99%

Plasma osteopontin may predict neuroinflammation and the severity of pediatric traumatic brain injury

Gao

Zhang-Brotzge

Wali

et al. 2019

J Cereb Blood Flow Metab

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Traumatic brain injury (TBI) is the leading cause of death in children and adolescents in developed countries, but there are no blood-based biomarkers to support the diagnosis or prognosis of pediatric TBI to-date. Here we report that the plasma levels of osteopontin (OPN), a phosphoprotein chiefly secreted by macrophages and/or activated microglia, may contribute to this goal. In animal models of TBI, while OPN, fibrillary acidic protein (GFAP), and matrix metalloproteinase 9 (MMP-9) were all readily induced by controlled cortical impact in the brains of one-month-old mice, only OPN and GFAP ascended in the blood in correlation with high neurological severity scores (NSS). In children with TBI (three to nine years of age, n = 66), the plasma levels of OPN, but not GFAP, correlated with severe TBI (Glasgow Coma Score ≤ 8) and intracranial lesions at emergency department. In addition, the plasma OPN levels in severe pediatric TBI patients continued to ascend for 72 h and correlated with mortality and the days requiring ventilator or intensive care unit support, whereas the plasma GFAP levels lacked these properties. Together, these results suggest that plasma OPN outperforms GFAP and may be a neuroinflammation-based diagnostic and prognostic biomarker in pediatric TBI.

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Interactions of the Osteokines, Glucose/Insulin System and Vascular Risk Networks in Patients With Newly Diagnosed Type 2 Diabetes (VNDS 15)

Zusi,

Bonetti,

Rinaldi

et al. 2024

Diabetes Metabolism Res

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Background and AimBone as an endocrine organ regulates metabolic processes independently of mineral metabolism through the production/release of proteins collectively named ‘osteokines’. Relevant connections were reported between the insulin/glucose system, calcification of the atherosclerotic plaque, and several osteokines. We aimed to test the hypothesis that the osteokine network could be involved in beta‐cell function, insulin sensitivity, and vascular damage in a cohort of people with newly diagnosed type 2 diabetes (T2D).Subjects and MethodsIn 794 drug‐naive, GADA‐negative, newly‐diagnosed T2D patients (mean ± SD age: 59 ± 9.8 years; BMI: 29.3 ± 5.3 kg/m2; HbA1c: 6.6 ± 1.3%) we assessed: plasma concentration of osteocalcin (OCN), osteopontin (OPN), RANKL, and its putative decoy receptor osteoprotegerin (OPG); insulin sensitivity (SI) by hyperinsulinemic euglycemic clamp; beta cell function (BCF), estimated by OGTT minimal modelling and expressed as derivative (DC) and proportional (PC) control. Echo‐doppler of carotid and lower limb arteries were also performed in 708 and 701 subjects, respectively.ResultsOCN, RANKL and OPG were significantly associated with PC (p < 0.02); OCN was positively related to DC (p = 0.018). OPG was associated with lower IS (p < 0.001). Finally, the higher RANKL levels, the greater was the severity of atherosclerosis in common carotid artery (p < 0.001). Increased OPG and OPN concentrations were related to subclinical atherosclerosis in peripheral arteries of lower limbs (p = 0.023 and p = 0.047, respectively).ConclusionThese data suggest that, in patients with newly diagnosed T2D, the osteokine network crosstalks with the glucose/insulin system and may play a role in modulating the atherosclerotic process.

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Association of Salivary Osteopontin Levels with Glycaemic Status and Microalbuminuria - in Patients with Type 2 Diabetes Mellitus

Cited by 3 publications

References 22 publications

Sialometric and Sialochemical Analysis in Individuals With Pulp Stones

Sialometric and Sialochemical Analysis in Individuals With Pulp Stones

Plasma osteopontin may predict neuroinflammation and the severity of pediatric traumatic brain injury

Interactions of the Osteokines, Glucose/Insulin System and Vascular Risk Networks in Patients With Newly Diagnosed Type 2 Diabetes (VNDS 15)

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