Association of serum biomarkers with early neurologic improvement after intravenous thrombolysis in ischemic stroke

Abstract

Background Early neurologic improvement (ENI) after intravenous thrombolysis is associated with favorable outcome, but associated serum biomarkers were not fully determined. We aimed to investigate the issue based on a prospective cohort. Methods In INTRECIS study, five centers were designed to consecutively collect blood sample from enrolled patients. The patients with ENI and without ENI were matched by propensity score matching with a ratio of 1:1. Preset 49 biomarkers were measured through microarray analysis. Enrichment of gene ontology and pathway, and protein-protein interaction network were analyzed in the identified biomarkers. Results Of 358 patients, 19 patients with ENI were assigned to ENI group, while 19 matched patients without ENI were assigned to Non ENI group. A total of nine biomarkers were found different between two groups, in which serum levels of chemokine (C-C motif) ligand (CCL)-23, chemokine (C-X-C motif) ligand (CXCL)-12, insulin-like growth factor binding protein (IGFBP)-6, interleukin (IL)-5, lymphatic vessel endothelial hyaluronan receptor (LYVE)-1, plasminogen activator inhibitor (PAI)-1, platelet-derived growth factor (PDGF)-AA, suppression of tumorigenicity (ST)-2, and tumor necrosis factor (TNF)-α were higher in the ENI group, compared with those in the Non ENI group. Conclusions We found that serum levels of CCL-23, CXCL-12, IGFBP-6, IL-5, LYVE-1, PAI-1, PDGF-AA, ST-2, and TNF-α at admission were associated with post-thrombolytic ENI in stroke. The role of biomarkers warrants further investigation. Trial registration Clinical Trial Registration: https://www.clinicaltrials.gov; identifier: NCT02854592.

Effects of glycemic indicators on early neurological outcomes in patients with acute ischemic stroke treated with intravenous thrombolysis

“…Based on the results of the present study, the clinical symptoms were improved in 156 patients (19.0%), unchanged in 455 patients (55.6%)and deteriorated in 208 patients (25.4%) during the rst 24 h after IVT. Our results were consistent with previous studies showing signi cant individual differences in the effects of IVT therapy [9,29,30].…”

“…However, individual differences in the early neurological outcomes after IVT therapy are signi cant. While some have shown signi cant neurological improvement after IVT therapy, others have derived fewer bene ts, and may even suffer neurological deterioration [7][8][9][10]. Early neurological outcomes (ENO) after IVT, including early neurological improvement (ENI) and early neurological deterioration (END).…”

Role of MRI in Diagnosis and Management of Stroke Cases; A Systematic Review

“…The search strategy results were examined for duplicate features using Rayyan (QCRI) [9]. The researchers evaluated the pooled search results against a list of inclusion/exclusion criteria to determine the suitability of the titles and abstracts.…”

“…Many attempts have been undertaken over the last few decades to enhance the result of acute ischemic stroke therapy. But within 3 or 4.5 hours of the onset of symptoms, the only validated treatment for people with an acute ischemic stroke is thrombolytic therapy [9].…”