Association of serum omentin-1 levels with coronary artery disease

Zhong, Xia; Zhang, Hai Yang; Tan, Hui; Zhou, Yi; Liu, Fu Li; Chen, Fu Qin; Shang, De Ya

doi:10.1038/aps.2011.26

Cited by 123 publications

(98 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Omentin-1 may be involved in vascular disease due to its effect on endothelial function, vasodilatation, arterial compliance and calcification, and inflammation. 11,12,21,22 We did not find any correlation between omentin-1 and carotid IMT (mean) . In subgroup analysis, omentin-1 levels were lower in patients with carotid plaque than without carotid plaque.…”

Section: Discussioncontrasting

confidence: 56%

“…Furthermore, the levels of omentin-1 are decreased in patients with atherosclerotic vascular disease. 14,[20][21][22]30 Taking into consideration the above associations, the effect of insulin sensitizing drugs and weight loss on omentin-1 have been studied and increases in omentin-1 levels are found after metformin treatment and weight loss. 31,32 The other important factor regulating omentin-1 is inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…[13][14][15][16][17][18][19] Recent reports have usually demonstrated an inverse association between omentin-1 and atherosclerosis (AS). 18,[20][21][22][23] Little is known about omentin-1 in CKD. It may be implicated in the pathogenesis of CVD in these patients.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Serum omentin-1, inflammation and carotid atherosclerosis in patients with non-diabetic chronic kidney disease

Şengül¹,

Duygulu²,

Dindar³

et al. 2013

Renal Failure

View full text Add to dashboard Cite

Background and aim: Omentin-1 is suggested to affect inversely atherosclerosis (AS). Data about omentin-1 is limited to chronic kidney disease (CKD). Our aim was to examine omentin-1 in non-diabetic CKD patients who are not dialyzed and investigate its relationships with inflammation and carotid AS. Materials and Methods: We performed a cross-sectional study in 55 non-diabetic CKD patients and 30 healthy controls. Baseline clinical and laboratory data were obtained for all participants. Serum omentin-1 and interleukin-6 (IL-6) levels were measured according to the manufacturer's instructions. Carotic plaque and intima-media thickness (IMT) were assessed by carotid ultrasonography. The homeostasis model assessment of insulin resistance index (HOMA-IR) was used to assess IR. Results: Omentin-1 and IL-6 levels in the patient group were found to be higher than the control group; the differences were statistically significant (p ¼ 0.01 and p ¼ 0.04, respectively). Carotid IMT(mean) was significantly higher in the patient group (p ¼ 0.01). Omentin-1 did not correlate with IL-6 and IMT in the patient group (p ¼ 0.51 and p ¼ 0.76, respectively). In subgroup analysis, omentin-1 levels in patients with carotid plaque were lower than those without carotid plaque (179.5 AE 88.1 ng/ml and 185.9 AE 67.8 ng/ml, respectively). However, the difference was not statistically significant (p ¼ 0.47). Conclusion: We conclude that omentin-1 is higher in not dialyzed non-diabetic CKD and there is no correlation between omentin-1 and IL-6 or carotid IMT(mean).

show abstract

Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Serum omentin-1, inflammation and carotid atherosclerosis in patients with non-diabetic chronic kidney disease

Şengül¹,

Duygulu²,

Dindar³

et al. 2013

Renal Failure

View full text Add to dashboard Cite

show abstract

“…Serum omentin-1 concentrations were reported to correlate passively with BMI and waist circumference [5] . Decreased serum level of omentin-1 was reported in polycystic ovary syndrome [6] , diabetes [7] and coronary artery disease [8] . Moreover, omentin was reported to prevent apoptosis of cardiomyoblasts via inhibition of mitochondrial ROS production [9] .…”

