Association of serum mimecan with angiographic coronary collateralization in patients with stable coronary artery disease and chronic total occlusion

Shen, Ying; Ding, Feng; Zhang, Rui Yan; Zhang, Qi; Lü, Lin; Shen, Wei Feng

doi:10.1016/j.atherosclerosis.2016.07.916

Cited by 17 publications

(16 citation statements)

References 39 publications

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“… The data presented here support the research article “Association of serum mimecan with angiographic coronary collateralization in patients with stable coronary artery disease and chronic total occlusion” (Shen et al, 2016) [1] where elevated circulating mimecan levels reflected poor angiographic coronary collateralization in such patients. The data included in this article are composed by one figure and consist of (1) validation of serum mimecan measurement by assessing inter- and intra-assay variability in 45 samples; (2) findings on the relation of clinical and angiographic characteristics and biochemical parameters to coronary collateralization in 559 patients; (3) the diagnostic value of serum mimecan for poor collateralization, which was derived from plotting receiver-operating characteristic curves and logistic regression analysis.…”

supporting

confidence: 86%

“…The data consist of clinical characteristics and angiographic features along with biochemical measurements associated with coronary collateralization in patients with stable angina and chronic total occlusion, and the results of multivariable logistic regression analysis for diagnostic value of serum mimecan in detecting poor collateralization. The data also include the coefficient of variance for serum mimecan assay [1] .…”

Section: Datamentioning

confidence: 99%

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Data on the value of elevated circulating mimecan levels for detecting poor coronary collateralization in patients with stable angina and chronic total occlusion

Shen¹,

Ding²,

Zhang³

et al. 2016

Data in Brief

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The data presented here support the research article “Association of serum mimecan with angiographic coronary collateralization in patients with stable coronary artery disease and chronic total occlusion” (Shen et al., 2016) [1] where elevated circulating mimecan levels reflected poor angiographic coronary collateralization in such patients. The data included in this article are composed by one figure and consist of (1) validation of serum mimecan measurement by assessing inter- and intra-assay variability in 45 samples; (2) findings on the relation of clinical and angiographic characteristics and biochemical parameters to coronary collateralization in 559 patients; (3) the diagnostic value of serum mimecan for poor collateralization, which was derived from plotting receiver-operating characteristic curves and logistic regression analysis.

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supporting

confidence: 86%

Section: Datamentioning

confidence: 99%

Data on the value of elevated circulating mimecan levels for detecting poor coronary collateralization in patients with stable angina and chronic total occlusion

Shen¹,

Ding²,

Zhang³

et al. 2016

Data in Brief

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“…Besides severity of coronary obstruction [ 37 , 38 ], numerous factors that could possibly attenuate the development and biological function of coronary collaterals have been reported such as old age [ 39 ], traditional risk factors for coronary artery disease [ 40 – 44 ], hyperlipoprotein (a) [ 45 ], hyperuricemia [ 46 ] and elevated serum levels of CRP [ 47 ], TNF-a [ 48 ], N-terminal pro-brain natriuretic peptide [ 38 ] and mimecan [ 49 ], and high neutrophil/lymphocyte ratio [ 50 ]. In contrast, higher plasma levels of MCP-1 [ 51 ] or apelin [ 52 ] were associated with better coronary collateral development.…”

Section: Factors Influencing Coronary Collateralization In Diabetesmentioning

confidence: 99%

Reduced coronary collateralization in type 2 diabetic patients with chronic total occlusion

