Association of <scp>ADIPOQ</scp>, leptin, <scp>LEPR</scp>, and resistin polymorphisms with obesity parameters in Hammam Sousse Sahloul Heart Study

Zayani, Nesrine; Omezzine, Asma; Boumaiza, Imen; Achour, Ons; Raîs, L.; Rejeb, Jaleleddine Ben; Rejeb, N.; Abdelaziz, Ahmed Ben; Bouslama, Ali

doi:10.1002/jcla.22148

Cited by 28 publications

(23 citation statements)

References 77 publications

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“…Previous studies also have been unable to detect the association between G2548A and obesity in Polish, Spanish, and Japanese population in which consistent with our data (Cieslak et al 2012;Mizuta et al 2008;Portolés et al 2006). However, the contradicting results were observed in Brazilian, Tunisian, Turkish, Taiwanese and French which G2548A variant was referred as one of the obesity markers (Boumaiza et al 2012;Hinuy et al 2008;Mammès et al 2000;Sahin et al 2013;Wang et al 2006;Zayani et al 2017). Besides, previous researchers suggested G allele was susceptible to the obesity in particular population (Boumaiza et al 2012) whereas, in some populations, they claimed that A allele was related to obesity risks (Hinuy et al 2008;Wang et al 2006).…”

Section: Discussionsupporting

confidence: 82%

Effects of Leptin Gene Variants on Obesity and Its Attributes in Malay Population

Taib¹

2018

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Leptin is a hormone that regulates the energy intake and expenditure which is encoded by leptin gene. Leptin gene variants were studied comprehensively in relation with body weight status, but the evidences were indecisive. This study was to determine the association between leptin gene variants, G2548A, H1328080 and A19G with obesity and its attributes in Terengganu, Malaysian population. This study involved a total of 249 Malay subjects (101 healthy adults with normal BMI as the control group and 148 overweight and obese subjects). The anthropometrics data were obtained, blood samples were collected for genetic markers and lipid profile analyses. PCR-RFLP technique was performed to determine the genotype and allele distribution of leptin gene variants. The genotypic and allelic frequencies of leptin gene variants presented no significant difference between groups, G2548A (P = 0.93 and 0.74); H1328080 (P = 0.58 and 0.56); and A19G (P = 0.72 and 0.38) correspondingly. However, there was statistical significant difference between triglyceride level and genotypes of G2548A variant (P = 0.016); between total cholesterol level and H1328080 genotypes (P = 0.027). In addition, multivariate logistic regression projected the male gender (adjusted OR= 26.27; CI= 1.06-1.25; P = 0.009), waist circumference (adjusted OR = 1.15; CI = 1.06-1.25; P = 0.001) and body fat percentage (adjusted OR = 1.43; CI = 1.20-1.70; P<0.001) were the independent risk factors for obesity. The data suggest G2548A, H1328080 and A19G variants were not associated with obesity. However, waist circumference and body fat percentage may increase risk for obesity in Malay population.

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Section: Discussionsupporting

confidence: 82%

Effects of Leptin Gene Variants on Obesity and Its Attributes in Malay Population

Taib¹

2018

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“…14 Polymorphisms in FTO, MC4R, ABCA1, and ADIPOQ were reported to be significantly associated with obesity and Type 2 diabetes mellitus (-T2DM). [15][16][17][18] Similarly, VDR variants, another set of moststudied SNPs, have been identified to be associated with many diseases, including obesity and increased adiposity. 19,20 GNPDA2, PFKP, and TCF7L2 showed a strong association with BMI, body weight, and waist circumference in genome association studies in Europe and Indian Asian.…”

Section: Introductionmentioning

confidence: 99%

<p>Protective Association of Single Nucleotide Polymorphisms rs1861868-FTO and rs7975232-VDR and Obesity in Saudi Females</p>

