Association of serum hs-CRP and lipids with obesity in school children in a 12-month follow-up study in Japan

Nishide, Ritsuko; Ando, Michiko; Funabashi, Hidemitsu; Yoda, Yoshiko; Shima, Masayuki

doi:10.1007/s12199-014-0433-3

Cited by 28 publications

(22 citation statements)

References 33 publications

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“…The association of serum hs-CRP with excessive weight and abdominal obesity is consistent with previous studies performed with children and adolescents classified as overweight and obese by the BMI or body fat percentage [4, 5, 13, 16, 37], as well as in children with increased waist circumference [13–15, 38]. This association suggests that, although there are no cutoff points of hs-CRP for infant population, obesity-related subclinical inflammation is already observed in early ages.…”

Section: Discussionsupporting

confidence: 91%

Increased C-Reactive Protein in Brazilian Children: Association with Cardiometabolic Risk and Metabolic Syndrome Components (PASE Study)

Suhett

Hermsdorff

Rocha

et al. 2019

Cardiology Research and Practice

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C-reactive protein (CRP) is a marker of subclinical inflammation that has been found to be associated with cardiovascular disease risk. However, few studies have investigated the relationship between CRP and cardiometabolic markers in a representative sample of prepubescent children. The objective was to evaluate the high-sensitive CRP (hs-CRP) and its association with traditional and nontraditional cardiometabolic risk factors, as well as metabolic syndrome (MetS) components in Brazilian children. This is a cross-sectional representative study, with participants of the Schoolchildren Health Assessment Survey (PASE). Children from 8 to 9 years old (n=350) enrolled in public and private schools in the municipality of Viçosa, Minas Gerais, Brazil, were evaluated. Sociodemographic evaluation was performed through a semistructured questionnaire. Anthropometric, body composition, clinical, and biochemical measures were analyzed for cardiometabolic risk assessment. The total mean of serum hs-CRP concentration was 0.62 (±1.44) mg/L. hs-CRP was significantly correlated with several anthropometric, biochemical, and clinical parameters in this population (P<0.05). hs-CRP was positively associated with the accumulation of cardiometabolic risk factors and MetS components (P<0.05). Children with excessive weight; abdominal obesity; increased gynoid and android body fat; low HDL-c; hyperglycemia; and elevated uric acid, homocysteine, and apoB had higher chances of presenting increased hs-CRP (P<0.05). In this study, Brazilian children with cardiometabolic risk already presented elevated serum hs-CRP concentration. hs-CRP was associated with the increase of traditional and nontraditional cardiometabolic risk factors, as well as the accumulation of MetS components.

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Section: Discussionsupporting

confidence: 91%

Increased C-Reactive Protein in Brazilian Children: Association with Cardiometabolic Risk and Metabolic Syndrome Components (PASE Study)

Suhett

Hermsdorff

Rocha

et al. 2019

Cardiology Research and Practice

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show abstract

“…Our study confirms that elevated serum hs-CRP is associated with abnormal lipid metabolism in adults. This connection was also confirmed in a given population in previous studies [38,39]. In Quebec, in children ages 9 years, 14 years, and 16 years, elevated CRP levels were found to be independently associated with worsening lipid status (high TG and low HDL-C concentrations).…”

