Association of serum 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population

Tao, Minfang; Zeng, Zhen; Ke, Yingying; He, Jia; Fu, Wen‐Zhen; Zhang, Changqing; Zhang, Zhenlin

doi:10.1038/aps.2013.13

Cited by 19 publications

(22 citation statements)

References 37 publications

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“…Vitamin D may increase insulin receptor expression to improve insulin responsiveness in cells for glucose transport (34,35). Moreover, taking together literature and present data, we can conclude that vitamin D3 supplementation in vitamin deficiency led to improvements in several laboratory and clinical parameters of PCOS (36,37).…”

Section: @ C I C E D I Z I O N I I N T E R N a Z I O N A L Isupporting

confidence: 59%

Endocrine effects of two different treatments in polycystic ovary syndrome

Panico¹

2016

GIOG

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Introduction. One of the main alterations of the polycystic ovary syndrome (PCOS) is the insulin-resistance (IR).Purpose. This study aimed to examine the effect of two different treatments on metabolic and endocrine variables in patients affected by PCOS. Materials and methods. 80 patients affected by PCOS were enrolled for the study. They have been divided in two groups, on the basis of their treatment: D-chiro-inositol (DCI) (500 mg) + myoinositol (MI) (200 mg) + revifast® (80 mg) + folic acid (200 mcg) + manganese (5 mg) + vitamin D (12,5 mcg) per day in galenic formulation (A group) and D-chiro-inositol (500 mg) + myoinositol (200 mg) + lipoic acid (150 mg) + folic acid (200 mcg) + manganese (5 mg) per day (B group). Some clinical, biochemical, endocrine parameters were evaluated at baseline and after 6 months of observation.Results. The statistical analysis pointed out, after 6 months of treatment, a significant difference between the two groups in respect of: serum FSH (p = 0,001 vs p = 0,066), prolactin (p = 0,023 vs p = 0,878), DHEAS (p = 0,010 vs p = 0,004 vs p = 0,730). As compared with group B, in group A after 6 months of treatment there were statistically significant reductions of hirsutism (96 vs 68% respectively, p< 0,001) and acne (72 vs 62%, respectively p<0,001). Conclusions. Our study suggested that the concomitant supplementation of revifast® and vitamin D in association with myoinositol and D-chiro-inositol can ameliorate endocrine features in patients affected by PCOS.RIASSUNTO: Effetti endocrini di due differenti trattamenti terapeutici in pazienti affette da sindrome dell'ovaio policistico.

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Section: @ C I C E D I Z I O N I I N T E R N a Z I O N A L Isupporting

confidence: 59%

Endocrine effects of two different treatments in polycystic ovary syndrome

Panico¹

2016

GIOG

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“…The lower limit of detection for 25(OH)D was 4 ng/mL (10 mmol/L). The intraand interassay CVs were 1.4% and 2.9% for PTH, 2.5% and 3.5% for β-CTX, 2.9% and 4.0% for osteocalcin, and 2.3% and 2.8% for P1NP, respectively [17,19,20] .…”

Section: Blood Measurementmentioning

confidence: 93%

“…Of these 1396 women, 39 failed the initial screening, leaving 1357 subjects with detected serum osteocalcin. All the subjects belonged to the Chinese Han ethnic group and signed informed consent documents before entering the study [17] . All subjects completed a questionnaire, providing information on age, medical history, etc.…”

