Association of Serum and Follicular Fluid Leptin Concentrations with Granulosa Cell Phosphorylated Signal Transducer and Activator of Transcription 3 Expression in Fertile Patients with Polycystic Ovarian Syndrome

Li, Mei-Gen; Ding, Guo‐Lian; Chen, Xijing; Lu, Xi-Ping; Liang, Dong; Dong, Minyue; Yang, Xiaofu; Lu, Xiu-e; Huang, He‐Feng

doi:10.1210/jc.2007-0978

Cited by 36 publications

(28 citation statements)

References 31 publications

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“…Recent work has considered whether women who have had recurrent miscarriage have IR [7,8,9]. However, only FG has been examined.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Recurrent Miscarriage and Insulin Resistance

Wang¹,

Zhao²,

Li³

et al. 2011

Gynecol Obstet Invest

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Aims: To investigate the differences in insulin resistance between women with recurrent miscarriage and those with normal pregnancy. Methods: Pregnant women with a history of recurrent miscarriage were included in the patient group (n = 97), while those with no history of abnormal pregnancy were included in the control group (n = 52). Both groups consented to undertake an oral glucose tolerance test and insulin-releasing test between the 5th and 13th weeks of pregnancy. Results: (1) Levels of fasting plasma glucose, fasting plasma insulin, homeostasis model assessment of insulin resistance index, and homeostasis model assessment β function were not statistically significantly different (p < 0.05) between the two groups. (2) The area under the curve of glucose and area under the curve of insulin were higher in the patient group than in the control group. The composite insulin sensitivity index of the patient group was lower than that of the control group. The differences in these three parameters between the groups were statistically significant (p < 0.05). Conclusion: Women with a history of recurrent miscarriage are at an increased risk for insulin resistance during the first trimester of a new pregnancy.

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“…Recent work has considered whether women who have had recurrent miscarriage have IR [7,8,9]. However, only FG has been examined.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Recurrent Miscarriage and Insulin Resistance

Wang¹,

Zhao²,

Li³

et al. 2011

Gynecol Obstet Invest

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“…In animal models of pharmacologically induced PCOS (rats with dihydrotestosterone-induced PCOS) real-time reverse-transcriptase PCR detected that the level of leptin expression in visceral fat of rats with PCOS was higher than that of controls (26). Several reports show that women with PCOS have higher circulating concentrations of leptin as compared with controls (27,28). The role of hyperleptinemia in women with PCOS is not clear yet, but there is a possibility that women with PCOS are leptin resistant.…”

Section: Discussionmentioning

confidence: 99%

Prediction of metabolic syndrome in women with polycystic ovary syndrome

Ersan¹,

Arslan²,

Esmer³

et al. 2012

J Turkish German Gynecol Assoc

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Objective: To identify biochemical factors that serve as predictors for the metabolic syndrome (MetS) in patients with polycystic ovary syndrome (PCOS) and to investigate the value of adipocytokines in the prediction of metabolic syndrome. Material and Methods:A total of 91 pre-menopausal women with PCOS diagnosed according to the Rotterdam consensus criteria were recruited as study subjects. Waist circumference, blood pressure, body mass index (BMI), fasting glucose, serum lipids, insulin, FSH, LH, E 2 , total testosteron, homeostatic model assessment-insulin resistance (HOMA-IR), serum leptin and adiponectin levels were evaluated for all patients. Results:Of the 91 women with PCOS, 15 patients met the criteria for MetS. Body weight, BMI, waist circumference, systolic blood pressure, diastolic blood pressure, fasting glucose, total cholesterol, triglyceride, and VLDL concentrations were significantly higher and HDL was significantly lower in women with PCOS+MetS compared with those with PCOS only. However, the level of LDL, FSH, LH, E 2 and total testesterone was not significantly different between these two groups. Women with PCOS+MetS had significantly higher levels of leptin and HOMA-IR, and significantly lower levels of adiponectin compared to the women with PCOS only. In the multiple logistic regression model, the association between HOMA-IR and leptin, and MetS remained statistically significant (p=0.001 and 0.018), while the association between adiponectin and MetS was no longer statistically significant. Conclusion: Abstract ÖzetOriginal Investigation 178

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“…Fertile women with PCOS have lower concentrations of serum and follicular fluid leptin than infertile women with PCOS, adjusted for age and BMI (Mantzoros et al 2000, Li et al 2007. High concentrations of leptin in serum and follicular fluid were associated with downregulation of STAT3 phosphorylation in granulosa cells despite no change in leptin receptor or SCOS3 expression, and this may contribute to infertility in PCOS (Li et al 2007).…”

Section: Polycystic Ovarian Syndromementioning

confidence: 96%

“…Women with PCOS are also found to have lower rates of fertilization, implantation, and pregnancy per in vitro fertilization cycle, compared with infertile women with tubal blockage (Li et al 2007). Fertile women with PCOS have lower concentrations of serum and follicular fluid leptin than infertile women with PCOS, adjusted for age and BMI (Mantzoros et al 2000, Li et al 2007.…”

Section: Polycystic Ovarian Syndromementioning

confidence: 97%

20 YEARS OF LEPTIN: Role of leptin in human reproductive disorders

Chou¹,

Mantzoros²

2014

Journal of Endocrinology

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Leptin, as a key hormone in energy homeostasis, regulates neuroendocrine function, including reproduction. It has a permissive role in the initiation of puberty and maintenance of the hypothalamic-pituitary-gonadal axis. This is notable in patients with either congenital or acquired leptin deficiency from a state of chronic energy insufficiency. Hypothalamic amenorrhea is the best-studied, with clinical trials confirming a causative role of leptin in hypogonadotropic hypogonadism. Implications of leptin deficiency have also emerged in the pathophysiology of hypogonadism in type 1 diabetes. At the other end of the spectrum, hyperleptinemia may play a role in hypogonadism associated with obesity, polycystic ovarian syndrome, and type 2 diabetes. In these conditions of energy excess, mechanisms of reproductive dysfunction include central leptin resistance as well as direct effects at the gonadal level. Thus, reproductive dysfunction due to energy imbalance at both ends can be linked to leptin.

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Association of Serum and Follicular Fluid Leptin Concentrations with Granulosa Cell Phosphorylated Signal Transducer and Activator of Transcription 3 Expression in Fertile Patients with Polycystic Ovarian Syndrome

Cited by 36 publications

References 31 publications

Relationship between Recurrent Miscarriage and Insulin Resistance

Relationship between Recurrent Miscarriage and Insulin Resistance

Prediction of metabolic syndrome in women with polycystic ovary syndrome

20 YEARS OF LEPTIN: Role of leptin in human reproductive disorders

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