2011
DOI: 10.1378/chest.10-2973
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Association of SERPINE2 With Asthma

Abstract: A sthma and COPD are complex human airway diseases that are infl uenced by various genetic and environmental susceptibility factors. In 1961, Orie and colleagues 1 proposed that these diseases were different expressions of one basic pulmonary disease whose expression in individuals was shaped differently depending on a combination of endogenous (ie, host) and exogenous (ie, environmental) factors. This view, which became known as the "Dutch hypothesis," suggests that overlapping clinical features of asthma and… Show more

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Cited by 20 publications
(24 citation statements)
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“…39 Furthermore, some of the genes we have studied are associated not only with COPD but also with asthma. [40][41][42] We cannot fully exclude that observed associations with lung function in our birth cohort might be ascribed to asthma. However, this is unlikely because none of the SNPs were associated with doctor-diagnosed asthma at age 8 years (data not shown).…”
Section: Discussionmentioning
confidence: 85%
“…39 Furthermore, some of the genes we have studied are associated not only with COPD but also with asthma. [40][41][42] We cannot fully exclude that observed associations with lung function in our birth cohort might be ascribed to asthma. However, this is unlikely because none of the SNPs were associated with doctor-diagnosed asthma at age 8 years (data not shown).…”
Section: Discussionmentioning
confidence: 85%
“…10,35 Some PN-1 variants have been associated with lung function among patients with COPD and asthma. 36 We thus propose that PN-1 is a new important player in pulmonary fibrosis and hypothesize that the biological activity of PN-1 could be of importance in the progression of the pathology. Such a role could be deleterious, regarding the impact of PN-1 on the induction of ECM proteins such as fibronectin or, in contrast, beneficial in view of the impact of PN-1 on thrombin activity.…”
Section: Serpine2 In Fibrotic Fibroblastsmentioning
confidence: 94%
“…SERPINE2 is a member of a gene family encoding serpins, highly conserved proteins that help maintain tissue integrity by controlling the activity of proteases in diverse biological processes, in particular by inhibiting serine proteases such as trypsin. SERPINE2 has a known link to airway obstruction, with strong evidence of association with COPD[ 34 ] and some evidence of association with childhood asthma[ 35 ]. Our findings support an association with a marker of lung restriction too, FVC, in both adults and children, in line with previous findings of an association with FVC in children that could not be replicated[ 36 ].…”
Section: Discussionmentioning
confidence: 99%