Section: Subjectsmentioning

confidence: 99%

Serum osteocalcin levels are inversely associated with plasma glucose and body mass index in healthy Chinese women

et al. 2014

Acta Pharmacol Sin

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Aim: Osteocalcin, a biochemical marker of bone formation, has been suggested to be involved in the regulation of energy metabolism. The aim of this study was to investigate the possible association between serum osteocalcin and markers of glucose and lipid metabolism in a large sample of healthy Chinese women. Methods: A total of 2032 healthy Chinese women in Shanghai, aged 20-94 (including 1396 discovery-study subjects and 636 postmenopausal women for a reduplication analysis) were recruited. Their serum osteocalcin, calcium and the relevant measurements were analyzed. A Spearman correlation analysis was performed between osteocalcin and the other markers of energy metabolism including triglyceride, total cholesterol, fasting plasma glucose (FPG), serum insulin, body mass index and homeostasis model assessment-insulin resistance. Separate multiple regression analyses were performed with data from the discovery and reduplication subjects to determine whether serum osteocalcin concentration was an independent predictor of the glucose or lipid metabolism markers. Results: For the discovery-study subjects, serum osteocalcin was found to be negatively associated with weight (r=-0.08, P=0.002), BMI (r=-0.13, P<0.001) and FPG (r=-0.13, P=0.001). Similar results were also found in the reduplication subjects P=0.016; P=0.003; P<0.001). In the multiple regression analysis, serum osteocalcin was revealed as a potential independent predictor for FPG (β=-0.07 and -0.210 for discovery and reduplication, respectively, P<0.01) and BMI (β=-0.127 and -0.299 for discovery and reduplication, respectively, P<0.01). Conclusion: Serum osteocalcin is negatively associated with weight BMI and FPG in healthy Chinese women. Therefore, osteocalcin might contribute to obesity and diabetes.

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“…The lower limit of detection for 25(OH)D was 4 ng/mL (10 mmol/L). The intra- and interassay CVs were 1.4 and 2.9% for PTH, 2.5 and 3.5% for β-CTX, and 2.9 and 4.0% for osteocalcin, respectively [35,36,37]. …”

Section: Methodsmentioning

confidence: 99%

Associations of Serum Osteocalcin and Polymorphisms of the Osteocalcin Gene with Bone Mineral Density in Postmenopausal and Elderly Chinese Women

Zhang

He²,

Fu³

et al. 2016

Lifestyle Genomics

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Background: The aims of this study were: (1) to evaluate the association of serum osteocalcin with bone mineral density (BMD) and markers of bone metabolism in postmenopausal and elderly Chinese women, and (2) to observe the relationships of single-nucleotide polymorphisms (SNPs) in and around the osteocalcin gene with osteocalcin and BMD. Methods: A cross-sectional study was conducted with 725 postmenopausal Chinese women. Five SNPs (rs1543294, rs1800247, rs759330, rs2842880, and rs933489) of the osteocalcin gene were genotyped. Serum osteocalcin and intact parathyroid hormone (PTH), 25-hydroxyvitamin D [25(OH)D], and type I collagen containing cross-linked C-telopeptide (β-CTX) were measured. The BMD of the lumbar spine and proximal femur was measured by dual-energy X-ray absorptiometry. Results: Osteocalcin was positively correlated with serum phosphorus (p = 0.001), alkaline phosphatase (ALP; p < 0.001), PTH (p = 0.002) and β-CTX (p < 0.001), and negatively correlated with BMD at the lumbar spine (p < 0.001) and total hip (p = 0.002). No significant association was obtained between the SNPs, haplotypes of the osteocalcin gene, and BMD or osteocalcin. Conclusion: Our results suggest that osteocalcin was positively correlated with serum phosphorus, ALP, PTH, and β-CTX, but negatively correlated with BMD at the lumbar spine and total hip. Common genetic variants of the osteocalcin gene may not be a major contributor to variations in serum osteocalcin or BMD in postmenopausal and elderly Chinese women.

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Association of serum 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population

Cited by 19 publications

References 37 publications

Endocrine effects of two different treatments in polycystic ovary syndrome

Endocrine effects of two different treatments in polycystic ovary syndrome

Serum osteocalcin levels are inversely associated with plasma glucose and body mass index in healthy Chinese women

Associations of Serum Osteocalcin and Polymorphisms of<b> </b>the<b><i> Osteocalcin</i></b> Gene with Bone Mineral Density in Postmenopausal and Elderly Chinese Women

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