Section: Discussionsupporting

confidence: 82%

Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels

Yan

Zhang

et al. 2020

Journal of Diabetes Research

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This study is aimed at exploring the relationship between serum ferritin and blood lipids and the influence of diabetes and different hs-CRP levels. A total of 8163 subjects were analyzed. Participators were classified according to serum ferritin, diabetes, and two hs-CRP levels. Blood lipids were determined using standardized methods and conditions. Except for HDL-C, there was a significant increase in blood lipids in the progressive ferritin group with normal hs-CRP levels (P<0.05). But HDL-C was just the opposite (P<0.0001). In nondiabetic patients, TG, TC, and LDL-C were significantly elevated in the progressive ferritin group (P<0.05). And, HDL-C was just the opposite (P<0.05). The generalized linear model and the parsimonious model showed that serum TG was positively correlated with ferritin, and LDL-C was negatively correlated with ferritin (P<0.05). But the correlation between LDL-C and ferritin was broken (P>0.05). After a sufficient adjustment, there was a positive correlation between serum TG and ferritin and a negative correlation between LDL-C and ferritin. Nonetheless, a negative correlation between LDL-C and ferritin is influenced by diabetes frailly. And, there was no change of relationship between lipids and ferritin in different hs-CRP levels. We found a real relationship between ferritin and lipids after sufficient adjustment for confounders.

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“…When excluding acute infections, CRP has been shown to be elevated in children with obesity (53), to be associated with hyperlipidemia (54) and to predict IR (55). Moreover, CRP levels predict obesity after 1-6 years of follow-up (53,56), providing a potential therapy goal in short-term treatment. Almost one-third of the participants in our study had elevated CRP levels, which is in line with other studies that report between 1.5 and 15 mg/l for participants with obesity (39,57,58).…”

Section: Discussionmentioning

confidence: 99%

A Multidisciplinary Intervention in Childhood Obesity Acutely Improves Insulin Resistance and Inflammatory Markers Independent From Body Composition

et al. 2020

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Childhood obesity is an increasing health care problem associated with insulin resistance and low-level systemic inflammation, which can ultimately lead to diabetes. Evidence for efficacy of therapeutic intervention programs on the early development of obesity associated sequelae is moderate. This paper investigates the effect of a multidisciplinary short-term intervention program on insulin resistance and metaflammation in childhood obesity. Two hundred and 36 overweight or obese children and adolescents between the ages of 10 and 14 were included in a prospective 5 months intervention study, which included sports, psychotherapy, and nutritional counseling. Primary endpoints were the effects on body mass index standard deviation score (BMI-SDS) and homeostatic model assessment of insulin resistance (HOMA-IR), key secondary endpoints were the levels of C-reactive protein (CRP), leptin, and adiponectin. At baseline, a substantial proportion of participants showed signs of insulin resistance (mean HOMA-IR 5.5 ± 3.4) despite not meeting the diagnostic criteria for diabetes, and low-level inflammation (mean CRP 3.9 mg/l ± 3.8 mg/l). One hundred and 95 participants (83%) completed the program resulting in a significant reduction in BMI-SDS, HOMA-IR, CRP, and leptin and a significant increase in adiponectin (mean change compared to baseline −0.14, −0.85, −1.0 mg/l, −2.8 ng/ml, and 0.5 µg/ml, respectively; p < 0.001 each). Effects on BMI-SDS, HOMA-IR, CRP, and adiponectin were largely independent whereas leptin was positively correlated with BMI-SDS and total fat mass before and after intervention (r = 0.56 and 0.61, p < 0.001 each). Short-term multidisciplinary intervention successfully Mayerhofer et al. Insulin Resistance in Childhood Obesity improved body composition, insulin sensitivity, low-level systemic inflammation, and the adipokine profile in childhood obesity. Our findings highlight the immediate connection between obesity and the pathophysiology of its sequelae, and emphasize the importance of early intervention. Continued lifestyle modification is likely necessary to consolidate and augment the long-term effects.

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Association of serum hs-CRP and lipids with obesity in school children in a 12-month follow-up study in Japan

Cited by 28 publications

References 33 publications

Increased C-Reactive Protein in Brazilian Children: Association with Cardiometabolic Risk and Metabolic Syndrome Components (PASE Study)

Increased C-Reactive Protein in Brazilian Children: Association with Cardiometabolic Risk and Metabolic Syndrome Components (PASE Study)

Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels

A Multidisciplinary Intervention in Childhood Obesity Acutely Improves Insulin Resistance and Inflammatory Markers Independent From Body Composition

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