Association of serum levels of glycated albumin, C-reactive protein and tumor necrosis factor-α with the severity of coronary artery disease and renal impairment in patients with type 2 diabetes mellitus

Lü, Lin; Li, Pu; Xu, Xue Wei; Zhang, Qi; Zhang, Rui Yan; Zhang, Jian Sheng; Hu, Jian; Zheng, Yang; Lü, An Kang; Ding, Feng; Shen, Jie; Chen, Qiu Jin; Sheng, Lei; Fang, Dan; Shen, Wei Feng

doi:10.1016/j.clinbiochem.2007.03.022

Cited by 57 publications

(31 citation statements)

References 34 publications

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“…In our study, we found no significant differences in mean ±SD of HbA1c (9.131.8%) in complicated group in comparison with non complicated group (8.62.57% ) (p= 0.54).This result was in agreement to Lu et al (41) and Yoo et al (42) who found that serum HbA1c was not statistically significant between T2DM patients with and without CAD and among CAD subgroups this was due to CVD severity was not different between the two groups, suggesting that even asymptomatic patients with few risk factors could have severe CAD while Dale et al (37) who found that diabetics elderly patients complicated with CAD had elevated HbA1c and had four times higher risk of death from IHD compared with matched group without diabetes and diabetic patients with good diabetes control and this difference from our result may be due to age in non complicated group was higher than the age in the study of dale.…”

Section: Discussionsupporting

confidence: 83%

Study of Endogenous Sex Hormones and Inflammation in Elderly Women With Diabetes Mellitus

Draz¹,

Esmayel²,

Mousa³

et al. 2014

Zagazig University Medical Journal

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Background .C-Reactive Protein (CRP), an acute phase reactant has long been considered as a classic marker of inflammation. Ageing is characterized by a chronic, low-grade inflammatory status, the so-called "inflame-ageing". Diabetes is known to be also associated with low-grade inflammation .The normal process of reproductive ageing is characterized by marked hormonal changes, during menopause, estradiol (E2) level decreases dramatically, whereas testosterone level presents a small decline or remain unchanged. A large body of clinical data suggests the important roles of endogenous sex hormones in the pathogenesis of type 2 diabetes. In many studies in women, plasma estradiol and testosterone have been positively associated with glucose intolerance and insulin resistance, independently of adiposity. Objective .The aim of this study was to assess serum levels of endogenous sex hormones (estrogen and testosterone) as well as high sensitive CReactive protein ( hs-CRP) in elderly women with and without type 2 diabetes. Research Design. This study was done in the period between august 2009 to august 2011, The study population included a total number of 60 post menopausal elderly females, 20 healthy non diabetic elderly females as control group and 40 diabetic females. The diabetic females were further divided into two groups according to presence or absence of complications cardiovascular diseaes complicated group and non complicated group. They were also divided into two groups according to glycosylated hemoglobin level (HbA1c) to controlled group and non controlled group. Methods. Total testosterone, total estradiol, hs-CRP and HbA1c were measured in diabetic and non diabetic elderly women. Results. As regard hs-CRP there was a high significant difference between patients(2,2±,56 mg/L) and control group(1.60  0.39 mg/L) and also there was a significant difference between complicated(2.160.51 mg/L) and non complicated group(2.080.76 mg/L) and no significant difference among diabetics whether controlled or non controlled . As regard the serum estradiol, there was a high significant difference between patients (22.513.9 pg/ml) and control group (12.92.71 pg/ml). While there was no significant difference as regard presence or absence of complication and diabetes control. As regard the serum testosterone, there was no significant difference between patients and control group, presence or absence of complication and control of diabetes. Conclusion. In type 2 diabetic postmenopausal elderly women there was significant association between inflammation and serum estradiol while there was no association between inflammation and serum testosterone. As regarding presence or absence of cardiovascular complication and diabetes control neither of two hormones were associated with inflammation.

