Association of Serum Fetuin-A With Insulin Resistance in Type 2 Diabetic and Nondiabetic Subjects

Mori, Katsuhito; Emoto, Masanori; Yokoyama, Hisayo; Araki, Tsuyoshi; Teramura, Megumi; Koyama, Hidenori; Shoji, Tetsuo; Inaba, Masaaki; Nishizawà, Yoshiki

doi:10.2337/diacare.29.02.06.dc05-1484

Cited by 196 publications

(169 citation statements)

References 3 publications

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“…In our study, the total Mg concentration was significantly decreased in the patients with T2DM (Table 3). This result is also consistent with that described in a previous study, which revealed a connection between T2DM and Mg deficiency (23). Low serum Mg is a strong independent predisposing factor of IR and T2DM development (39).…”

Section: Original Articleesupporting

confidence: 82%

“…Our study demonstrated that serum fetuin-A was related to IR, and HOMA2IR index and fasting insulin serum levels were increased; this result is consistent with previous results (4,(22)(23)(24). Therefore, fetuin-A may be used as a new factor implicated in T2DM pathology and physiology; IR also plays an important role in the T2DM mechanism (25).…”

Section: Original Articleesupporting

confidence: 81%

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Association of Insulin Resistance, β-Cell Function Impairment and Calcium, Magnesium, and Fetuin-A Concentrations in Women with Type 2 Diabetes Mellitus

Moustafa¹

2016

Acta Facultatis Medicae Naissensis

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SU M M A RYInsulin resistance and β-cell function impairment play a role in the pathogenesis of type 2 diabetes (T2DM). Insulin signaling is inhibited by fetuin-A, an abundant plasma protein. Fetuin-A is also a candidate marker of the T2DM risk. This case-control study aimed to determine whether fetuin-A serum level is related to insulin resistance, β-cell function impairment, and total and ionized Ca and Mg serum levels in Erbil patients with T2DM.A total of 60 patients with T2DM were recruited, and 30 healthy persons were included in the control group. Fetuin-A and insulin concentrations were measured through ELISA. Other biochemical parameters were determined spectrophotometrically. Insulin resistance (HOMA2IR), insulin sensitivity (HOMA2%S), and β-cell function were examined by using a homeostatic model assessment 2 (HOMA2).Fasting serum insulin, fetuin-A serum levels, and HOMA2IR were significantly increased. HOMA2%S of the patients with diabetes was significantly lower than that of the control group. The total serum and ionized Ca and Mg contents and the Ca/Mg ratio were reduced in the patients.Therefore, fetuin-A is related to T2DM pathogenesis and is strongly associated with insulin resistance and glycemic control in T2DM patients. Future large-scale studies are necessary to validate fetuin-A as an indicator of IR in T2DM patients.

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Section: Original Articleesupporting

confidence: 82%

Section: Original Articleesupporting

confidence: 81%

Association of Insulin Resistance, β-Cell Function Impairment and Calcium, Magnesium, and Fetuin-A Concentrations in Women with Type 2 Diabetes Mellitus

Moustafa¹

2016

Acta Facultatis Medicae Naissensis

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“…The circulating levels of fetuin A show negative correlation to the insulin sensitivity [22,23]. Its serum concentrations in humans are positively correlated to CRP levels, that are a marker of subclinical chronic inflammation [24,25].…”

Section: Introductionmentioning

confidence: 99%

MCP-1 and fetuin A levels in patients with PCOS and/or obesity before and after metformin treatment

2013

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“…The reason we studied liver-derived fetuin-A in women with PCOS and compare with non PCOS women was the previous observation that this protein may play a significant role in mechanisms at insulin sensitivity, weight gain and fat accumulation (8,16) . Especially because, as in animal and human studies the inhibitory function of fetuin-A on insulin receptor (tyrosine kinase) in the muscle and in the liver has been proved (17,6) .…”

Section: Discussion:-mentioning

confidence: 99%

“…Its circulating levels show negative correlation to the insulin. AHSG is thought to play a significant role in weight gain, fat accumulation and the development of type 2 diabetes ( 7,8) .…”

Section: Introduction:-mentioning

confidence: 99%

The Effect of Different Ovarian Stimulation Protocols on Multifunctional Fetuin_a Concentration in the Serum and Follicular Fluid of Women With Pcos Undergoing Icsi/Ivf.

Aboudy¹,

ALAni²,

AlKawaz³

2017

IJAR

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Objective:To measure the concentration of fetuin-A in serum and follicular fluid of patients with PCOS at day of ova pick up after using of different IVF/ICSI protocols and to assess the pregnancy outcome. Study design: A total of 90 infertile women (55 women with Polycystic ovary syndrome and the other 35 women as a control (non PCOS) undergoing controlled ovarian hyperstimulation for intracytoplasmic sperm injection cycle were prospectively recruited for this study in High Institute of Infertility Diagnosis and Assisted Reproductive Technology / AL-Nahrian University and Kamal ALSamarai Hospital, center of fertility and IVF (Baghdad/Iraq) during the period from December 2015 to the end of April 2017.The fifty five PCOS women were divided into three groups: twenty five (25) infertile women have had PCOS undergoing long Agonist protocol for ICSI cycle, fifteen (15) infertile women have had PCOS undergoing Antagonist protocol for ICSI and fifteen (15) infertile women have had PCOS undergoing short Agonist protocol for ICSI. The controlled group included 35 women were free of signs and symptoms of PCOS with regular cycles and no endocrine abnormalities undergoing ICSI cycle (15 infertile women underwent long agonist protocol, 10 women underwent short agonist and 10 women underwent antagonist protocol). In all patients, serum and follicular fluid fetuin-A levels were measured on the day of oocyte retrieval by using Enzyme linked immuno sorbent assay. Results: There was significant difference (p<0.05) in the level of fetuin-A in follicular fluid between PCOS and control group. Follicular fluid fetuin-A level was high in non PCOS patients than PCOS patients but no significant difference (p>0.05) in the level of fetuin-A in serum between PCOS and control group. Also there was no significant difference in the effect of different IVF/ICSI protocols (Long agonist, Antagonist, Short agonist) in the level of follicular & serum fetuin-A of patients with PCOS (P>0.05) and no significant difference (P>0.05) in level of serum and follicular fluid fetuin-A between pregnant &non pregnant PCOS patients. ž Conclusion: It was concluded from the present study that FF fetuin-A concentration of PCOS patients at the day of oocyte retrieval is significantly lower than that of non PCOS patient. But no significant

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Association of Serum Fetuin-A With Insulin Resistance in Type 2 Diabetic and Nondiabetic Subjects

Cited by 196 publications

References 3 publications

Association of Insulin Resistance, β-Cell Function Impairment and Calcium, Magnesium, and Fetuin-A Concentrations in Women with Type 2 Diabetes Mellitus

Association of Insulin Resistance, β-Cell Function Impairment and Calcium, Magnesium, and Fetuin-A Concentrations in Women with Type 2 Diabetes Mellitus

MCP-1 and fetuin A levels in patients with PCOS and/or obesity before and after metformin treatment

The Effect of Different Ovarian Stimulation Protocols on Multifunctional Fetuin_a Concentration in the Serum and Follicular Fluid of Women With Pcos Undergoing Icsi/Ivf.

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