Association of serum concentrations of persistent organic pollutants (POPs) and risk of pre-eclampsia: a case–control study

Eslami, Bita; Malekafzali, Hossein; Rastkari, Noushin; Rashidi, Batool Hossein; Djazayery, A; Naddafi, Kazem

doi:10.1186/s40201-016-0256-9

Cited by 24 publications

(17 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hypertension has been shown to associate with PCB 57,58 , but very few studies have looked for associations with PBB or hypertensive disorders of pregnancy (gestational hypertension, pre-eclampsia, and eclampsia). A small Iranian study (N = 45) showed an increased risk with PCB and pre-eclampsia 34 while our study and a larger cohort study did not find any increased risks of developing any hypertensive disorders of pregnancy 35 .…”

Section: Discussioncontrasting

confidence: 75%

Examining Reproductive Health Outcomes in Females Exposed to Polychlorinated Biphenyl and Polybrominated Biphenyl

Neblett

Curtis

Gerkowicz

et al. 2020

Sci Rep

View full text Add to dashboard Cite

In 1973, accidental contamination of Michigan livestock with polybrominated biphenyls (PBBs) led to the establishment of a registry of exposed individuals that have been followed for > 40 years. Besides being exposed to PBBs, this cohort has also been exposed to polychlorinated biphenyls (PCBs), a structurally similar class of environmental pollutants, at levels similar to average US exposure. In this study, we examined the association between current serum PCB and PBB levels and various female reproductive health outcomes to build upon previous work and inconsistencies. participation in this cross-sectional study required a blood draw and completion of a detailed health questionnaire. Analysis included only female participants who had participated between 2012 and 2015 (N = 254). Multivariate linear and logistic regression models were used to identify associations between serum PCB and PBB levels with each gynecological and infertility outcome. Additionally, a generalized estimating equation (GEE) model was used to evaluate each pregnancy and birth outcome in order to account for multiple pregnancies per woman. We controlled for age, body mass index, and total lipid levels in all analyses. A p-value of <0.05 was used for statistical significance. Among the women who reported ever being pregnant, there was a significant negative association with higher total PCB levels associating with fewer lifetime pregnancies (β = −0.11, 95% CI = −0.21 to −0.005, p = 0.04). There were no correlations between serum PCB levels and the self-reported gynecological outcomes (pelvic inflammatory disease, endometriosis, polycystic ovarian syndrome, or uterine fibroids). No associations were identified between serum PCB levels and the prevalence of female infertility in women reporting ever having sexual intercourse with a male partner. There were no associations identified between serum PCB levels and pregnancy outcomes (singleton live births or miscarriages) or birth outcomes (preterm birth, birth weight, birth defects, hypertensive disorders of pregnancy, or gestational diabetes). PBB was not associated with any outcome. Further research is needed to determine if and how PCB may reduce pregnancy number. Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs) are synthetic chemicals that were once used as coolants in electrical equipment and as flame retardants in the manufacturing of plastics and electronics, respectively 1,2. Although the production of PCBs ceased in 1977 and PBBs in 1976, concern over their health effects remains because of their continued persistence in the environment, the pervasiveness of their exposure in

show abstract

Section: Discussioncontrasting

confidence: 75%

Examining Reproductive Health Outcomes in Females Exposed to Polychlorinated Biphenyl and Polybrominated Biphenyl

Neblett

Curtis

Gerkowicz

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Preeclampsia cases were ascertained by two specialist physicians who considered women preeclamptic if they met ACOG’s criterion for hypertension and exhibited any degree of proteinuria. In models controlling for gestational age, pre-pregnancy BMI, and weight gain, Eslami et al (2016) measured OR of 1.77 (95% CI: 1.34, 2.32) for total PCB and OR of 2.19 (95% CI: 1.39, 3.45) for total PBDE, but the investigators did not account for the contrast associated with these results. In this population, the median level of total PCB for cases was 2.86 ng/g and 1.50 ng/g for controls; the median level for total PBDE was 1.51 ng/g among cases and 0.95 ng/g among controls (Eslami et al 2016).…”

Section: Resultsmentioning

confidence: 96%

“…Briefly, the 28 investigations were published between 2006–2018 with sample sizes ranging from 58 to 1.21 million women. There were 6 studies on POP (Eslami et al 2016; Murray et al 2018; Savitz et al 2012; 2014; Stein et al 2009; Starling et al 2014), one study on water contaminants (Carwile et al 2014), 11 investigations on air pollutants (Dadvand et al 2014; Lee et al 2013; Madsen et al 2017; Mendola et al 2016; Nahidi et al 2014; Pedersen et al 2017; Savitz et al 2015; Wang et al 2018b; Wesselink et al 2017; Wu et al 2016; Yorifuji et al 2015), 6 examining metals (Elongi Moyene et al 2016; Maduray et al 2017; Sandoval-Carrillo et al 2016; Laine et al 2015; Wang et al 2018a; Vigeh et al 2006), and 4 investigations evaluating non-persistent organic pollutants (Cantonwine et al 2016; Leclerc et al 2014; Ye et al 2017; Shaw et al 2018).…”

