Association of sedentary behavior with the risk of breast cancer in women: update meta-analysis of observational studies

Zhou, Yingchun; Zhao, Hongyang; Peng, Cheng

doi:10.1016/j.annepidem.2015.05.007

Cited by 50 publications

(56 citation statements)

References 52 publications

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“…The sedentary lifestyle is associated with 8% of breast cancer cases (38). Cohen et al (39) in 2013 showed in white women that increased physical activity was associated with less chance of developing breast cancer, while sedentary lifestyle was associated with increased risk.…”

Section: Discussionmentioning

confidence: 99%

Lifestyle and vitamin D dosage in women with breast cancer

et al. 2016

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Key words:Breast cancer. Vitamin D. Menopause. Physical activity. Case-control study. Palabras clave:Cáncer de mama. Vitamina D. Menopausia. Actividad física. Estudio de casos y controles. ResumenIntroducción: la estrategia de prevención del cáncer de mama sigue siendo el factor clave para el diagnóstico precoz y el método más efi caz para el seguimiento de la enfermedad. Objetivo: este estudio tuvo como objetivo evaluar el nivel de vitamina D asociado con el cáncer de mama en las mujeres. Métodos: este estudio de casos y controles hospitalarios se llevó a cabo con 181 mujeres con cáncer de mama y 197 controles sanas. Se estudió el nivel de vitamina D, calcio, fósforo y la dosis de suero PTH; se recopilaron de datos relacionados con el estilo de vida y com la historia de las pacientes, además se realizaron mediciones antropométricas. El análisis univariante (Chi-cuadrado probabilidades y primas ratio) y el análisis multivariado se realizó mediante regresión logística multivariante. Resultados: este estudio muestra un valor más alto de vitamina D en los controles de salud (26,9 mg/dl) que en las mujeres con cáncer de mama (24,8 mg/dl). Se encontraron más mujeres con sufi ciente vitamina D (34,85%) en el grupo control que en el grupo de cáncer. Usando el modelo de regresión logística múltiple, la historia familiar de cáncer de mama (OR 36,37; IC del 95%: 4,75 a 278,50) y la menopausia (OR 5,17; IC del 95%: 2,72 a 9,80) se halló una relación directa con el cáncer de mama, mientras que el nivel de vitamina D (OR 0,95; IC del 95%: 0,91 a 0,99) y la actividad física moderada (OR 0,31; IC del 95%: 0,10 a 0,93) mantienen las asociaciones inversas con la enfermedad. Conclusión: el estado de vitamina D y la práctica de actividad física moderada se consideraron factores de protección para el cáncer de mama. Sin embargo, la menopausia y la historia familiar de cáncer de mama se consideran un factor de riesgo para el cáncer de mama. AbstractIntroduction: The prevention strategy of breast cancer is still the key factor for early diagnosis and the most effective method for tracking the disease.Objective: This study aimed to evaluate the association vitamin D level with breast cancer in women.Methods: This hospital case-control study was conducted with 181 women with breast cancer and 197 healthy controls. Vitamin D status, calcium, phosphorus and PTH serum dosage and data collection related to lifestyle and patient's history, besides anthropometric measurements were performed. Univariate analysis (Chi-square and raw odds ratio) and multivariate analysis were performed through multivariate logistic regression. Results: This study shows a higher value of vitamin D in health controls (26.9 mg/dL) than in breast cancer women (24.8 mg/dL). Higher numbers of women with suffi cient vitamin D status (34.85%) were found in control group than cancer group. Using the multiple logistic regression model, the family history of breast cancer (OR 36.37,) and menopause (OR 5.17, 95% CI 2.72-9.80) had a direct association with breast cancer, wh...

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Section: Discussionmentioning

confidence: 99%

Lifestyle and vitamin D dosage in women with breast cancer

et al. 2016

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“…A 2014 meta-analysis that examined the association between occupational sitting time and breast cancer reported a summary risk estimate of 1.03 for the highest versus lowest levels of sedentary work, and three subsequent studies (two cohort and one case–control) have also found no association between sitting time at work, total sitting time and/or time spent sitting watching television and the risk of breast cancer 12 30 31. An updated meta-analysis published in 2015 found that occupational sedentary behaviour was associated with a 10% increased risk of breast cancer 10. Thus, research to date indicates that occupational sedentary behaviour is unlikely to have a large influence on overall breast cancer risk.…”

Section: Discussionmentioning

confidence: 99%

“…However, research investigating sedentary behaviour and breast cancer risk has produced inconsistent results. Two meta-analyses of 21 cohort and case–control studies and 3 cohort studies, respectively, found that females with the highest levels of sedentary behaviour have a slightly higher risk of breast cancer compared with females with the lowest sedentary levels 9 10. A third meta-analysis of 13 cohort and case–control studies concluded there was no association between sedentary behaviour and breast cancer risk 4.…”

Section: Introductionmentioning

confidence: 99%

Sedentary work and the risk of breast cancer in premenopausal and postmenopausal women: a pooled analysis of two case–control studies

et al. 2016

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“…Recent research indicates that sedentary time (behaviors that require little to no additional energy expenditure beyond basal metabolic rate) may be associated with increased breast cancer risk [4,5]. Previous research suggests the impact of sedentary behavior on health outcomes may not be due only to the absence of regular recreational physical activity [6–8].…”

Section: Introductionmentioning

confidence: 99%

Sedentary time and postmenopausal breast cancer incidence

Nomura

Dash

Sheppard

et al. 2017

Cancer Causes Control

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PURPOSE The objective of this study was to evaluate the prospective association between sedentary time and postmenopausal breast cancer incidence, and whether associations differ by race/ethnicity, physical activity levels and body measurements. METHODS The Women’s Health Initiative Observational Study (WHI-OS) is a prospective cohort among women ages 50–79 years at baseline (1994–1998) (analytic cohort=70,233). Baseline questionnaire data was used to estimate time spent sitting and total sedentary time. Associations between time spent sitting and invasive breast cancer incidence overall (N= 4,115 cases through September 2015), and by hormone receptor subtypes, were investigated using Cox proportional hazards regression. Analyses were replicated stratified by race/ethnicity, body measurements, and physical activity. RESULTS Among women in this study, 34.5% reported ≤5 hours/day sitting, 40.9% reported 6–9 hours/day and 24.7% reported ≥10 hours/day. Time spent sitting (≥10 vs. ≤5 hours/day adjusted HR=1.00, 95% CI: 0.92–1.09) was not associated with breast cancer incidence, regardless of hormone receptor subtype. Associations did not differ by race/ethnicity, physical activity or body measurements. CONCLUSIONS Results from this study do not support an association between sedentary time and breast cancer incidence.

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Association of sedentary behavior with the risk of breast cancer in women: update meta-analysis of observational studies

Cited by 50 publications

References 52 publications

Lifestyle and vitamin D dosage in women with breast cancer

Lifestyle and vitamin D dosage in women with breast cancer

Sedentary work and the risk of breast cancer in premenopausal and postmenopausal women: a pooled analysis of two case–control studies

Sedentary time and postmenopausal breast cancer incidence

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