Association of serum ferritin levels with non-alcoholic fatty liver disease in postmenopausal women

Kim, H.-B.; Lee, H.-S.; Lee, Y.-J.

doi:10.1080/13697137.2018.1493451

Cited by 9 publications

(6 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Liver biopsies of 222 patients (men and women) with NAFLD showed that serum ferritin levels, which are biomarkers of iron metabolism, are positively associated with a higher NAFLD activity score [316]. The relation between ferritin level and NAFLD is mostly significant in men and associated with hepatic iron deposition, fibrosis, and NASH [77,317]. A correlation between ferritin level and NAFLD development also has been observed in a cohort of postmenopausal women [317].…”

Section: Dietary Oxidants In Nafldmentioning

confidence: 90%

See 1 more Smart Citation

Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants

et al. 2020

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) is often the hepatic expression of metabolic syndrome and its comorbidities that comprise, among others, obesity and insulin-resistance. NAFLD involves a large spectrum of clinical conditions. These range from steatosis, a benign liver disorder characterized by the accumulation of fat in hepatocytes, to non-alcoholic steatohepatitis (NASH), which is characterized by inflammation, hepatocyte damage, and liver fibrosis. NASH can further progress to cirrhosis and hepatocellular carcinoma. The etiology of NAFLD involves both genetic and environmental factors, including an unhealthy lifestyle. Of note, unhealthy eating is clearly associated with NAFLD development and progression to NASH. Both macronutrients (sugars, lipids, proteins) and micronutrients (vitamins, phytoingredients, antioxidants) affect NAFLD pathogenesis. Furthermore, some evidence indicates disruption of metabolic homeostasis by food contaminants, some of which are risk factor candidates in NAFLD. At the molecular level, several models have been proposed for the pathogenesis of NAFLD. Most importantly, oxidative stress and mitochondrial damage have been reported to be causative in NAFLD initiation and progression. The aim of this review is to provide an overview of the contribution of nutrients and food contaminants, especially pesticides, to oxidative stress and how they may influence NAFLD pathogenesis.

show abstract

Section: Dietary Oxidants In Nafldmentioning

confidence: 90%

“…The relation between ferritin level and NAFLD is mostly significant in men and associated with hepatic iron deposition, fibrosis, and NASH [77,317]. A correlation between ferritin level and NAFLD development also has been observed in a cohort of postmenopausal women [317].…”

Section: Dietary Oxidants In Nafldmentioning

confidence: 93%

Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The prevalence of NAFLD was up to 30% in the general population and 26.3% in men [3–5]. In postmenopausal women, the prevalence of NAFLD was up to approximately 40%, which suggested a greater importance of NAFLD for postmenopausal women [6]. The development of NAFLD is also closely correlated with several chronic diseases, such as obesity, type 2 diabetes mellitus, dyslipidemia, and hypertension, which are components of metabolic syndrome (MetS) [7–9].…”

Section: Introductionmentioning

confidence: 99%

Association between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease according to Different Menstrual Status Groups

Chen

Huang

et al. 2019

Canadian Journal of Gastroenterology and Hepatology

View full text Add to dashboard Cite

Objective The present study aimed to explore the association between SUA and NAFLD in women with different menstrual statuses. Methods A total of 6043 women were selected from the Jidong and Kailuan communities for inclusion in the present study. The SUA levels of participants were divided into quartiles. NAFLD was determined by abdominal ultrasonography. Data from laboratory tests and clinical examination were collected, and basic information was obtained from standardized questionnaires. The menstrual status was stratified into menstrual period, menopause transition period, and postmenopause. Multivariate logistic regression models were used to determine the relationship between menstrual status, SUA, and NAFLD. Results The levels of SUA in subjects with NAFLD in the menstrual period, menopause transition period, and postmenopause were 268.0 ± 71.1, 265.6 ± 67.8, and 286.7 ± 75.8 (mmol/L), respectively, and were higher than those in subjects without NAFLD. The adjusted odds ratios (ORs) with 95% confidence interval (CI) for NAFLD among participants in the menopause transition period and postmenopausal period were 1.10 (0.89–1.37) and 1.28 (1.04–1.58), respectively, compared with the menstrual period women. Compared to the lowest quartile of SUA, the adjusted ORs with 95% CI of the highest quartile for NAFLD were 2.24 (1.69–2.99) for females in the menstrual period, 1.92 (1.10–3.37) for females in the menopause transition period, and 1.47 (1.06–2.03) for females in postmenopause. Conclusions Menstrual status was significantly correlated with NAFLD. High levels of SUA were associated with NAFLD in females during the three menstrual periods.