Section: Resultsmentioning

confidence: 99%

“…Only one study to date examined the association between PBDE exposure and preeclampsia. In a case-control study by Eslami et al (2016), Iranian women diagnosed with preeclampsia displayed higher serum concentrations of total PCB and total PBDE compared to controls (Table 1). Preeclampsia cases were ascertained by two specialist physicians who considered women preeclamptic if they met ACOG’s criterion for hypertension and exhibited any degree of proteinuria.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Environmental contaminants and preeclampsia: a systematic literature review

Rosen

Muñoz

McElrath

et al. 2018

Journal of Toxicology and Environmental Health, Part B

View full text Add to dashboard Cite

Preeclampsia is a medical condition specific to pregnancy characterized by high blood pressure and protein in the woman’s urine, indicating kidney damage. It is one of the most serious reproductive conditions, posing substantial risks to the baby and potentially fatal for the mother. The causes of preeclampsia are largely unknown and environmental contaminants merit further investigation. The aim of this review was to determine the association between environmental chemical exposures and preeclampsia.PubMed was searched for articles examining a priori chemical exposures and preeclampsia through April 2018. Studies were included in our review if they included at least 10 cases, evaluated preeclampsia independent of gestational hypertension, and used either measured or modeled exposure assessments.Our review contained 28 investigations examining persistent organic pollutants (POP) (6 studies), drinking water contaminants (1 study), atmospheric pollutants (11 studies), metals and metalloids (6 studies), and other environmental contaminants (4 studies). There were an insufficient number of investigations on most chemicals to draw definitive conclusions, but strong evidence existed for an association between preeclampsia and cadmium (Cd). There is suggestive evidence for associations between nitrogen dioxide (NO2), particulate matter (PM)2.5, and traffic exposure with preeclampsia.There is evidence for an association between preeclampsia and Cd but insufficient literature to evaluate many other environmental chemicals. Additional studies using repeated measures, appropriate biological matrices, and mixtures methods are needed to expand this area of research and address the limitations of previous studies.

show abstract

“…In humans, the relationship between PBDE exposures and pregnancy complications (e.g., preeclampsia) remains undefined. Eslami et al (2016) found a significant association between total PBDEs and preeclampsia among first mothers in Iran, while no association was detected in a prospective U.S. cohort [29,30]. In mice and/or human cell lines, PBDEs alter hormone production [31], elicit inflammation [32][33][34], and promote oxidative stress [32,[35][36][37][38][39].…”

Section: Introductionmentioning

confidence: 96%

Association of polybrominated diphenyl ether (PBDE) levels with biomarkers of placental development and disease during mid-gestation

et al. 2020

View full text Add to dashboard Cite

Background: Polybrominated diphenyl ether (PBDE) exposures have been associated with adverse pregnancy outcomes. A hypothesized mechanism is via alterations in placental development and function. However, we lack biomarkers that can be used as early indicators of maternal/fetal response to PBDE exposures and/or perturbations in placental development or function. Methods: To evaluate the relationship between PBDE levels and placental biomarkers during mid-gestation of human pregnancy (n = 62), we immunolocalized three molecules that play key roles in cytotrophoblast (CTB) differentiation and interstitial/endovascular uterine invasion-integrin alpha-1 (ITGA1), vascular endothelial-cadherin (CDH5), and metalloproteinase-1 (MMP1)-and assessed three morphological parameters as potential indicators of pathological alterations using H&E-stained tissues-leukocyte infiltration, fibrinoid deposition, and CTB endovascular invasion. We evaluated associations between placental PBDE levels and of biomarkers of placental development and disease using censored Kendall's tau correlation and linear regression methods. Results: PBDEs were detected in all placental samples. We observed substantial variation in antigen expression and morphological endpoints across placental regions. We observed an association between PBDE concentrations and immunoreactivity of endovascular CTB staining with anti-ITGA1 (inverse) or interstitial CTBs staining with anti-CDH5 (positive).

show abstract

Association of serum concentrations of persistent organic pollutants (POPs) and risk of pre-eclampsia: a case–control study

Cited by 24 publications

References 44 publications

Examining Reproductive Health Outcomes in Females Exposed to Polychlorinated Biphenyl and Polybrominated Biphenyl

Examining Reproductive Health Outcomes in Females Exposed to Polychlorinated Biphenyl and Polybrominated Biphenyl

Environmental contaminants and preeclampsia: a systematic literature review

Association of polybrominated diphenyl ether (PBDE) levels with biomarkers of placental development and disease during mid-gestation

Contact Info

Product

Resources

About