Association of serum irisin and body composition with chronic kidney disease in obese Chinese adults: a cross-sectional study

Abstract

BackgroundIrisin, an exercise induced myokine, has broad implications for metabolism and energy homeostasis. Available evidence about the association of serum irisin with chronic kidney disease (CKD) is limited.MethodsCross-sectional data on socio-demographic, lifestyle, clinical characteristics and serum irisin were collected for 1,115 community-living obese Chinese adults (waist circumference ≥ 90 cm for men and ≥ 80 cm for women). CKD was defined as estimated glomerular filtration rate less than 60 ml/min per 1.73 m2 and/or the presence of albuminuria. Associations of serum irisin and body composition measurements with CKD were analyzed using multivariable logistic regression.ResultsThe overall prevalence of CKD were 23.1% (26.6% in females and 15.5% in males, p < 0.001). Subjects within quartile 4 group of serum irisin had significantly the lowest prevalence of CKD (22.9%, 22.2%, 28.7% and 18.7% for quartile 1–4 groups, respectively, p = 0.046). With adjustment for potential confounders, compared with those within quartile 1 group of serum irisin, subjects within quartile 4 group showed significantly decreased risk of CKD and marginally decreased risk of albuminuria, with the adjusted odds ratios (ORs, 95% CI) of 0.572 (0.353-0.927, p = 0.023) and 0.611 (0.373-1.000, p = 0.050), respectively. As for body composition measurements, only body fat percentage was significantly associated with both albuminuira and CKD, with ORs (95% CI) of 1.046 (1.002-1.092, p = 0.039) and 1.049 (1.006-1.093, p = 0.025), respectively. No statistically significant interaction effect between serum irisin and body composition measurements on CKD was found.ConclusionsOur results imply that high serum irisin level was associated with reduced risk of CKD, and should be confirmed in future studies. Furthermore, adiposity per se, rather than body weight or body shape, is independently associated with increased risk of CKD. Future studies should examine whether decreasing body fat percentage may prevent or slow CKD.

Serum uric acid is independently and linearly associated with risk of nonalcoholic fatty liver disease in obese Chinese adults

“…The present study was based on the baseline examination of the same cohort of 1,523 community-living healthy obese Chinese adults as our previous publications151625. Details on methods of subject sampling and recruitment have been described previously151625.…”

“…Details on methods of subject sampling and recruitment have been described previously151625. Briefly, a total of 1,523 subjects aged 40 years or older living in the Lianqian community, Xiamen, China with central obesity (waist circumference greater than 90 cm for men and 80 cm for women) were recruited from April 2011 to August 2011151625. Of them, 944 females and 421males with the complete information were left for analysis (Fig.…”

“…Details on clinical and biochemical measurements have been described previously1516. After removal of shoes and heavy clothing, each subject underwent weight, height and waist circumference measurements by using a calibrated scale.…”

“…In the present study of 1365 community-living healthy obese Chinese adults with the same baseline examination as that of our previous publications1516, we firstly aimed to examine the association of SUA with NAFLD, independent of insulin resistance and components of MetS. Secondly, we aimed to test if there is a non-linear relationship between SUA level and risk of NAFLD by using MFP modeling.…”

The effect of high protein diet and exercise on irisin, eNOS, and iNOS expressions in kidney

“…12,[26][27][28] Lower levels of irisin in type 2 diabetes mellitus, fatty liver and chronic kidney patients were remarkable. 9,[29][30][31] Studies were carried out about irisin levels on different tissues following an exercise (kidneys, liver, cardiac muscle, and skeletal muscle). Young rats had no difference in irisin levels after an exercise while older rats had increased irisin levels only in their kidney tissues.…”