Association of serum lipid levels with psychotic symptoms in first-episode and drug naïve outpatients with major depressive disorder: a large-scale cross-sectional study

Wang, Xiaohong; Yang, Liying; Liu, Jiacheng; Kang, Chuanyi; Zheng, Yue; Qiu, Siyu; Zhao, Ying; Goodman, Colin; Wu, Hanjing Emily; Zhao, Na; Zhang, Xiangyang

doi:10.1016/j.jad.2021.10.053

Cited by 14 publications

(7 citation statements)

References 41 publications

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“…In addition to depressive symptoms and anxiety symptoms, we also found higher PANSS positive subscale score in MDD patients with comorbid lipid metabolism abnormalities. Similarly, psychotic symptoms were positively correlated with TC, LDL-C, and TG levels and negatively correlated with HDL-C, which is consistent with the findings of Wang et al ( 41 ). However, another cross-sectional study showed that MDD patients with comorbid severe anxiety or psychotic symptoms had higher TC, TG, and LDL-C levels and lower HDL-C levels compared to those without comorbidities ( 42 ).…”

Section: Discussionsupporting

confidence: 91%

Association of thyroid function with abnormal lipid metabolism in young patients with first-episode and drug naïve major depressive disorder

Ji²,

Lang³

et al. 2023

Front. Psychiatry

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IntroductionAbnormal lipid metabolism in patients with major depressive disorder (MDD) has received increasing attention. The coexistence of MDD and abnormal thyroid function has been intensively studied. Moreover, thyroid function is closely related to lipid metabolism. The aim of this study was to investigate the relationship between thyroid function and abnormal lipid metabolism in young patients with first-episode and drug naïve (FEDN) MDD.MethodsA total of 1,251 outpatients aged 18–44 years with FEDN MDD were enrolled. Demographic data were collected, and lipid and thyroid function levels were measured, including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free tetraiodothyronine (FT4), anti-thyroglobulin antibody (TG-Ab), and anti-thyroid peroxidase antibody (TPO-Ab). The Hamilton Rating Scale for Depression (HAMD), Hamilton Anxiety Rating Scale (HAMA), and Positive and Negative Syndrome Scale (PANSS) positive subscale were also assessed for each patient.ResultsCompared with young MDD patients without comorbid lipid metabolism abnormalities, patients with comorbid lipid metabolism abnormalities had higher body mass index (BMI) values, HAMD score, HAMA score, PANSS positive subscale score, TSH levels, TG-Ab levels, and TPO-Ab levels. Binary logistic regression analysis showed that TSH level, HAMD score and BMI were risk factors for abnormal lipid metabolism. TSH levels were an independent risk factor for abnormal lipid metabolism in young MDD patients. Stepwise multiple linear regression showed that both TC and LDL-C levels were positively correlated with TSH levels, HAMD and PANSS positive subscale scores, respectively. HDL-C levels were negatively correlated with TSH levels. TG levels were positively correlated with TSH and TG-Ab levels and HAMD score.DiscussionOur results show that thyroid function parameters, especially TSH levels, are implicated in abnormal lipid metabolism in young patients with FEDN MDD.

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Section: Discussionsupporting

confidence: 91%

Association of thyroid function with abnormal lipid metabolism in young patients with first-episode and drug naïve major depressive disorder

Ji²,

Lang³

et al. 2023

Front. Psychiatry

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“…While metabolic abnormalities are frequently observed in MDD patients, there is a dearth of research speci cally examining the metabolic markers of MDD patients with PS. An investigation conducted by Wang et al revealed that elevated TG levels were an independent risk factor for PS [22], which to our best knowledge was the lone analysis of PS risk factors in MDD patients from the FEDN. Furthermore, a longitudinal study demonstrated that patients with higher baseline TG levels experienced more severe PS symptoms and exhibited poorer social functioning during the 5-year follow-up period [32].…”

Section: Clinical Characteristics and Biochemical Parameters Of Patie...mentioning

confidence: 65%

“…In recent years, there have been numerous studies examining the relationship between MDD patients and biochemical markers, aiming to explore measurable indicators for MDD patients [16][17][18]. Additionally, there is substantial evidence indicating a connection between hormone levels [19][20][21]and metabolic markers [22,23] to PS in MDD patients. To illustrate, Contreras et al discovered that approximately 80% of depression samples exhibited at least one hormonal axis disturbance, with 40.0% and 5.0% experiencing two and three hormone axis disturbances, respectively [19].…”

