Association of serum periostin levels with clinical features in children with asthma

Abstract

Background The aim of this study was to investigate the association of serum periostin levels with clinical features in children with asthma. Methods Children with physician‐diagnosed asthma who attended regularly to an outpatient pediatric allergy and asthma center were enrolled in the study along with control subjects. Asthma severity and control status of the patients were evaluated according to the recent GINA guidelines. Results A total of 158 children (125 with asthma and 33 age‐ and sex‐matched control subjects) with a median age of 10.2 years (range 5.9‐17.0) were enrolled. Asthma severity was mild in 41 (32.8%), moderate in 63 (50.4%), and severe in 21 (16.8%) children. Children with asthma had significantly higher periostin levels than controls (53.1 ± 13.1 vs 43.0 ± 11.2 ng/mL, P < .001). The mean serum periostin levels in children with severe asthma (63.8 ± 10.8) were significantly higher than in children with moderate asthma (53.3 ± 12.7) and mild asthma (47.4 ± 11.1) (P < .001). Results of multivariable logistic regression analysis demonstrated an association between serum periostin levels and asthma severity in children (OR, 1.10; 95% CI, 1.04‐1.15, P < .001). When analyzed for the best cut‐off value with the highest combined sensitivity and specificity, a cut‐off value of 52 ng/mL for serum periostin level was obtained with sensitivity, specificity, PPV, and NPV of 100%, 50%, 29%, and 100%, respectively. Conclusion Although serum periostin levels are higher in children with asthma, its diagnostic role in identifying children with severe asthma is limited.

Serum Periostin Level in Children with Asthma

“…Relatively higher values have been reported in the studies which have not used ELISA [12,15]. Periostin levels in the present study population were comparable to those reported in Egypt, Finland, and Turkey [18,19,21]. The study conducted by Nejman-Gryz et al in Poland enrolled children in the age group closest to the present study [20].…”

“…Evidence exists regrading a positive correlation of serum periostin levels with increasing asthma severity [18,19]. Similar relationship with asthma control status has not been seen [19,22].…”

“…Evidence exists regrading a positive correlation of serum periostin levels with increasing asthma severity [18,19]. Similar relationship with asthma control status has not been seen [19,22]. On the other hand, Habernau Mena et al showed mean periostin levels to be lower among children with severe asthma in a group of patients with uncontrolled asthma [23].…”

“…Effects of age, gender, and growth have also not been explored adequately [12][13][14][15]. In a number of studies, children with asthma have been found to have higher serum periostin levels compared to healthy controls [16][17][18][19]. However, uncertainty persists regarding correlation between serum periostin and eosinophilic markers in children [20][21][22][23].…”

Pathological Roles and Clinical Usefulness of Periostin in Type 2 Inflammation and Pulmonary Fibrosis

“…severity BM Significantly higher in children with severe asthma than with mild to moderate asthma [107].…”