Association of serum IgA antibodies to milk antigens with severe atherosclerosis

Muscari, Antonio; Volta, Umberto; Bonazzi, Claudia; Puddu, Giovanni M.; Bozzoli, C; Gerratana, C.; Bianchi, F.B.; Puddu, Paolo

doi:10.1016/0021-9150(89)90088-9

Cited by 10 publications

(5 citation statements)

References 24 publications

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“…In subjects with severe diffuse atheroscle rosis we have found an increase in total serum IgA by both univariate and multivariate as sessment [7], Also IgA antibodies against milk proteins [8] and apo/lipoproteins [9] were often elevated in the same sera. Further more, in control subjects serum IgA levels progressively increase with age, and earlier in males than in females [10], thus paralleling the natural course of atherosclerotic diseases.…”

Section: Introductionmentioning

confidence: 81%

“…A tentative explanation for these different trends is that in some subjects a per sisting exposure to antigens selectively stimu lating the synthesis of IgA might occur (e.g. alimentary antigens [8], which might resem ble, to some extent, the antigens originally generated in the necrotic area). However, the IgA excess that is sometimes present long after a major ischemic event does seem to be constituted by specific antibodies against the original antigens, rather than antibodies gen erated by a nonspecific polyclonal activation.…”

Section: Discussionmentioning

confidence: 99%

“…The goal of the present study was to ascertain whether the association be tween total IgA and coronary atherosclerosis is of a causal type, not to assess the nature of the antigens against which such antibodies are directed. However, sera from atherosclerotic patients with high IgA levels tested by immunoenzymatic techniques may be positive for IgA antibodies against some milk proteins [8], several lipo-and apoproteins [9] and probably other proteins, involving multiple and per haps cross-specificities. The seemingly most logical specificity, i.e.…”

Section: Discussionmentioning

confidence: 99%

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Increased Serum IgA Levels in Subjects with Previous Myocardial Infarction or Other Major Ischemic Events

Muscari¹,

Bozzoli²,

Puddu³

et al. 1993

Cardiology

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To ascertain whether the increase in serum IgA, which has been found to be associated with the presence of severe atherosclerotic disease, precedes or follows the occurrence of major ischemic events (MIE), we studied the serum levels of IgA as well as IgG and IgM in 145 subjects with acute or previous ischemic events and 34 controls. The subjects with previous myocardial infarction had higher IgA levels with respect to the controls, the patients with angina pectoris and those with acute myocardial infarction, while no significant differences concerning IgG and IgM were found. In the subjects with previous extracoronary events, immunoglobulin levels tended to be even higher. Overall, 30% of the subjects with previous MIE and only 3% of the controls had IgA levels over 4.5 g/l (p = 0.0018). This study indicates that total serum IgA is a marker of previous major ischemic events (protracted immune response to denatured proteins?), rather than a factor predisposing to atherosclerosis development.

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Section: Introductionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Increased Serum IgA Levels in Subjects with Previous Myocardial Infarction or Other Major Ischemic Events

Muscari¹,

Bozzoli²,

Puddu³

et al. 1993

Cardiology

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show abstract

“…69 Clinical analysis showed that the concentration of IgM-MDA-LDL (malondialdehyde-modified low-density lipoprotein) was tightly associated with atherosclerotic events, 70 and high levels of IgM against MGO-apoB100 (methylglyoxal-modified apolipoprotein B100) were associated with reduced coronary artery calcification in patients with type 2 diabetes. 71 Similar to IgM, the level of plasma IgA was significantly associated with atherosclerosis, 72,73 and the presence of plasma IgA against phosphocholine was an important predictor of long-term atherosclerosis risk. 74…”

Section: The Role Of B Cells In Atherosclerosis and Calcificationmentioning

confidence: 97%

The roles of immune cells in atherosclerotic calcification

Cao

Liu

2021

Vascular

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Atherosclerosis is the leading cause of acute cardiovascular events, and vascular calcification is an important pathological phenomenon in atherosclerosis. Recently, many studies have shown that immune cells are closely associated with the development of atherosclerosis and calcification, but there are many conflicting viewpoints because of immune system complications, such as the pro-atherosclerotic and atheroprotective effects of regulatory B cells (Bregs), T helper type 2 (Th2) cells and T helper type 17 (Th17) cells. In this review, we summarize the studies on the roles of immune cells, especially lymphocytes and macrophages, in atherosclerotic calcification. Furthermore, we prepared graphs showing the relationship between T cells, B cells and macrophages and atherosclerotic calcification. Finally, we highlight some potential issues that are closely associated with the function of immune cells in atherosclerotic calcification. Based on current research results, this review summarizes the relationship between immune cells and atherosclerotic calcification, and it will be beneficial to understand the relationship of immune cells and atherosclerotic calcification.

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“…Its relevance is under study by Muscari et al 209 The presence of antibodies against dietary antigens is well documented.…”

Section: Breastfeeding and Onset Of Diabetesmentioning

confidence: 99%

Medical Complications of Mothers

Lawrence

2011

Breastfeeding

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Association of serum IgA antibodies to milk antigens with severe atherosclerosis

Cited by 10 publications

References 24 publications

Increased Serum IgA Levels in Subjects with Previous Myocardial Infarction or Other Major Ischemic Events

Increased Serum IgA Levels in Subjects with Previous Myocardial Infarction or Other Major Ischemic Events

The roles of immune cells in atherosclerotic calcification

Medical Complications of Mothers

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