Association of <scp>HLA‐B27</scp> and <scp>ERAP1</scp> with ankylosing spondylitis susceptibility in Beijing Han Chinese

Zhang, Z.; Dai, Dongfa; Yu, Kun; Yuan, Fang; Jin, Jiajia; Ding, Lin; Yu, Hao; Liang, Fei; Liu, Ningjing; Zhao, Xiaoming; Long, Ji Rong; Yang, Xi; Sun, Yuying

doi:10.1111/tan.12334

Cited by 25 publications

(26 citation statements)

References 22 publications

(36 reference statements)

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“…A literature search in the PubMed database resulted in the identification of 22 studies; 12 studies met the study inclusion criteria, including four studies from European populations and eight studies from Asian populations (two from Korean, six from Chinese populations), including the present study 9, 25, 26, 30, 31, 34, 35, 37, 38, 39, 40. Ten studies were excluded (seven studies due to lack of data and three studies having duplicate data).…”

Section: Resultsmentioning

confidence: 99%

ERAP1/ERAP2 and RUNX3 polymorphisms are not associated with ankylosing spondylitis susceptibility in Chinese Han

Liu

et al. 2018

Clinical and Experimental Immunology

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SummaryPrevious studies show that endoplasmic reticulum‐associated aminopeptidase (ERAP1/ERAP2) and runt‐related transcription factor 3 (RUNX3) gene polymorphisms are associated with AS (ankylosing spondylitis) in European Caucasians. However, contradictory results were reported in different Asian populations. The purpose of this study was to determine whether eleven candidate single nucleotide polymorphisms (SNPs) in ERAP1/ERAP2 and six in RUNX3 genes confer susceptibility to AS with or without acute anterior uveitis (AAU) [AS+AAU+ or AS+AAU–] in Chinese Han. Therefore, a case–control association study was performed in 882 AS+AAU–, 884 AS+AAU+ and 1727 healthy controls. Genotyping was performed using the iPLEXGold genotyping assay. A meta‐analysis was performed to assess the association of polymorphisms of ERAP1 with AS susceptibility in Asian populations. No association was found between SNPs of ERAP1/ERAP2/RUNX3 and susceptibility of AS with or without AAU. A case–control study between patients with human leucocyte antigen HLA‐B27‐positive and healthy controls also failed to demonstrate an association of the tested SNP with AS with or without AAU. Moreover, a meta‐analysis showed that there was no association of rs30187, rs27037, rs27980, rs27434 and rs27582 in ERAP1 with AS in Chinese Han. Taken together, 17 SNPs in ERAP1/ERAP2 and RUNX3 genes did not confer disease susceptibility to AS in Chinese Han.

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Section: Resultsmentioning

confidence: 99%

ERAP1/ERAP2 and RUNX3 polymorphisms are not associated with ankylosing spondylitis susceptibility in Chinese Han

Liu

et al. 2018

Clinical and Experimental Immunology

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“…A previous genome-wide association study revealed that ERAP1 polymorphisms are associated with AS at a high level of statistical significance [3], but more recent studies, in different ethnic groups, have produced mixed results [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. In our previous meta-analysis, we found that the rs27044, rs17482078, rs10050860, rs30187, and rs2287987 polymorphisms of ERAP1 were associated with the development of AS in Europeans [28].…”

Section: Discussionmentioning

confidence: 99%

“…Two studies were excluded because one used the data analyzed in another study and another did not have extractable allele data. Thus, 20 studies met the inclusion criteria (Table 1) [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]27]. However, one of these studies contained data on three groups [13] and two studies had data on two different groups [17].…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

“…A genome-wide association study revealed that two single-nucleotide polymorphisms (SNPs) (rs27044, rs30187) of ERAP1 were significantly associated with AS, and demonstrated that rs17482078, rs10050860, and rs2287987 polymorphisms also trended toward association with AS [3]. Although some studies have demonstrated that SNPs of ERAP1 are associated with AS susceptibility, others disagree [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. It would appear that allelic frequencies often differ substantially between populations, and ethnicity-specific association studies are needed to confirm genetic associations in different populations.…”

Section: Introductionmentioning

confidence: 99%

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Associations between ERAP1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis

Lee

Song

2016

Clin Rheumatol

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The aim of this study was to determine whether 11 polymorphisms of endoplasmic reticulum aminopeptidase 1 (ERAP1) confer susceptibility to ankylosing spondylitis (AS). The authors conducted meta-analyses on associations between ERAP1 polymorphisms and AS susceptibility by using fixed and random effects models. A total of 19 articles were included in this meta-analysis, which comprised a total of 19,902 AS patients and 39,750 controls. The meta-analysis revealed a significant association between AS and the minor alleles of the rs30187 polymorphism in all study subjects (OR = 1.255, 95 % CI = 1.147-1.373, P = 8.0 × 10(-8)). Stratification by ethnicity led to the identification of a significant association between this polymorphism and AS in European patients (OR = 1.283, 95 % CI = 1.237-1.331, P < 1.0 × 10(-9)). Meta-analyses of the results for the rs27044, rs10050860, rs2287987, rs17482078, and rs26653 polymorphisms showed the same pattern that was found for rs30187. Interestingly, the rs27037 polymorphism was significantly associated with AS susceptibility in both European and Asian patients. Meta-analysis showed a significant association between AS and the minor alleles of the rs27980 and rs27582 polymorphisms in the East Asian patients (OR = 0.904, 95 % CI = 0.818-0.999, P = 0.047; OR = 0.871, 95 % CI = 0.772-0.982, P = 0.024, respectively) (Table 2). However, these polymorphisms have not been studied in Europeans. This meta-analysis shows that the ERAP1 polymorphisms are associated with the development of AS in Europeans and East Asians.

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“…Research on correlation between HLA-B27 subtypes and AS showed that HLA-B*27:04, B*27:05, and B*27:02 were highly detected in Beijing Han population [29], and Qi J et al discovered that AS patients with HLA-B*2705 demonstrated an older age of onset and had a higher risk of uveitis and dactylitis than did AS patients with HLA-B*2704 [30]. Further researches were required to explore the association between SpA-related uveitis and HLA-B27 subtypes.…”

Section: Discussionmentioning

confidence: 99%

Anti-TNFα agents and methotrexate in spondyloarthritis related uveitis in a Chinese population

et al. 2015

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This study seeks to evaluate the clinical characteristics of spondyloarthritis (SpA)-related uveitis in a cohort from South China and to assess the efficacy and safety of therapies based on TNF blockers. SpA patients with uveitis admitted to a south China hospital were enrolled. Demographic information, clinical characteristics, laboratory findings, intraocular inflammation, visual acuity, macular thickness, and treatments were documented. Of the 1,036 SpA patients reviewed, 182 had uveitis. Ankylosing spondylitis (AS) was the most common subtype. Unilateral uveitis was found in 51 cases (51/182, 28.0%), and unilateral alternating uveitis was found in 75 cases (75/182, 41.2%). Half of the cases were recurrent uveitis (52.2%), and acute onset was common (76.4%). The most serious complication was vision loss (0.5%). No significant difference in disease activity was found between the SpA patients with or without uveitis. Predominant improvements were found in cases treated with all three anti-TNFs (infliximab, adalimumab, and etanercept) and anti-TNFs plus methotrexate (MTX). Monotherapy of methotrexate was not adequate for inducing remission. Monotherapy of etanercept was not as effective as adalimumab and infliximab, mainly in the prevention of recurrence. No significant difference in effectiveness was found among the three anti-TNFs if MTX was added. Etanercept plus MTX were well tolerated. Infliximab and adalimumab were associated with more tuberculosis and/or hepatitis flares. Uveitis is common in SpA patients. Severe complications may develop in prolonged and intractable cases. Treatments based on anti-TNFs had good clinical response, and better safety documentation were observed in etanercept plus MTX compared to the other two anti-TNF monoclonal antibodies plus MTX.

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Association of HLA‐B27 and ERAP1 with ankylosing spondylitis susceptibility in Beijing Han Chinese

Cited by 25 publications

References 22 publications

ERAP1/ERAP2 and RUNX3 polymorphisms are not associated with ankylosing spondylitis susceptibility in Chinese Han

ERAP1/ERAP2 and RUNX3 polymorphisms are not associated with ankylosing spondylitis susceptibility in Chinese Han

Associations between ERAP1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis

Anti-TNFα agents and methotrexate in spondyloarthritis related uveitis in a Chinese population

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