Association of serum osteocalcin levels with major adverse cardiovascular events: A 4.4‐year retrospective cohort study

Zhang, Xueli; Shen, Yun; Xu, Yiting; Xiong, Qian; Lu, Zhigang; Ma, Xiaojing; Bao, Yuqian; Jia, Weiping

doi:10.1111/1440-1681.12853

Cited by 12 publications

(10 citation statements)

References 33 publications

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“…According to many authors, the increase in serum concentration of osteocalcin reflects the metabolic activity of osteoblasts of bone tissue, and also indicates its role in the regulation of the process of resorption, because under high levels of osteocalcin, bone resorption processes are also enhanced [22]. Therefore, it is both a general indicator of the level of bone metabolism and a possible prognostic indicator of the progression of osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

The interrelationship of bone and cardiovascular remodeling biomarkers and clinical peculiarities of coronary artery disease in postmenopausal women

et al. 2020

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Objectives: To investigate the interrelationship between bone and cardiovascular remodeling biomarkers and some clinical, laboratory and instrumental parameters of coronary artery disease in postmenopausal women. Material and methods: The double open cross-sectional monocentric clinical study in parallel groups involved 115 women in the postmenopausal period with coronary artery disease (CAD): stable exertional angina of functional class (FC) II-III (mean age 67.07 ±0.92 years). Depending on the bone mineral density (BMD) state, all patients were divided into 3 groups: group 1 (n = 24)-patients with normal BMD (T-criterion more than 1 SD); group 2 (n = 34)-patients with osteopenia (T-criterion from-1 SD to-2.5 SD); group 3 (n = 44)-patients with osteoporosis (T-criterion less than-2.5 SD). The selected control group consisted of 12 relatively healthy women of the corresponding age. All patients underwent cardiovascular and bone remodeling biomarkers' assessment, lipid profile tests, daily monitoring of ECG by Holter, two-dimensional echocardiography and pulsed-wave Doppler. Intima-media complex (IMC) measurement, ultrasound densitometry, and the FRAX algorithm were performed. Results: In women with coronary artery disease and postmenopausal osteoporosis (PMO), there was a significant increase in the level of bone osteoprotegerin (OPG), osteocalcin and vascular remodeling biomarkers (VEGF-A, homocysteine) in parallel with the progression of BMD disorders. The existence of a correlative dependence between osteoprotegerin level and the 10-year risk of fracture of the radial bone (r = 0.46; p < 0.05) was discovered. A probable interrelationship between the OPG, osteocalcin, VEGF-A and homocysteine level and decrease of the T-criterion was observed. An interrelationship between the bone and cardiovascular remodeling biomarkers and atherogenic dyslipidemia, diastolic dysfunction of the left ventricle, dilatation of the left atrium, thickening of the intima-media complex, arrhythmic complications and vegetative imbalance development was proved (p < 0.05), which confirms their clinical and pathogenic role in patients with CAD and PMO. Conclusions: The results obtained prove the existing interrelationship of bone and cardiovascular remodeling biomarkers with the state of bone mineral density and clinical peculiarities of coronary artery disease in postmenopausal women.

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Section: Discussionmentioning

confidence: 99%

The interrelationship of bone and cardiovascular remodeling biomarkers and clinical peculiarities of coronary artery disease in postmenopausal women

et al. 2020

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“…It has been reported that dysregulations of BMP pathway may make an impact on vascular dysfunctions, while overactive BMP signaling in FOP may play a central role in the development of hypoxia-induced pulmonary hypertension [18]. Recent studies have demonstrated serum OC level is closely associated with [19] found that lower serum OC levels were associated with a higher risk of major adverse cardiovascular events in a retrospective cohort study of Chinese subjects. A longitudinal analysis demonstrated that men with low OC levels exhibit increased allcause mortality and cardiovascular disease related mortality [20].…”

Section: Discussionmentioning

confidence: 99%

Serum osteocalcin level is associated with the mortality in Chinese patients with Fibrodysplasia ossificans progressiva aged ≤18 years at diagnosis