Section: Introductionmentioning

confidence: 99%

“…Our recent investigation found that MDD patients with severe subclinical hyperthyroidism had more severe PS [21]. Furthermore, compared to MDD patients without PS, patients with PS displayed higher levels of serum total cholesterol (TC), triglycerides (TG), and low-density lipoprotein (LDL-C) as well as lower levels of high-density lipoprotein (HDL-C) [22].…”

Section: Introductionmentioning

confidence: 99%

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Predictors of psychotic symptoms in first-episode and drug-naïve major depressive disorder patients with a history of suicide attempts: A large cross-sectional study

Yang,

Wang,

Feng

et al. 2024

Preprint

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Background: Psychotic symptoms (PS) are common in patients with major depressive disorder (MDD); however, few studies have examined risk factors for PS in first-episode and drug-naïve (FEDN) MDD patients with a history of suicide attempts. The purpose of this study was to investigate the incidence and risk factors for PS in FEDN MDD patients with a history of suicide attempts, with the aim of providing implications for early intervention. Methods: A total of 1718 FEDN MDD patients were recruited through a cross-sectional study. The Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Positive and Negative Syndrome Scale (PANSS) were used to assess patients’ symptoms. In addition, demographic data and clinical indicators were collected. Results: We found that FEDN MDD patients with a history of suicide attempts were 5.06 times more likely to have PS than those without a history of suicide attempts. HAMD score, HAMA score, and thyroid-stimulating hormone (TSH) were significant predictors of PS in FEDN MDD patients with a history of suicide attempts. The combined area under the curve (AUC) value of 0.94 distinguished patients with PS from those without PS. Conclusions: This study shows a high prevalence of PS in FEDN MDD patients with a history of suicide attempts. Anxiety symptoms, depressive symptoms, and TSH levels appear to predict PS in FEDN MDD patients with a history of suicide attempts.

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“…There is also a close connection between lipid levels during pregnancy and BMI before pregnancy and pregnancy anxiety. LDL-C, TC, and TG levels are positively correlated with anxiety and depression [29]; however, HDL-C is negatively correlated with anxiety [30]. Additionally, TG is positively correlated with BMI before pregnancy [21], while TC, LDL-C, and HDL-C are negatively correlated with BMI before pregnancy [31].…”

Section: Research Status Of Serum Lipid Levels Bmi Before Pregnancy A...mentioning

confidence: 99%

Pre-pregnancy BMI and pregnancy anxiety in women with gestational diabetes mellitus: mediating effects of blood glucose and lipid levels1

Ouyang

Wu²

2022

Preprint

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Background: Body mass index (BMI) before pregnancy and blood glucose and lipid levels during and before pregnancy are associated with anxiety among pregnant women with gestational diabetes mellitus (GDM). No study has further explored the relationship between these factors. Our study is the first to explore the effects of blood glucose and lipids on the relationship between BMI and anxiety in pregnant women with GDM using mediation analysis.Methods: Pregnant women diagnosed with GDM after completing the oral glucose tolerance test during pregnancy were followed up from January 2019 to December 2021. Collecting basic information including age, education level, annual family income, pre-pregnancy BMI, gestational age, history of abortion, family history of anxiety and diabetes, sleep status, and other information. Results: After adjusting for relevant influencing factors, Pre-pregnancy BMI, FBG, HbA1c, 2hPG, and TG were still significantly correlated with the pregnancy anxiety scores . The results of the mediating effect model suggested that pre-pregnancy BMI significantly influenced the pregnancy anxiety scores in women with GDM (P<0.001); FBG, 2hPG, HbA1c, and TG significantly mediated the effect of BMI on the pregnancy anxiety scores, respectively, and played a partial mediator role between BMI and the pregnancy anxiety scores of pregnant women with GDM.Conclusion: Pre-pregnancy BMI was associated with pregnancy anxiety among pregnant women with GDM. High BMI before pregnancy can lead to increased anxiety . Blood glucose and lipid levels during pregnancy play a part in the influence of BMI before pregnancy on anxiety .

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Association of serum lipid levels with psychotic symptoms in first-episode and drug naïve outpatients with major depressive disorder: a large-scale cross-sectional study

Cited by 14 publications

References 41 publications

Association of thyroid function with abnormal lipid metabolism in young patients with first-episode and drug naïve major depressive disorder

Association of thyroid function with abnormal lipid metabolism in young patients with first-episode and drug naïve major depressive disorder

Predictors of psychotic symptoms in first-episode and drug-naïve major depressive disorder patients with a history of suicide attempts: A large cross-sectional study

Pre-pregnancy BMI and pregnancy anxiety in women with gestational diabetes mellitus: mediating effects of blood glucose and lipid levels1

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