Section: Introductionmentioning

confidence: 99%

Omentin-1 in serum and seminal plasma correlate with semen quality

et al. 2017

View full text Add to dashboard Cite

Introduction: Adipokines are differently regulated in the male reproductive tract and they were reported to affect sperm functionality. Serum omentin-1 was reported to have a range of effects on various cell types. Aim: To explore the presence of omentin-1in human semen, to investigate its relation with semen parameters in both fertile and infertile men and to compare its serum and seminal plasma levels in particular conditions such as; smoking, varicocele and leukocytospermia. Methods: Thirty nine infertile and 26 fertile men were enrolled in this case control study. They were subjected to history taking, clinical/physical examination, semen analysis, and measurement of omentin-1 in serum and seminal plasma, DNA fragmentation index (DFI) and seminal reactive oxygen species (ROS). Results: Omentin-1 was detected in all analyzed semen and serum samples (n=65). The concentration of omentin-1 was significantly higher in seminal plasma than in serum. Serum and seminal omentin-1 were positively correlated with sperm concentration and percentage of progressive motility and were negatively correlated with percentage of abnormal forms, DFI and ROS. The mean seminal plasma level of omentin-1 was significantly decreased in smokers and in patients with leukocytospermia. The mean serum level of omentin-1 was significantly decreased in patients with varicocele. Both serum and seminal omentin-1 levels were significantly lower in infertile patients than fertile men. Conclusions: Semen and serum Omentin-1 correlate with semen quality. In cases of leukocytospermia and smoking, seminal omentin-1 concentrations were decreased, suggesting that it may play a regulatory role in inflammation of the male reproductive system.

show abstract

“…Omentin increases the sensitivity of adipocytes to insulin, and increasing obesity and insulin resistance have been correlated with lower levels of omentin (18,19). Furthermore, individuals with coronary artery disease and rheumatoid arthritis have reduced omentin levels (20,21). In addition, omentin suppresses the ERK/NF-κB pathway to promote vasodilation in blood vessels of rats and diminishes the expression of adhesion molecules triggered by TNF-α in endothelial cells (22,23).…”

Section: Introductionmentioning

confidence: 99%

The levels of visceral adipose tissue-derived serpin, omentin-1 and tumor necrosis factor-α in the gingival crevicular fluid of obese patients following periodontal therapy

et al. 2016

View full text Add to dashboard Cite

The aim of this clinical study was to determine levels of visceral adipose tissue-derived serpin (vaspin), omentin-1, and tumor necrosis factor-alpha (TNF-α) in the gingival crevicular fluid (GCF) of obese and non-obese periodontitis patients following nonsurgical periodontal therapy. Seventy-six subjects were separated into four groups according to periodontal and anthropometric measurements: a periodontal-healthy group, a chronic periodontitis (CP) group, a periodontal-healthy with obesity group, and a CP with obesity group. Nonsurgical periodontal treatment was administered to periodontitis patients. Before treatment and at 6 weeks after treatment, GCF samples were analyzed and clinical periodontal parameters were examined. Enzyme-linked immunosorbent assays were used to measure the levels of vaspin, omentin-1, and TNF-α. Obese and non-obese CP patients displayed higher levels of vaspin and TNF-α (P < 0.008), which declined following treatment (P < 0.025), and lower omentin levels (P < 0.008), which increased after treatment (P < 0.025). There was a negative correlation between the total amount of vaspin and omentin-1 in all groups. Obese and non-obese patients had opposing levels of vaspin and omentin-1 in the GCF; therefore, these may represent diagnostic and prognostic indicators of periodontal disease and therapeutic outcome. (J Oral Sci 58, [465][466][467][468][469][470][471][472][473] 2016)

show abstract

Association of serum omentin-1 levels with coronary artery disease

Cited by 123 publications

References 34 publications

Serum omentin-1, inflammation and carotid atherosclerosis in patients with non-diabetic chronic kidney disease

Serum omentin-1, inflammation and carotid atherosclerosis in patients with non-diabetic chronic kidney disease

Omentin-1 in serum and seminal plasma correlate with semen quality

The levels of visceral adipose tissue-derived serpin, omentin-1 and tumor necrosis factor-α in the gingival crevicular fluid of obese patients following periodontal therapy

Contact Info

Product

Resources

About