Association of HLA‐DRB1 and HLA‐DQB1 with red‐blood‐cell alloimmunization in the Czech population

Abstract

For the first time, we confirmed the association of HLA-DRB1*15 with RBC antibody multiresponder status and found HLA-Class II associations for three frequent RBC antibody combinations. Our data support the concept that HLA restriction plays an important role in the response to RBC alloantigens.

HLA‐DRB1*09:01 allele is associated with anti‐E immunization in a Chinese population

“…More recently, Maluskova and coworkers found a higher frequency of HLA‐DRB1*09 in E‐immunized persons than in controls (3.8% vs. 0.8%). In our study, HLA‐DRB1*09:01 was similarly confirmed to have a strong association with induction of anti‐E in the Chinese population …”

“…Our experimental results were consistent with the results of the other two studies on HLA‐DRB1 association and E immunization . However, the predicted results by TEPITOPEpan were not in accordance with our experiment results.…”

“…Previous studies have indicated that alloimmunization against E antigen is associated with recipient HLA-DRB1 polymorphisms in the European population. 20,21 Schonewille and colleagues identified that the frequency of HLA-DRB1*09 significantly increased in E-immunized persons compared to controls (8.8% vs. 2.5%). 20 More recently, Maluskova and coworkers found a higher frequency of HLA-DRB1*09 in E-immunized persons than in controls (3.8% vs. 0.8%).…”

“…In our study, HLA-DRB1*09:01 was similarly confirmed to have a strong association with induction of anti-E in the Chinese population. 21 The TEPITOPEpan is a software to predict MHCbinding peptides, identify HLA ligands and T-cell epitopes, and recognize binding cores. At a threshold of 2% (high stringency), no E-derived anchor peptide was predicted to bind the HLA-DRB1 molecules tested; however, only at a threshold of 5% was one E-derived anchor peptides (W848-S856) predicted to bind HLA-DRB1*04:05, DRB1*04:17, and DRB1*13:02 molecules.…”

Susceptible and protective HLA‐DR and HLA‐DQ alleles for Fya alloimmunization in the Croatian population

“…To confirm association with only Fy a alloimmunization and not with the formation of multiple RBC antibodies, shown by other authors for DRB1*15 and DQB1*06, an analysis was performed among patients with Fy a monoresponders. Alleles DRB1*04, DRB1*15, DQB1*03 and DQB1*06 were shown to be increased, while DRB1*03 and DQB1*02 allele were decreased in patients when compared to both control groups.…”