Association of Selenium and Risk of Esophageal Cancer: A Review

Younesian, Ommolbanin; Younesian, Samareh; Hosseinzadeh, Sara; Joshaghani, Hamidreza

doi:10.29252/mlj.14.1.1

Cited by 3 publications

(4 citation statements)

References 103 publications

(90 reference statements)

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“…Selenium functions as an anti-oxidant and plays a possible chemo-preventive role against cancer through scavenging reactive oxygen species (ROS), thereby preventing damage to the DNA and occurrence of mutations [ 34 ]. The effects of selenium status on cancer were studied in several clinical trials and epidemiologic studies in humans, suggesting the beneficial effects of higher selenium status in preventing the recurrence of lung cancer [ 35 ] and patients with different cancer types [ 11 ]. We thus hypothesized that selenium might reduce ROS production and DNA damage against ESSC.…”

Section: Discussionmentioning

confidence: 99%

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Potential Chemotherapeutic Effect of Selenium for Improved Canceration of Esophageal Cancer

Ahsan

Liu

et al. 2022

IJMS

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Esophageal squamous cell carcinoma is the most common type of esophageal cancer and accounts for 5% of malignant tumor deaths. Recent research suggests that chronic inflammation and DNA damage may drive the onset of esophageal squamous cell carcinoma, implying that lowering chronic inflammation and DNA damage compounds may provide chemo-prevention. According to epidemiological and experimental evidence, selenium is linked to a lower risk of several malignancies, including esophageal squamous cell carcinoma. However, its exact mechanism is still unclear. In the present study, we used cell lines and a 4-NQO mice model to explore the anti-cancer mechanism of four types of selenium. Our findings indicated that selenium inhibited the proliferation, colony formation, and ROS level of ESCC cell lines in a time-dependent manner. Intriguingly, selenium treatment impeded 4-NQO-induced high-grade intraepithelial neoplasia and reduced the number of positive inflammatory cells by preserving DNA from oxidative damage. In addition, selenium significantly decreased the expression of Ki-67 and induced apoptosis. This study demonstrates that selenium has a significant chemo-preventive effect on ESCC by reducing high-grade dysplasia to low-grade dysplasia. For the first time, selenium was shown to slow down the progression of esophageal cancer by lowering inflammation and oxidative DNA damage.

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Section: Discussionmentioning

confidence: 99%

“…Selenium (Se) is a vital and unique trace element that helps to prevent various tumor malignancies, including ESCC [ 10 , 11 ]. Previous studies described a significant inverse correlation between serum selenium levels and the risk of ESCC in China’s high-risk areas [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Potential Chemotherapeutic Effect of Selenium for Improved Canceration of Esophageal Cancer

Ahsan

Liu

et al. 2022

IJMS

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“…The association between older age and COVID-19 mortality can be due to age-related dysfunction in T lymphocyte and B lymphocyte and increased type 2 cytokines production, which leads to impaired control of virus replication and ultimately leads to poor outcome [ 25 ]. Selenium is an essential trace element that exerts its main function on the health of the body through selenocysteine in the structure of selenoproteins [ 26 , 27 ]. Adequate levels of selenium are essential for central nervous system function, male reproduction, endocrine system, muscle function, cardiovascular system, and immune system [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Decreased Serum Selenium Levels of COVID-19 Patients in Comparison with Healthy Individuals

Younesian

Khodabakhshi

Abdolahi

et al. 2021

Biol Trace Elem Res

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Background Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the cause of the COVID-19 pandemic and is the cause of increased mortality, especially among elderly patients and those who have severe complications, such as chronic pulmonary obstruction, hypertension, diabetes, and cancer. Nutrition, especially micronutrients, plays an important role in reducing mortality and complications from COVID-19 because micronutrients strengthen our immune system and nutritional status is an important factor that affects the outcome of patients with COVID-19. Among micronutrients, selenium has an important effect on both intrinsic and acquired immunity. Host selenium deficiency affects the viral genome and increases the virulence of viruses. We have investigated the serum selenium levels in COVID-19 patients and healthy control individuals. Methods A total of 50 patients with COVID-19 infection were included in this study. During hospitalization, 13 patients died (non-survivor group) and 37 patients recovered (survivor group). We assessed the serum selenium levels in 50 COVID-19 patients and 50 healthy individuals by Agilent SpectrAA-240 Z atomic absorption spectrometer. Results The serum selenium level was significantly lower in COVID-19 patients (77. 8 ± 13.9 μg/L) as compared to healthy control individuals (91.7 ± 16.7 μg/L), but there was no significant difference between the survivor and non-survivor groups. Also, there was no significant relationship between serum selenium levels and laboratory findings of COVID-19 patients. Conclusions These results suggest that decreased serum selenium levels may be a risk factor for the COVID-19 infection, but there was no significant relationship between selenium and severity and mortality of COVID-19 disease.

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“…These studies suggest that high levels of selenium in this area may play a possible role in EC pathogenesis. 25,26,27,28 The case-control study nested within the Golestan Cohort reported that toenail selenium concentrations did not differ significantly between cases of ESSC in highrisk areas and healthy subjects, and there was no association between toenail selenium concentrations and the ESCC risk in this population. 29 Another study in Golestan province showed that in the high-risk areas of EC, the association between selenium and the risk of developing ESSC was non-linear and U-shaped.…”

Section: Discussionmentioning

confidence: 95%

Serum Selenium, Vitamin A, and Vitamin E Levels of Healthy Individuals in High‐ and Low‐Risk Areas of Esophageal Cancer

Torshizi

Younesian

Aboomardani

et al. 2022

Middle East J Dig Dis

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Background: Esophageal cancer is one of the main causes of cancer mortality in the world. Golestan province, in the northern part of Iran, has the highest esophageal cancer rate in the world. The north and south districts of Golestan province can be classified as low and high-risk areas for esophageal cancer. One of the potential risk factors for esophageal cancer in this population is a nutrient-deficient diet. Dietary antioxidant compounds such as selenium, vitamin E, vitamin A, and β-carotene are reactive oxygen species (ROC) scavengers that play a key role in cellular responses to oxidative stress and preventing DNA damage. This study aims to compare the serum levels of selenium, vitamin E, and vitamin A in healthy individuals in high and low-risk areas of esophageal cancer. Methods: This study is a population of 242 healthy individuals. Serum selenium levels were assessed by atomic absorption spectroscopy. Vitamin E and A were assessed by reversed-phase high-performance liquid chromatography. Results: Vitamin E levels of healthy individuals in high-risk areas were significantly lower than in low-risk areas, while there was no significant difference between the selenium and vitamin A levels of healthy individuals in high-risk areas and low-risk areas. Also, there was no significant difference between selenium, vitamin E, and vitamin A levels in urban and rural areas and men and women in Golestan province. Conclusion: High levels of selenium with lower levels of vitamin E, along with other risk factors, may be associated with esophageal squamous cell carcinoma in high-risk areas of Golestan province.

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Association of Selenium and Risk of Esophageal Cancer: A Review

Cited by 3 publications

References 103 publications

Potential Chemotherapeutic Effect of Selenium for Improved Canceration of Esophageal Cancer

Potential Chemotherapeutic Effect of Selenium for Improved Canceration of Esophageal Cancer

Decreased Serum Selenium Levels of COVID-19 Patients in Comparison with Healthy Individuals

Serum Selenium, Vitamin A, and Vitamin E Levels of Healthy Individuals in High‐ and Low‐Risk Areas of Esophageal Cancer

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