Association of serum lipids with inflammatory bowel disease: a systematic review and meta-analysis

Abstract

BackgroundSerum lipid levels seem to be abnormal in Inflammatory bowel disease (IBD). However, the specific manifestation of abnormal serum lipid levels in IBD are heterogeneous among studies and have not been sufficiently determined yet.MethodsPubMed, EMBASE, and Cochrane Library databases were searched. Serum lipid levels were compared between IBD patients and Health individuals, Crohn’s (CD) and ulcerative colitis (UC), active and inactive, mild and non-mild patients, respectively. Meta-analyses were performed by using a random-effect model. Weight mean difference (WMD) with 95% confidence intervals (CIs) were calculated.ResultsOverall, 53 studies were included. Compared with healthy controls, IBD patients had significantly lower TC (WMD = −0.506, 95%CI = −0.674 to −0.338, p < 0.001), HDL-c (WMD = −0.122, 95%CI = −0.205 to −0.039, p = 0.004), and LDL-c (WMD = −0.371, 95%CI = −0.547 to −0.194, p < 0.001) levels. CD groups had a significantly lower TC (WMD = −0.349, 95%CI = −0.528 to −0.170, p < 0.0001) level as compared to UC groups. Active IBD and non-mild UC groups had significantly lower TC (WMD = −0.454, 95%CI = −0.722 to −0.187, p = 0.001) (WMD =0.462, 95%CI = 0.176 to 0.748, p = 0.002) and LDL-c (WMD = −0.225, 95%CI = −0.445 to −0.005, p = 0.045) (WMD =0.346, 95%CI = 0.084–0.609, p = 0.010) levels as compared to inactive IBD and mild UC groups, respectively.ConclusionThe overall level of serum lipids in IBD patients is lower than that of healthy individuals and is negatively associated with disease severity.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42022383885.

Cardiovascular implications of inflammatory bowel disease: An updated review

“…The overall level of serum lipids in IBD patients is negatively associated with disease severity[ 113 , 116 ]. On the contrary, disease activity has been reported to be an independent risk factor for development of CVD[ 117 - 119 ].…”

Explainable AI-prioritized plasma and fecal metabolites in inflammatory bowel disease and their dietary associations

“… 12 Unraveling such biological complexity necessitates targeted-omics studies, with metabolomics recently helping to identify distinct disease-related patterns 13 , 14 , 15 , 16 , 17 and key differences between individuals with IBD and those without. 18 , 19 , 20 These differences have been observed as alterations in fecal short-chain fatty acids 21 and serological lipids, such as cholesterol levels and its lipoprotein levels, 22 , 23 and as changes in amino acid profiles, generally increased in feces 21 , 24 and decreased in serum or plasma, 25 , 26 as well as energy-related metabolites. 27 , 28 …”