She

Ran

Fang

et al. 2020

BMC Musculoskelet Disord

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Background: Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder characterized by extraskeletal heterotopic ossification. It is well recognized that FOP can lead to a devastating condition of disability. However, the mortality rate of FOP patients in China and risk factors for mortality are still largely unclear. Methods: We conducted a retrospective research on a cohort of 65 cases of FOP patients in China from 2008 to 2018. We reviewed medical records of these FOP patients to retrieve information such as date of birth/death, gender, clinical features, genotypes and biochemical parameters and analyze the correlation of these parameters with the mortality. Results: 92.3% (60/65 cases) patients were classic FOP patients, 3.1% (2/65 cases) were FOP-plus and 4.6% (3/65 cases) were FOP variants. 9 cases of this cohort were dead during the ten-year period, and the overall mortality rate was 13.8%. c.617G > A mutation was confirmed in all non-survivors. In FOP patients≤18 years at diagnosis, nonsurvivors demonstrated significantly lower blood osteocalcin and alkaline phosphatase levels compared with survivors (P < 0.05), and spearman correlation and logistic regression analysis indicated that serum osteocalcin and alkaline phosphatase levels were negatively correlated with the mortality. Furthermore, the receiver-operating characteristic curve analysis showed serum osteocalcin had the largest area under the curve of 0.855 among four biochemical parameters, and serum osteocalcin < 65.9 ng/ml displayed a good capacity to discriminate the nonsurvivors from survivors in FOP patients aged 18 years and younger at diagnosis. Conclusions: Our findings showed that the mortality rate of FOP was 13.8% in China. Serum OC level was negatively correlated with the mortality in Chinese FOP patients ≤18 years at diagnosis.

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“…According to many authors, the increase of osteocalcin serum concentration can be considered as a possible prognostic indicator of disturbance of bone architecture 20,21 . Also, many studies have revealed its involvement in the processes of vascular calcification, which occur with the progression of atherosclerotic process 21,22 .…”

Section: Discussionmentioning

confidence: 99%

The diagnostic and prognostic value of biomarkers in women with coronary artery disease and osteoporosis

Mykhailovska¹,

Stetsiuk²,

Kulynych³

et al. 2020

Arch Balk Med Union

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Valeur diagnostique et pronostique des biomarqueurs chez les femmes atteintes de maladie coronarienne et d'ostéoporose Introduction. Depuis le début de la ménopause chez la population féminine, l'incidence des pathologies cardiovasculaires et les modifications de la densité minérale osseuse (DMO) ont considérablement augmenté Le but de l'étude. Étudier la valeur diagnostique et pronostique des biomarqueurs du remodelage osseux et vasculaire en déterminant leur relation avec les facteurs de progression de la maladie coronarienne en combinaison avec l'ostéoporose post-ménopause (PMOS). Matériels et méthodes. L'étude comprenait 115 femmes ménopausées chez lesquelles on avait diagnostiqué une maladie coronarienne. En fonction de l'état de la DMO, les patientes sont divisées en trois groupes: (1) avec une DMO normale, (2) avec une ostéopénie, (3) avec une ostéoporose. Le groupe de contrôle était ABSTRACT Introduction. Since the onset of menopause, the incidence of cardiovascular pathology and changes in bone mineral density (BMD) in the female population significantly increase. The objective of the study. To determine the diagnostic and prognostic value of bone and cardiovascular remodeling biomarkers in terms of determining their interrelationship with coronary artery disease (CAD) progression on the background of postmenopausal osteoporosis (PMOS). Material and methods. The study involved 115 women in the postmenopausal period, with a diagnosis of CAD. Depending on the BMD state, patients were divided into three groups: (1)-with normal BMD, (2)with osteopenia, (3)-with osteoporosis. The selected control group consisted of 12 relatively healthy women of the corresponding age. Daily monitoring of electrocardiogram by Holter, two-dimensional echocardiography, intima-media thickness (IMT) measurement, the

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Association of serum osteocalcin levels with major adverse cardiovascular events: A 4.4‐year retrospective cohort study

Cited by 12 publications

References 33 publications

The interrelationship of bone and cardiovascular remodeling biomarkers and clinical peculiarities of coronary artery disease in postmenopausal women

The interrelationship of bone and cardiovascular remodeling biomarkers and clinical peculiarities of coronary artery disease in postmenopausal women

Serum osteocalcin level is associated with the mortality in Chinese patients with Fibrodysplasia ossificans progressiva aged ≤18 years at diagnosis

The diagnostic and prognostic value of biomarkers in women with coronary artery disease and osteoporosis

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