Asoom¹,

Afandi²,

Abdulhadi³

et al. 2020

IJGM

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Background: Obesity is a major health threat worldwide. It predisposes individuals to diabetes, cardiovascular complications, and cancer. Genetic and environmental factors are responsible for the increasing incidence of obesity. In this study, we investigated the genetic factors associated with obesity in young Saudi women. Subjects and Methods: In this cross-sectional study, 131 young Saudi female students were recruited. Body mass index (BMI), waist-hip ratio, blood glucose, triglyceride, cholesterol, HDL, LDL, and vitamin D3 levels of the subjects were determined. Twelve SNPs of different genes that showed a correlation with obesity in different population were tested, namely GNPDA2 (rs10938397), TCF7L2 (rs10885409), FTO (rs1477196), ADIPOQ (rs1501299), MC4R (rs17782313), ABCA1 (rs1800977), FTO (rs1861868), VDR (rs2228570), VDR (rs731236), VDR (rs7975232), ADIPOQ (rs266729), and PFPK (rs6602024). Student's t-test was conducted for all parameters. Pearson correlation was performed to identify the correlated variables. The frequencies of different risk alleles were determined by direct counting of the test allele divided by the total number of alleles and compared. Results: Only two SNPs, rs1861868 of FTO and rs7975232 of VDR, of the twelve tested SNPs showed significant protective associations with the BMI with odds ratio 0.3886 (0.1761-0.8572); p 0.0192 and odds ratio 0.4563 (0.2343-0.8888); p 0.0211, respectively. Conclusion: The current study showed that minor alleles, "T" of FTO and "A" of VDR, might be protective factors against increased BMI in young Saudi female subjects. To elucidate this association, further studies with larger sample size involving both sexes are required.

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“… 38 , 42 For example, a study that was conducted on overweight and obese children showed significantly higher leptin levels in rs7799039 AA genotype compared with other genotypes. 38 In addition, AA genotype was associated with higher risk of malnutrition inflammation syndrome, 24 obesity 25 and metabolic syndrome. 26 On the other hand, the CC genotype has been shown to be associated with dyslipidemia in patients using atypical antipsychotic agents.…”

Section: Discussionmentioning

confidence: 99%

“…Among LEP gene polymorphisms is rs7799039. The clinical significance of this polymorphism is well documented as it was associated with higher risk of several diseases including malnutrition inflammation syndrome, 24 obesity 25 and metabolic syndrome. 26 In addition, rs7799039 was associated with blood lipid levels among Southern Chilean population, 27 dyslipidemia in patients using atypical antipsychotic agents and lipid profile modulation induced by soluble fiber intake.…”

Section: Introductionmentioning

confidence: 99%

Association between leptin gene rs7799039 polymorphism and lipid profile changes induced by isotretinoin treatment in acne patients

Khabour¹,

Alzoubi²,

Firoz³

et al. 2018

TCRM

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IntroductionIsotretinoin, a vitamin A-derived medication, is one of the effective treatments for severe acne. However, in a fraction of patients, this treatment causes significant adverse effects. Leptin is a pro-inflammatory cytokine that plays a role in apoptosis of adipose cells and sebaceous lipid metabolism. Thus, genetic polymorphisms in the leptin (LEP) gene may modulate the response to isotretinoin therapy. Here, we explore the contribution of rs7799039 polymorphism of the LEP gene in the adverse effects of the oral isotretinoin therapy among acne patients.Materials and methodsClinical parameters were obtained from 200 patients before and after isotretinoin treatment for acne. In addition, circulatory lipid profile and aspartate transaminase (AST) and alanine aminotransferase (ALT) enzymes from acne subjects before and 1 month after oral isotretinoin treatment were also measured.ResultsAn association between the rs7799039 polymorphism and the following lipid parameters: high-density lipoprotein (HDL) at baseline and after treatment, HDL % change, low-density lipoprotein % change and total cholesterol % change (P < 0.05). In addition, there was an association between the LEP polymorphism and higher AST and ALT at baseline and after treatment (P < 0.05).ConclusionIn conclusion, rs7799039 LEP polymorphism might modulate lipid parameters and liver enzymes, but not other major side effects of oral isotretinoin therapy.

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Association of ADIPOQ, leptin, LEPR, and resistin polymorphisms with obesity parameters in Hammam Sousse Sahloul Heart Study

Abstract: ADIPOQ, LEP, and RETN gene polymorphisms were associated with obesity parameters in HSHS population.

Cited by 28 publications

References 77 publications

Effects of Leptin Gene Variants on Obesity and Its Attributes in Malay Population

Effects of Leptin Gene Variants on Obesity and Its Attributes in Malay Population

<p>Protective Association of Single Nucleotide Polymorphisms rs1861868-FTO and rs7975232-VDR and Obesity in Saudi Females</p>

Association between leptin gene rs7799039 polymorphism and lipid profile changes induced by isotretinoin treatment in acne patients

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