show abstract

“…Two cross-sectional studies also showed that higher serum ferritin was associated with a higher risk of NAFLD and elevated ALT among Chinese adults with normal weight [25,26]. In addition, a Korean study conducted on postmenopausal women found that the serum ferritin level was positively and independently associated with NAFLD [27]. Most cross-sectional studies reported a positive association between serum ferritin levels and the prevalence of NAFLD, however, cross-sectional study designs cannot be used to determine causal relationships because temporality is not known.…”

Section: Discussionmentioning

confidence: 99%

“…Several cross-sectional and case-control studies have assessed the association between serum ferritin levels and the risk of NAFLD [24][25][26][27]. Recent a cross-sectional study found that serum ferritin positively associated with alanine aminotransferase (ALT) among subjects with overweight/obesity and ultrasound-con rmed liver steatosis [24].…”

Section: Discussionmentioning

confidence: 99%

Serum ferritin as an independent predictor of non-alcohol fatty liver disease in general adults: the TCLSIH cohort study

Meng

Chen

et al. 2022

Preprint

View full text Add to dashboard Cite

Background Serum ferritin is an important iron storage protein in the human body, which indicates iron storage and the body’s nutritional status, and is associated with a variety of chronic diseases. Few prospective studies have assessed the association between serum ferritin levels and non-alcoholic fatty liver disease (NAFLD). This prospective cohort study aimed to explore whether serum ferritin levels were associated with the incidence of NAFLD in a large-scale adult population. Methods A total of 15,748 participants without baseline NAFLD were enrolled in the cohort study (1-9 years follow-up periods, median: 4.5 years). Serum ferritin levels were determined by protein chip-chemiluminescence method, and NAFLD was diagnosed by abdominal ultrasonography. Multivariable Cox proportional hazards regression models were used to assess the association between baseline serum ferritin levels and the risk of NAFLD. Results During the follow-up period, 3,374 new NAFLD cases were observed, and the incidence rate of NAFLD was 83.4 per 1000 person-years. In the fully adjusted model, the hazards ratios (95% confidence interval) for incident NAFLD across serum ferritin levels quartiles were 1.06 (0.94-1.19), 1.25 (1.11-1.41), and 1.52 (1.28-1.79) (P for trend <0.0001). Receiver operating characteristic (ROC) analysis showed that the optimal cut-off values were 55.9 mg/dl for serum ferritin levels (Area under the ROC curve (AUC)=0.61) Conclusion Increased serum ferritin level was independently associated with a higher risk of incident NAFLD in a large-scale general population. It is suggested that serum ferritin levels can be useful for the early detection of subjects at high risk of developing NAFLD.

show abstract

Association of serum ferritin levels with non-alcoholic fatty liver disease in postmenopausal women

Abstract: The serum ferritin level was positively and independently associated with NAFLD in postmenopausal women and could be a useful additional measure in assessing the risk of NAFLD in postmenopausal women.

Cited by 9 publications

References 35 publications

Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants

Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants

Association between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease according to Different Menstrual Status Groups

Serum ferritin as an independent predictor of non-alcohol fatty liver disease in general adults: the TCLSIH cohort study

Contact Info

Product

Resources

About