Association of serum 8-hydroxy-2′-deoxyguanosine levels with the presence and severity of coronary artery disease

Xiang, Fei; Xie, Shuanglun; Wang, Jingfeng; Nie, Ruqiong; Yuan, Zuyi; Lin, Yongqing; Zhang, Jun

doi:10.1097/mca.0b013e328344b615

Cited by 38 publications

(36 citation statements)

References 24 publications

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“…We also used an ELISA to assess 8‐oxo‐2′‐dG in plasma samples, as conventional chromatographic methods do not have the sensitivity to measure plasma levels. Although the circulating levels of 8‐oxo‐2′‐dG detailed in this study are similar to those reported in cross‐sectional studies using ELISA‐based assays in patients with diabetes mellitus25, 26, 27 and other settings,28, 29, 30, 31, 32 it is understood that ELISA overestimates 8‐oxo‐2′‐dG when compared with high‐sensitivity mass spectroscopy 33. This is partly because of the former method including DNA fragments containing 8‐oxo‐2′‐dG, in addition to free 8‐oxo‐2′‐dG, as well as the presence of interfering compounds in plasma.…”

Section: Discussionsupporting

confidence: 84%

Relationship Between Plasma 8‐OH‐Deoxyguanosine and Cardiovascular Disease and Survival in Type 2 Diabetes Mellitus: Results From the ADVANCE Trial

Thomas

Woodward

et al. 2018

JAHA

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Background8‐Oxo‐2′‐deoxyguanosine (8‐oxo‐2′‐dG) is a biomarker of oxidative DNA damage that is associated with cardiovascular disease and premature mortality in the general population. Although oxidative stress has a proven role in cardiovascular complications in diabetes mellitus, evidence for a relationship between plasma 8‐oxo‐2′‐dG and major cardiovascular outcomes in diabetes mellitus is weak.Methods and ResultsA case‐cohort study was performed in 3766 participants with prevalent diabetes mellitus in the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation) trial (http://ClinicalTrials.gov number NCT00145925). The hazard ratios for mortality and major acute cardiovascular events were derived using Cox regression models. During a median of 5 years of follow‐up, 695 (18.4%) participants in this enriched cohort died (including 354 deaths from cardiovascular disease). Individuals with higher levels of 8‐oxo‐2′‐dG were more likely to die. After adjusting for cardiovascular disease risk factors, the hazard ratio for a 1‐SD increase in plasma 8‐oxo‐2′‐dG was 1.10 (95% confidence interval, 1.01–1.20; P=0.03). This was driven by an independent association between plasma 8‐oxo‐2′‐dG and cardiovascular death (hazard ratio, 1.23; 95% confidence interval, 1.10–1.37 [P<0.001]). By contrast, no association was seen between 8‐oxo‐2′‐dG and noncardiovascular disease death (of which cancer was the major single cause). 8‐Oxo‐2′‐dG was also not significantly associated with either nonfatal myocardial infarction or nonfatal stroke.ConclusionsIn adults with type 2 diabetes mellitus, increased levels of 8‐oxo‐2′‐dG are independently associated with all‐cause mortality and cardiovascular mortality in adults with longstanding type 2 diabetes mellitus who participated in the ADVANCE trial, consistent with the role of oxidative damage in the development and progression of cardiovascular decompensation in diabetes mellitus.Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT00145925.

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Section: Discussionsupporting

confidence: 84%

Relationship Between Plasma 8‐OH‐Deoxyguanosine and Cardiovascular Disease and Survival in Type 2 Diabetes Mellitus: Results From the ADVANCE Trial

Thomas

Woodward

et al. 2018

JAHA

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“…However, there is still a lack of studies evaluating the risk of CAD in women or comparing the two sexes, which also includes studies of the markers of oxidative stress status (5). Recent studies that have explored the relationship between oxidative stress biomarkers and CAD have included women (16)(17)(18)(19)(20)(21)(22)(23)(24), but they are not specifically targeted to exploring cardiovascular physiopathology in female patients. The most important limitation of such studies is the lack of any information on the menopausal status of the women enrolled.…”

Section: Discussionmentioning

confidence: 99%

Sex-related differences in association of oxidative stress status with coronary artery disease

Vassalle

Sciarrino

Bianchi

et al. 2012

Fertility and Sterility

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“…For example, serum 8-OH-2dG levels are significantly higher in patients with coronary artery disease [47] and serum concentrations are higher in patients with diabetes [48]. Increased lymphocyte and serum γH2AX levels were also linked to diseases of accelerated ageing, suggesting that oxidative DNA damage may be a common feature of these diseases [49].…”

Section: Figurementioning

confidence: 99%

Mechanisms of development of multimorbidity in the elderly

2015

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In ageing populations many patients have multiple diseases characterised by acceleration of the normal ageing process. Better understanding of the signalling pathways and cellular events involved in ageing shows that these are characteristic of many chronic degenerative diseases, such as chronic obstructive pulmonary disease (COPD), chronic cardiovascular and metabolic diseases, and neurodegeneration. Common mechanisms have now been identified in these diseases, which show evidence of cellular senescence with telomere shortening, activation of PI3K-AKT-mTOR signalling, impaired autophagy, mitochondrial dysfunction, stem cell exhaustion, epigenetic changes, abnormal microRNA profiles, immunosenescence and low grade chronic inflammation ("inflammaging"). Many of these pathways are driven by chronic oxidative stress. There is also a reduction in anti-ageing molecules, such as sirtuins and Klotho, which further accelerates the ageing process. Understanding these molecular mechanisms has identified several novel therapeutic targets and several drugs have already been developed that may slow the ageing process, as well as lifestyle interventions, such as diet and physical activity. This indicates that in the future new treatment approaches may target the common pathways involved in multimorbidity and this area of research should be given high priority. Thus, COPD should be considered as a component of multimorbidity and common disease pathways, particularly accelerated ageing, should be targeted. @ERSpublications Multimorbidities share many common underlying mechanisms that may be linked to common causes such as oxidative stress

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Association of serum 8-hydroxy-2′-deoxyguanosine levels with the presence and severity of coronary artery disease

Abstract: In conclusion, the serum 8-OHdG levels are increased in patients with CAD and are associated with the severity of coronary artery stenosis. 8-OHdG might serve as an independent factor for predicting CAD.

Cited by 38 publications

References 24 publications

Relationship Between Plasma 8‐OH‐Deoxyguanosine and Cardiovascular Disease and Survival in Type 2 Diabetes Mellitus: Results From the ADVANCE Trial

Relationship Between Plasma 8‐OH‐Deoxyguanosine and Cardiovascular Disease and Survival in Type 2 Diabetes Mellitus: Results From the ADVANCE Trial

Sex-related differences in association of oxidative stress status with coronary artery disease

Mechanisms of development of multimorbidity in the elderly

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