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Section: Discussionsupporting

confidence: 83%

Study of Endogenous Sex Hormones and Inflammation in Elderly Women With Diabetes Mellitus

Draz¹,

Esmayel²,

Mousa³

et al. 2014

Zagazig University Medical Journal

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“…Studies using self-monitoring of blood glucose and continuous glucose monitoring have found glycated albumin levels to better reflect glycaemic fluctuation [15,16]. Moreover glycated albumin levels were better correlated with severity of cardiovascular disease, and were also found to be a better indicator of glycaemic fluctuations than HbA 1c [17].…”

Section: Introductionmentioning

confidence: 97%

“…Compared with HbA 1c , glycated albumin is characterised by more rapid and greater changes, and can be used to confirm treatment effects when initiating or changing medications. Glycated albumin can also be used for patients with anaemia or haemoglobinopathies for whom measured HbA 1c levels may be inaccurate [10][11][12][13][14][15][16][17]. Recently, a user-friendly, highly accurate, automated enzymatic assay for measuring glycated albumin has been developed [14] and approved for clinical use in Japan.…”

Section: Introductionmentioning

confidence: 99%

Utility of glycated albumin for the diagnosis of diabetes mellitus in a Japanese population study: results from the Kyushu and Okinawa Population Study (KOPS)

et al. 2011

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Aims/hypothesis Glycated albumin is a measure of the mean plasma glucose concentration over approximately 2-3 weeks. We determined reference values for glycated albumin, and assessed its utility for the diagnosis of type 2 diabetes mellitus in the general population. Methods We studied 1,575 men and women (mean age, 49.9 years; range, 26-78 years) who participated in a periodic health examination in a suburban Japanese town. HbA 1c and fasting plasma concentrations of glucose (FPG) and glycated albumin were measured. Participants with FPG ≥7.0 mmol/l or HbA 1c ≥6.5% (48 mmol/mol) were diagnosed as having diabetes. In our laboratory, the glycated albumin assay had intra-assay and inter-assay CVs of 1.1% and 1.6%, respectively. Results Glycated albumin levels were significantly correlated with HbA 1c levels (r=0.766, p<0.001) and FPG (r= 0.706, p<0.001). The presence of diabetes was significantly higher in participants with glycated albumin levels between 15.0% and 15.9% (five of 276, 1.81%) than in those with glycated albumin <14% (three of 672, 0.45%) (p=0.037), and was markedly increased in those with a glycated albumin level >16% (58 of 207, 28.0%). Receiver operating characteristic curve analysis indicated that a glycated albumin level of ≥15.5% was optimal for predicting diabetes, with a sensitivity of 83.3% and a specificity of 83.3%. Conclusions/interpretation There is merit to further investigating the potential for glycated albumin to be used as an alternative measure of dysglycaemia for future research and clinical practice.

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“…Recently, it has been revealed that GA is an index that predicts the development of coronary artery disease (CAD) as well as its severity [30,31]. The relationship between GA and diabetic vascular complications will be further investigated.…”

Section: Postprandial Hyperglycemiamentioning

confidence: 99%

Clinical impact of glycated albumin as another glycemic control marker

2010

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Abstract. It is known that glycation among various proteins is increased in diabetic patients compared with non-diabetic subjects. Currently, among these glycated proteins, glycated hemoglobin (HbA 1C ) is used as the gold standard index of glycemic control in clinical practice for diabetes treatment. However, HbA 1C does not accurately reflect the actual status of glycemic control in some conditions where plasma glucose changes during short term, and in patients who have diseases such as anemia and variant hemoglobin. In comparison, another index of glycemic control, glycated albumin (GA), more accurately reflects changes in plasma glucose during short term and also postprandial plasma glucose. Although GA is not influenced by disorders of hemoglobin metabolism, it is affected by disorders of albumin metabolism. This review summarizes diseases and pathological conditions where GA measurement is useful. These include the status of glycemic control changes during short term, diseases which cause postprandial hyperglycemia, iron deficiency anemia, pregnancy, chronic liver disease (liver cirrhosis), chronic renal failure (diabetic nephropathy), and variant hemoglobin.

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Association of serum levels of glycated albumin, C-reactive protein and tumor necrosis factor-α with the severity of coronary artery disease and renal impairment in patients with type 2 diabetes mellitus

Cited by 57 publications

References 34 publications

Study of Endogenous Sex Hormones and Inflammation in Elderly Women With Diabetes Mellitus

Study of Endogenous Sex Hormones and Inflammation in Elderly Women With Diabetes Mellitus

Utility of glycated albumin for the diagnosis of diabetes mellitus in a Japanese population study: results from the Kyushu and Okinawa Population Study (KOPS)

Clinical impact of glycated albumin as another glycemic control marker

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