Association of Serum Magnesium with Gastrointestinal Bleeding in Peritoneal Dialysis Patients: a Multicentre Retrospective Study

Su, Ning; Tang, Xingming; Wang, Xiaoyang; Wen, Yan; Feng, Xiaoran; Zhou, Qian; Zhan, Xiaojiang; Shang, Sijia

doi:10.1007/s12011-022-03391-4

Cited by 2 publications

(1 citation statement)

References 40 publications

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“…Previous studies of patients on HD have shown the association of lower serum magnesium levels with higher mortality. 33,34 In PD patients, lower serum Mg also related to adverse health outcomes, for example, hospitalization, 35 gastrointestinal bleeding, 36 cardiovascular and all-cause mortality. 37 Therefore, it is proper to include Mg in…”

Section: Discussionmentioning

confidence: 99%

Development and validation of prediction model for technique failure in peritoneal dialysis patients: An observational study

Ling,

Wang,

Liu

et al. 2024

Nephrology

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AimThis study aimed to establish a prediction model in peritoneal dialysis patients to estimate the risk of technique failure and guide clinical practice.MethodsClinical and laboratory data of 424 adult peritoneal dialysis patients were retrospectively collected. The risk prediction models were built using univariate Cox regression, best subsets approach and LASSO Cox regression. Final nomogram was constructed based on the best model selected by the area under the curve.ResultsAfter comparing three models, the nomogram was built using the LASSO Cox regression model. This model included variables consisting of hypertension and peritonitis, serum creatinine, low‐density lipoprotein, fibrinogen and thrombin time, and low red blood cell count, serum albumin, triglyceride and prothrombin activity. The predictive model constructed performed well using receiver operating characteristic curve and area under the curve value, C‐index and calibration curve.ConclusionThis study developed and verified a new prediction instrument for the risk of technique failure among peritoneal dialysis patients.image

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Section: Discussionmentioning

confidence: 99%

Development and validation of prediction model for technique failure in peritoneal dialysis patients: An observational study

Ling,

Wang,

Liu

et al. 2024

Nephrology

View full text Add to dashboard Cite

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The relationship between serum uric acid and gastrointestinal bleeding in peritoneal dialysis patients: a propensity score analysis

Zhao,

Zheng,

Tian

et al. 2024

Renal Failure

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Purpose Gastrointestinal bleeding is an important gastrointestinal complication among peritoneal dialysis patients and correlated with a higher risk of mortality. Increased uric acid levels are a significant complication for peritoneal dialysis patients and have been associated with an increased risk of hemorrhagic stroke. The objective of the present study was to investigate the relationship between serum uric acid levels and gastrointestinal bleeding in peritoneal dialysis patients. Methods A total of 2498 peritoneal dialysis patients were recruited. Based on the optimal uric acid cutoff value, two groups of patients were divided. We constructed a propensity-score-matched population of 1762 patients by matching sex, age, and body mass index. Survival outcomes between the two groups were compared using adjusted Kaplan–Meier curves. We constructed the restricted cubic splines regression to assess the correlation between levels of uric acid and gastrointestinal bleeding. A multivariate Cox proportional hazards regression was performed to test whether higher levels of uric acid are an independent risk factor for gastrointestinal bleeding. We performed a forest plot to show interaction effects in different subgroups. Results According to restricted cubic splines regression, uric acid levels were positively correlated with the risk of gastrointestinal bleeding events. After adjusted different confounding factors, patients with high levels of uric acid were prone to experience gastrointestinal bleeding (HR 1.868, 95%CI 1.001–3.486). In subgroups, the interaction between higher levels of uric acid and utilizing proton pump inhibitors was significant (P for interaction = 0.034). Further research found that taking proton pump inhibitors could decrease the risk of gastrointestinal bleeding in peritoneal dialysis patients accompanied high levels of uric acid. Conclusion The baseline high levels of uric acid are an independent risk factor for gastrointestinal bleeding in patients undergoing peritoneal dialysis.

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Association of Serum Magnesium with Gastrointestinal Bleeding in Peritoneal Dialysis Patients: a Multicentre Retrospective Study

Cited by 2 publications

References 40 publications

Development and validation of prediction model for technique failure in peritoneal dialysis patients: An observational study

Development and validation of prediction model for technique failure in peritoneal dialysis patients: An observational study

The relationship between serum uric acid and gastrointestinal bleeding in peritoneal dialysis patients: a propensity score analysis

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