Association of serum periostin with aspirin-exacerbated respiratory disease

Kim, Mi Ae; Izuhara, Kenji; Ohta, Shoichiro; Ono, Junya; Yoon, Moon Kyung; Ban, Ga Young; Yoo, Hye-Soo; Shin, Yoo Seob; Ye, Young-Min; Nahm, Dong-Ho; Park, Hae‐Sim

doi:10.1016/j.anai.2014.06.014

Cited by 76 publications

(82 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, according to earlier results, these two lung function parameters are expected to increase in healthy pregnant women compared to the non-pregnant state; hence in our pregnant asthmatic patients these lung function results have to be regarded as actually worse than they would seem to be in non-pregnant conditions [7] and thus the association between periostin and worse lung function may be more obvious in this group. Optimal lung function and well- In our study we could not confirm the previous data [20,39] as we did not detect higher peripheral periostin levels in bronchial asthma (without pregnancy) than in healthy controls. Of note, normal circulating levels of periostin or cut-off values in asthma are not defined yet and different values were considered as elevated in the different studies [20,21,22,24,39].…”

Section: Discussioncontrasting

confidence: 56%

“…Optimal lung function and well- In our study we could not confirm the previous data [20,39] as we did not detect higher peripheral periostin levels in bronchial asthma (without pregnancy) than in healthy controls. Of note, normal circulating levels of periostin or cut-off values in asthma are not defined yet and different values were considered as elevated in the different studies [20,21,22,24,39]. In the study by Jia et al [21] the median serum level was as low as 24.5 (19.6-30.6) ng/mL in severe uncontrolled, treated asthmatic patients, while the average asthmatic serum level was 92.8 (± 38.4) ng/mL found by Kanemitsu et al [20] and 76.5 (± 35.2) ng/mL found by Kim et al [39], both examining more heterogeneous, smoking and co-morbid populations.…”

Section: Discussioncontrasting

confidence: 56%

“…In the study by Jia et al [21] the median serum level was as low as 24.5 (19.6-30.6) ng/mL in severe uncontrolled, treated asthmatic patients, while the average asthmatic serum level was 92.8 (± 38.4) ng/mL found by Kanemitsu et al [20] and 76.5 (± 35.2) ng/mL found by Kim et al [39], both examining more heterogeneous, smoking and co-morbid populations. In Kim's study [39] a cut-off value of 54.5 ng/mL discriminated asthmatic patients from healthy controls, with 71.8% sensitivity and 63.2% specificity (AUC = 0.75, p < 0.001). Our results are in line with these with a median value of 45.25 (32.67-64.55) ng/mL in the ANP group and 54.02 (44.30-74.94) in the AP group.…”

Section: Discussionmentioning

confidence: 94%

“…The previously reported correlation between periostin concentration and peripheral eosinophil percentage [20,39] was detected as a trend in Similarly to an earlier study [11] we measured peripheral CRP and IL-6 levels also, in order to have a more complete view on the inflammatory status of the patients. We observed slightly but clinically not relevantly elevated CRP levels in both asthmatic groups.…”

Section: Discussionmentioning

confidence: 99%

“…Of note, normal circulating levels of periostin or cut-off values in asthma are not defined yet and different values were considered as elevated in the different studies [20,21,22,24,39]. In the study by Jia et al [21] the median serum level was as low as 24.5 (19.6-30.6) ng/mL in severe uncontrolled, treated asthmatic patients, while the average asthmatic serum level was 92.8 (± 38.4) ng/mL found by Kanemitsu et al [20] and 76.5 (± 35.2) ng/mL found by Kim et al [39], both examining more heterogeneous, smoking and co-morbid populations. In Kim's study [39] a cut-off value of 54.5 ng/mL discriminated asthmatic patients from healthy controls, with 71.8% sensitivity and 63.2% specificity (AUC = 0.75, p < 0.001).…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Circulating periostin level in asthmatic pregnancy

et al. 2016

View full text Add to dashboard Cite

Objective: Asthma often complicates pregnancy and represents a risk for complications.Periostin is considered as a biomarker of asthma; however, as it also plays a role in normal gestation, pregnancy may influence circulating periostin levels. This is the first study assessing periostin in asthmatic pregnancy.Methods: Plasma periostin levels were investigated in asthma (asthmatic non-pregnant, ANP; N = 19) and asthmatic pregnancy (AP; N = 14), compared to healthy non-pregnant controls (HNP; N = 12) and healthy pregnant women (HP; N = 17). The relationship between periostin levels and asthma control determinants was also evaluated. The diagnostic efficacy of periostin to detect uncontrolled asthma was analyzed using ROC analysis. (54.02 [44.30-74.94] ng/mL, p = 0.0346 vs. ANP). Periostin levels of the two pregnant groups were similar (p > 0.05). In AP women periostin correlated negatively with FEV 1 (r = -0.5516) and positively with Raw (r = 0.5535; both p < 0.05).Conclusions: Pregnancy itself increases circulating periostin levels and this elevation is detectable in asthmatic pregnancy as well. Although periostin correlates with lung function in asthmatic pregnancy, periostin as a biomarker has to be handled with caution in pregnant patients due to the influence of pregnancy on its plasma level.

show abstract

Section: Discussioncontrasting

confidence: 56%

Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Circulating periostin level in asthmatic pregnancy

et al. 2016

View full text Add to dashboard Cite

show abstract

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

558

888

View full text Add to dashboard Cite

Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

show abstract

Periostin as a biomarker in chronic rhinosinusitis: A contemporary systematic review

Danielides

Lygeros

Kanakis

et al. 2022

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

Background The role of periostin, a matricellular protein encoded by the POSTN gene, in chronic rhinosinusitis with nasal polyposis (CRSwNP) is reviewed. Periostin is considered a potential biomarker of endotype and may be useful for evaluating response to treatment. Methods Search terms in PubMed and Web of Science (1990–March 2022) included: ((periostin) OR (POSTN)) AND ((sinusitis) OR (nasal polyp) OR (CRSwNP) OR (CRS). The primary outcomes were differences in tissue, serum, and nasal lavage between CRSwNP and CRS without NP (CRSsNP) or controls. Associated factors reported to affect periostin expression, data regarding participants’ clinical characteristics, disease endotypes, laboratory methods, and samples’ origin were also pooled. Studies on <10 patients were excluded. Results Out of 101 records harvested through database searching, 29 prospective cross‐sectional or case‐control studies were eligible for review and qualitative analysis. Tissue sample origin, concurrent infection, current and past medication, primary or recurrent disease, allergic rhinitis, and smoking status should be considered as confounding factors for periostin levels. Periostin and POSTN messenger RNA (mRNA) levels were consistently and significantly higher in CRSwNP than CRSsNP and controls. Despite the distinctly different inflammation patterns among CRSwNP endotypes, periostin‐related remodeling patterns seemed to be similar. Conclusion Tissue and serum periostin levels, and POSTN expression appear elevated in CRSwNP, especially in eosinophilic inflammation, compared to CRSsNP and controls. Disease severity and comorbidities are also reflected in periostin and POSTN values. Carefully designed prospective studies may establish the role of periostin as a biomarker in CRSwNP and allow its incorporation in clinical practice.

show abstract

Association of serum periostin with aspirin-exacerbated respiratory disease

Cited by 76 publications

References 37 publications

Circulating periostin level in asthmatic pregnancy

Circulating periostin level in asthmatic pregnancy

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Periostin as a biomarker in chronic rhinosinusitis: A contemporary systematic review

Contact Info

Product

Resources

About