Shen

Ding

Dai

et al. 2018

Cardiovasc Diabetol

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BackgroundThe extent of coronary collateral formation is a primary determinant of the severity of myocardial damage and mortality after coronary artery occlusion. Type 2 diabetes mellitus (T2DM) represents an important risk factor for impaired collateral vessel growth. However, the mechanism of reduced coronary collateralization in type 2 diabetic patients remains unclear.MethodsWith the reference to the recent researches, this review article describes the pathogenic effects of T2DM on collateral development and outlines possible clinical and biochemical markers associated with reduced coronary collateralization in type 2 diabetic patients with chronic total occlusion (CTO).ResultsDiffuse coronary atherosclerosis in T2DM reduces pressure gradient between collateral donor artery and collateral recipient one, limiting collateral vessel growth and function. An interaction between advanced glycation end-products and their receptor activates several intracellular signaling pathways, enhances oxidative stress and aggravates inflammatory process. Diabetic condition decreases pro-angiogenic factors especially vascular endothelial growth factor and other collateral vessel growth related parameters. Numerous clinical and biochemical factors that could possibly attenuate the development of coronary collaterals have been reported. Increased serum levels of glycated albumin, cystatin C, and adipokine C1q tumor necrosis factor related protein 1 were associated with poor coronary collateralization in type 2 diabetic patients with stable coronary artery disease and CTO. Diastolic blood pressure and stenosis severity of the predominant collateral donor artery also play a role in coronary collateral formation.ConclusionsT2DM impairs collateral vessel growth through multiple mechanisms involving arteriogenesis and angiogenesis, and coronary collateral formation in patients with T2DM and CTO is influenced by various clinical, biochemical and angiographic factors. This information provides insights into the understanding of coronary pathophysiology and searching for potential new therapeutic targets in T2DM.

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“…Patients were categorized into poor (grade 0 or 1) or good (grade 2 or 3) coronary collateralization group. All angiograms were viewed by the two observers blinded to the other observers' findings, and the agreement of the assessment of coronary artery disease severity and collateral classification between the two observers was 98% and 97%, respectively 29 . Any difference in interpretation was resolved by a third reviewer.…”

Section: Coronary Collateral Scoringmentioning

confidence: 99%

Impact of coronary collateralization on long-term clinical outcomes in type 2 diabetic patients after successful recanalization of chronic total occlusion

Yang

Shen

Dai

et al. 2020

Preprint

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Background: To assess the prognostic role of coronary collaterals in patients with type 2 diabetes mellitus (T2DM) after successful percutaneous coronary intervention (PCI) for chronic total occlusion (CTO). Methods: Coronary collateralization was graded according to Rentrop scoring system in 198 type 2 diabetic patients and 335 non-diabetics with stable angina undergoing PCI for at least one CTO lesion. Left ventricular ejection fraction (LVEF) was determined and major adverse cardio-cerebral events (MACCE) were recorded during follow-up. Results: Poor collateralization was more common in patients with T2DM than in non-diabetics (40% vs 29%, p=0.008). At 13.5±4.1 months, the rate of composite MACCE (17.3% vs 27.6%, p=0.034) and repeat revascularization (15.2% vs 25.5%, p=0.026) was lower and the increase in LVEF (3.10 % vs 1.80%, p=0.024) was greater in patients with good collaterals than in those with poor collaterals for non-diabetic group, but did not differ for T2DM group (35% vs 44%; 30% vs 36%; 2.14% vs 1.65%, respectively, all p>0.05) except for a higher all-cause mortality in diabetic patients with poor collaterals (p=0.034). Multivariable Cox proportional hazards analysis showed that coronary collateralization was an independent factor for time to MACCE (HR 2.155，95%CI 1.290-3.599, P=0.003) and repeat revascularization (HR 2.326, 95%CI 1.357-3.986, p=0.002) in non-diabetic patients, but did not enter the model in those with T2DM. Conclusions: T2DM is associated with reduced coronary collateralization. Successful revascularization of CTO lesions results in a mild improvement in left ventricular function, but t he status of coronary collaterals has no independent effect on long-term clinical outcomes in patients with T2DM.

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Association of serum mimecan with angiographic coronary collateralization in patients with stable coronary artery disease and chronic total occlusion

Cited by 17 publications

References 39 publications

Data on the value of elevated circulating mimecan levels for detecting poor coronary collateralization in patients with stable angina and chronic total occlusion

Data on the value of elevated circulating mimecan levels for detecting poor coronary collateralization in patients with stable angina and chronic total occlusion

Reduced coronary collateralization in type 2 diabetic patients with chronic total occlusion

Impact of coronary collateralization on long-term clinical outcomes in type 2 diabetic patients after successful recanalization of chronic total occlusion

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