Association of Serotonin Receptors with Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-analysis

Hou, Yachen; Xiong, Ping; Gu, Xue; Huang, Xin; Wang, Min; Wu, Jing

doi:10.1007/s11596-018-1912-3

Cited by 34 publications

(22 citation statements)

References 133 publications

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“…Dysfunction of the serotonergic neurotransmission plays a role in numerous mental and behavioral disorders (Dell’Osso et al, ; Hou et al, ; Zmudzka et al, ). MAOA was an important enzyme involved in the synthesis and metabolism of serotonin.…”

Section: Discussionmentioning

confidence: 99%

“…It has been well documented that dysfunctions in serotonergic neurotransmission are involved in numerous mental and behavioral disorders (Dell’Osso, Carmassi, Mucci, & Marazziti, ; Hou et al, ; Zmudzka, Salaciak, Sapa, & Pytka, ). The mitochondrial enzyme monoamine oxidase A (MAOA) subtype catalyzes the degradation process of various monoamine neurotransmitters and plays a key role in the metabolism of serotonin.…”

Section: Introductionmentioning

confidence: 99%

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Administration of moclobemide facilitates fear extinction and attenuates anxiety‐like behaviors by regulating synaptic‐associated proteins in a rat model of post‐traumatic stress disorder

Xiao

Han

Shi

2020

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Post‐traumatic stress disorder (PTSD) is a long‐lasting mental disorder and accompanied by worse fear extinction. Enhanced fear memory or poor fear extinction are typical features of PTSD. Dysfunction of the serotonergic neurotransmitter system is involved in numerous mental and behavioral disorders. Monoamine oxidase A (MAOA) is important in the metabolism of serotonin and play an important role in behavious. The aim of this study was to explore the change of MAOA and effect of MAOA on fear memory in PTSD. We used single prolonged stress (SPS) to create animal model of PTSD. A startle/fear box and elevated plus maze were used to observe fear memory and anxiety level, respectively. We examined the expression of MAOA and synaptic marker protein, as well as the immunological activity of MAOA in the infralimbic cortex (IL) area, which is a critical brain region involved in emotions, especially fear regulation. We found increased anxiety‐like behavior, dysfunction in fear extinction, and increased MAOA in SPS rats. After treatment with moclobemide (a selective inhibitor of MAOA), SPS rats showed significantly improved fear memory and decreased anxiety‐like behavior, which indicated that moclobemide could reverse fear extinction deficit and attenuate abnormally increased levels of anxiety caused by SPS in short term. On the contrary, decreased PSD‐95 and SYN1 expression in the IL region were also reversed by moclobemide. These results suggest that increased MAOA play a negative role in fear extinction and levels of anxiety in PTSD, which may be involved in change in PSD‐95 and SYN1.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Administration of moclobemide facilitates fear extinction and attenuates anxiety‐like behaviors by regulating synaptic‐associated proteins in a rat model of post‐traumatic stress disorder

Xiao

Han

Shi

2020

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“…Furthermore, attentional problems were seen when exposed to Triptans, a 5-HT 1B/1D receptor agonist. Indeed, genetic mutations within these receptors have been associated with the risk of ADHD [302,303].…”

Section: Gestational Factors Can Influence the Risk To Develop Neuropmentioning

confidence: 99%

Gestational Factors throughout Fetal Neurodevelopment: The Serotonin Link

Hanswijk

Spoelder

Shan

et al. 2020

IJMS

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Serotonin (5-HT) is a critical player in brain development and neuropsychiatric disorders. Fetal 5-HT levels can be influenced by several gestational factors, such as maternal genotype, diet, stress, medication, and immune activation. In this review, addressing both human and animal studies, we discuss how these gestational factors affect placental and fetal brain 5-HT levels, leading to changes in brain structure and function and behavior. We conclude that gestational factors are able to interact and thereby amplify or counteract each other’s impact on the fetal 5-HT-ergic system. We, therefore, argue that beyond the understanding of how single gestational factors affect 5-HT-ergic brain development and behavior in offspring, it is critical to elucidate the consequences of interacting factors. Moreover, we describe how each gestational factor is able to alter the 5-HT-ergic influence on the thalamocortical- and prefrontal-limbic circuitry and the hypothalamo-pituitary-adrenocortical-axis. These alterations have been associated with risks to develop attention deficit hyperactivity disorder, autism spectrum disorders, depression, and/or anxiety. Consequently, the manipulation of gestational factors may be used to combat pregnancy-related risks for neuropsychiatric disorders.

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“…ADHD is a highly prevalent psychiatric disorder. Recent research has shown that, apart from changes in central nervous dopaminergic activity as well as other neurotransmitter systems (1) the underlying neurobiology of ADHD as a disorder is also subject to changes in 5-HT neurotransmission (2)(3)(4)(5)(6)(7)(8)(9). Research on the role of the amino acid (AA) tryptophan (TRP, the physiological precursor of 5-HT) and related brain 5-HT synthesis) have used acute tryptophan depletion (ATD).…”

Section: Introductionmentioning

confidence: 99%

Acute Tryptophan Depletion Moja-De: A Method to Study Central Nervous Serotonin Function in Children and Adolescents

et al. 2020

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Serotonin (5-HT) is widely implicated as a key neurotransmitter relevant to a range of psychiatric disorders and psychological processes. The role of central nervous 5-HT function underlying these processes can be examined through serotonergic challenge methodologies. Acute tryptophan depletion (ATD) is a key challenge method whereby a diminished dietary intake of tryptophan-the amino acid precursor to brain 5-HT synthesis-results in temporary diminished central nervous 5-HT synthesis. While this particular methodology has been used in adult populations, it was only recently that modifications were made to enable the use of ATD in child and adolescent populations. Additionally, the Moja-De modification of the ATD challenge methodology has demonstrated benefits over other ATD techniques used previously. The aim of this protocol paper is to describe the ATD Moja-De methodology in detail, its benefits, as well as studies that have been conducted to validate the procedure in child and adolescent samples. The ATD Moja-De protocol provides a potential methodology for investigating the role of central nervous 5-HT via manipulation of brain tryptophan availability in human psychopathology from a developmental viewpoint.

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Association of Serotonin Receptors with Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-analysis

Cited by 34 publications

References 133 publications

Administration of moclobemide facilitates fear extinction and attenuates anxiety‐like behaviors by regulating synaptic‐associated proteins in a rat model of post‐traumatic stress disorder

Administration of moclobemide facilitates fear extinction and attenuates anxiety‐like behaviors by regulating synaptic‐associated proteins in a rat model of post‐traumatic stress disorder

Gestational Factors throughout Fetal Neurodevelopment: The Serotonin Link

Acute Tryptophan Depletion Moja-De: A Method to Study Central Nervous Serotonin Function in Children and Adolescents

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