Association of serum lactate and survival outcomes in patients undergoing therapeutic hypothermia after cardiac arrest

Assessment of muscle tissue oxygen saturation after out-of-hospital cardiac arrest

“…Because the use of therapeutic hypothermia increased, conflicting results appeared for numerous prognostic factors. Recently, it was shown that the first lactate measurement was not associated to outcome in cardiac arrest patients treated by therapeutic hypothermia [24]. In our study, lactate level on admission was higher in patients who eventually had a poor outcome.…”

Correlation between initial serum levels of lactate after return of spontaneous circulation and survival and neurological outcomes in patients who undergo therapeutic hypothermia after cardiac arrest

“…Therefore, in this study, we evaluated the use of serum levels of lactate and other clinical data collected within 1 h after ROSC for predicting survival and neurological outcomes at hospital discharge. Some previous studies investigated the use of early lactate values for predicting outcomes after cardiac arrest, but reported different results due to differences in study settings [20][21][22][23][24][25] . In addition, their limitations included having a small sample size and applying a specified initial ECG rhythm (ventricular fibrillation), and none of them included TH.…”

“…Thus, the composition of initial rhythm patterns in our population differed from prior reports. Donnino et al 23 and Starodub et al 22 reported that initial serum levels of lactate were not associated with survival outcomes in cardiac arrest patients. Donnino et al reported that in 79 OHCA patients, the initial levels were not associated with patient outcome, but effective lactate clearance was associated with improved outcome.…”

“…Early and effective clearance of serum lactate (i.e., lower levels) are associated with lower mortality in patients with many critical illnesses, including sepsis and severe trauma [13][14][15][16][17][18] . For cardiac arrest survivors, the relationships between clearance of serum lactate and neurological and survival outcomes have been studied [19][20][21][22][23] . However, few studies have addressed the potential relationship between initial serum levels of lactate and outcomes in patients who have been treated with TH.…”

Lack of improved outcomes with increased use of targeted temperature management following out-of-hospital cardiac arrest: A multicenter retrospective cohort study

“…10,11 Aside from the retrospective design, this study has several limitations that warrant discussion. First, in controlling for severity of illness and probability of our secondary outcomes we were unable to obtain specific point estimates of "down time" prior to [33][34][35][36] However, by limiting the study population to patients with an overall estimated time to ROSC under 30 min and dichotomizing patients by ROSC prior to hospital arrival we mitigated the potential for spectrum bias between epochs. Second, we lacked consistent access to hemodynamic and pharmacy data across the span of our study to allow us to adequately control for degrees of cardiovascular instability (i.e.…”