Association of selenoprotein S gene polymorphism with ischemic stroke in a Chinese case–control study

Abstract

Previous studies showed that selenoprotein S (SELS) was associated with a range of inflammatory markers, and its gene expression was influenced by a polymorphism in the promoter region. The genetic basis of the ischemic stroke has now been largely determined, so the aim of the study was to examine the role of SELS genetic variants in the ischemic stroke risk in a Chinese population. We conducted a case-control study with 239 ischemic stroke patients and 240 controls. Two single-nucleotide polymorphisms (SNPs) in SELS genes were analyzed for association with the risk of ischemic stroke in the Chinese Han population. No evidence of ischemic stroke association was observed with the SNP rs34713741. Interestingly, the strongest evidence showed that SELS SNP rs4965814 was associated with ischemic stroke (P < 0.05). We found a significant association with increased ischemic stroke risk in women carrying the CC genotype of rs4965814 [hazard ratio: 2.43(1.03-5.75)]; a similar trend was also found in men carrying the TC genotype of rs4965814 [hazard ratio: 1.81(1.06-3.08)]. SNP rs4965814 of SELS may affect the susceptibility to ischemic stroke. Understanding the inflammatory mechanisms of ischemic stroke may give new therapeutic targets to pharmacologists.

Associations and interactions between variants in selenoprotein genes, selenoprotein levels and the development of abdominal aortic aneurysm, peripheral arterial disease, and heart failure

“…There is an increasing number of studies showing the role of selenoprotein gene variants in CVD. The SELENOS SNPs in the promoter region were linked to the development of diabetes [ 24 ], ischemic stroke [ 21 , 22 ], coronary heart disease [ 22 , 23 ], as well as carotid and coronary atherosclerosis [ 23 ]. The SEPP1 rs3877899 and rs7579 SNPs have been associated with metabolic phenotypes related to diabetes [ 28 ], while different GPX4 variants were linked with the concentration of inflammatory biomarkers [ 27 ], glutathione peroxidase activity [ 45 ], lipid metabolism [ 46 ], as well as obesity [ 45 ], cerebral stroke [ 25 ], and endothelial dysfunction [ 26 ].…”

“…Among them, interactions with the manganese superoxide dismutase gene ( SOD2 ) variants are observed the most frequently [ 18 – 20 ]. There is also growing evidence on the role of polymorphisms in selenoprotein genes in CVDs [ 21 – 29 ].…”

The influence of nutrigenetics on biomarkers of selenium nutritional status

“…106,107 A substitution C > T occurs in the promoter region of the SELENOS gene (rs34713741) that has been associated with an increased risk of rectal, 102 colorectal, and gastric cancer 108 as well as ischemic stroke. 109 Another relevant polymorphism is the rs28665122, located in the promoter region of the SELENOS gene, also known as -105G/A. This SNP has been correlated with plasma IL-1, IL-6, and TNF-α levels 106 , an increased susceptibility to Hashimoto´s Thyroiditis 110 , preeclampsia in Norwegian women 107 and an increased risk of gastric cancer.…”

Selenoprotein S: a therapeutic target for diabetes and macroangiopathy?

“…However, they found that the risk ratio of the development of CVD in females carrying SELENOS SNP rs8025174 was 2.95; the risk ratio of the development of ischemic stroke in the population carrying SNP rs7178239 was 1.75, and the risk ratio in females reached 3.35. Li et al [ 73 ] used the Chinese population as subjects to perform a case-controlled study (ischemic stroke group n = 239; non-ischemic stroke control group n = 240) and showed that SELENOS SNP rs4965814 could increase the risk of ischemic stroke by 1.54-fold; this risk ratio in females reached 2.43. These results were similar to those of Silander et al [ 74 ].…”