Association of serum creatinine with aortic arch calcification in middle-aged and elderly adults: an observational cross-sectional study from China

Abstract

Background and aims Vascular calcification (VC) is a strong predictor of cardiovascular events and all-cause mortality in cardiovascular diseases (CVD). Renal dysfunction is closely related to VC. Serum creatinine, as an important indicator of renal function in chronic kidney disease (CKD), is closely associated with increased VC. Here, to explore the potential role of serum creatinine in CVD, we examined the association between serum creatinine level and aortic arch calcification (AAC) presence in a larger general population. Methods A total of 9067 participants aged > 45 years were included in this study. All participants underwent postero-anterior chest X-ray examination to diagnose AAC. According to the distribution characteristics, serum creatinine levels in male and female were divided into tertiles respectively. Univariate and multivariate logistic regression analysis were used to analyze the association between aortic calcification and serum creatinine. Results Participants included 3776 men and 5291 women, and 611 and 990 AAC were detected, respectively. Serum creatinine level in the female AAC group was significantly higher than that in the non-AAC group (p < 0.001), while there was no significant difference in male serum creatinine between the two groups (p = 0.241). After logistic regression analysis excluded confounding factors, with the first tertile of serum creatinine as the reference, multivariable-adjusted ORs and 95% CIs of the second and the highest tertile of female and male were 1.045 (0.856–1.276), 1.263 (1.036–1.539); 0.953 (0.761–1.193), 0.948 (0.741–1.198), respectively. Conclusion Elevated serum creatinine levels are independently associated with higher AAC incidence in female aged > 45 years old. Measuring serum creatinine levels may assist the early screening individuals at high risk of developing CVD. And higher attention should be given to female's serum creatinine levels in daily clinical practice.

Joint modeling on serum creatinine and time to end stage of renal disease for chronic kidney disease patients under treatment at the University of Gondar Referral Hospital

“…In this research, there was an association between sex and SCr values indicating that males develop CKD more than females so sex is the most significant factor for CKD. This study was in line with the result of the study conducted by Zhang et al 7 , 12 and Maraghi et al, 11 may be a result of men living unhealthier lives, the protective benefits of estrogens, or the harmful effects of testosterone. It could result from an imbalance of sex hormones.…”

“…It could result from an imbalance of sex hormones. The average SCr of CKD patients who had hypertension, chronic heart disease, and diabetes mellitus was increased this finding was lined with the study done by Zhang et al 12 The average SCr of CKD patients who had diabetes mellitus was significantly higher as compared with none diabetic patients this finding was lined with the study done by Bash et al 13 This implies that patients with diabetes are more likely to acquire ESRD. The damage caused by vessel microangiopathy is the key problem associated with the rise in cardiovascular events.…”

The context-dependent role of transforming growth factor-β/miR-378a-3p/connective tissue growth factor in vascular calcification: a translational study

“…Older adults carry an exquisitely high burden of VC. Previous studies reported that 16.6% of middle-age to older adults had aortic arch calcification [ 26 ], while another discovered that nearly 50% of older adults from a population-based study had incident coronary artery calcification, 2-fold higher than that in younger ones [ 27 ]. Risk factors for having VC in older adults include specific gender, greater adiposity or less lean mass, and osteoporosis [ 28 , 29 ].…”

Sarcopenia is Associated with Aortic Arch Calcification on Chest X-ray in Unselected Middle- and Older-Aged Patients

“…Within daily clinical practice, aortic arch calci cation (AAC) can be easily detected using a simple chest X-ray [11]. AAC is related to aging, diabetes mellitus (DM), chronic kidney disease (CKD), and osteoporosis [12][13][14]. It is also closely associated with sarcopenia [1,[15][16][17].…”